Dr. François Gros-Louis is a regular researcher at the CHU Research Center of Québec-Laval University and Professor in the Department of Surgery of the School of Medicine at Laval University. Dr. Gros-Louis’ research activities are grouped together at the Multidisciplinary Center for Tissue Engineering (LOEX), a research center dedicated to organogenesis, stem cells, regenerative medicine and to the reconstruction of living human tissues and organs through tissue engineering. He holds the Canada Research Chair in Biomodeling and Treatment of Brain Diseases, and is the co-director of the induced pluripotent stem cell platform (iPSC).

Several neurological conditions such as neurodegenerative diseases and other brain diseases occupy a prominent place because of their severity and increasing frequency related to the aging of the population. One of the major obstacles to understanding the development of these diseases is the accessibility of neuronal tissues. Dr. Gros-Louis’ research, at the crossroads between basic research and clinical research, is positioned in a fast-growing research field that aims to reconstruct human tissue through tissue engineering, using patient-derived tissue, to model and better understand the pathophysiological mechanisms underlying these diseases. The main objective of his research program is to reconstruct by tissue engineering, from the patient’s own cells, organs / organoids (skins and blood vessels) whose histological, physiological and functional properties make it possible to reproduce the pathological signatures of various brain diseases (Amyotrophic Lateral Sclerosis (ALS), intracranial aneurysm and neurofibromatosis). The specific objectives are: 1) to identify new strategies for early diagnosis, 2) to study and monitor the progression of targeted diseases, 3) to evaluate the response to existing and future treatments, 4) to identify and understand pathogenic mechanisms, and 5) to identify specific biomarkers and to develop new therapeutic pathways. Dr. Gros-Louis has played a major role in the discovery and application of a novel method for the in vitro reconstruction of tissue, through tissue engineering, for the study of ALS, neurofibromatosis, and intracranial aneurysms.

1401, 18e Rue
LOEX / CMDGT
R-211
Québec, Québec
Canada G1J 1Z4
49 entries « 4 of 5 »

Daoud H, Valdmanis PN, Gros-Louis F, Belzil V, Spiegelman D, Henrion E, Diallo O, Desjarlais A, Gauthier J, Camu W, Dion PA, Rouleau GA

Resequencing of 29 candidate genes in familial and sporadic ALS patients

Journal Article

Arch Neurol, 68 (5), 2011.

Gros-Louis F, Soucy G, Lariviere R, Julien JP

Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS

Journal Article

J Neurochem, 113 (5), 2010.

Abstract | Links:

Bosco DA, Morfini G, Karabacak NM, Song Y, Gros-Louis F, Pasinelli P, Goolsby H, Fontaine BA, Lemay N, McKenna-Yasek D, Frosch MP, Agar JN, Julien JP, Brady ST, Brown Jr

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

Journal Article

Nat Neurosci, 13 (11), 2010.

Abstract | Links:

Gros-Louis F, Andersen PM, Dupre N, Urushitani M, Dion P, Souchon F, D'Amour M, Camu W, Meininger V, Bouchard JP, Rouleau GA, Julien JP

Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis

Journal Article

Proc Natl Acad Sci U S A, 106 (51), 2009.

Abstract | Links:

Gros-Louis F, Kriz J, Kabashi E, McDearmid J, Millecamps S, Urushitani M, Lin L, Dion P, Zhu Q, Drapeau P, Julien JP, Rouleau GA

Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish

Journal Article

Hum Mol Genet, 17 (17), 2008.

Abstract | Links:

Dupre N, Gros-Louis F, Chrestian N, Verreault S, Brunet D, de Verteuil D, Brais B, Bouchard JP, Rouleau GA

Clinical and genetic study of autosomal recessive cerebellar ataxia type 1

Journal Article

Ann Neurol, 62 (1), 2007.

Abstract | Links:

Dupre N, Bouchard JP, Gros-Louis F, Rouleau GA

[Mutations in SYNE-1 lead to a newly discovered form of autosomal recessive cerebellar ataxia]

Journal Article

Med Sci (Paris), 23 (3), 2007.

| Links:

Gros-Louis F, Dupre N, Dion P, Fox MA, Laurent S, Verreault S, Sanes JR, Bouchard JP, Rouleau GA

Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia

Journal Article

Nat Genet, 39 (1), 2007.

Abstract | Links:

Thiffault I, Rioux MF, Tetreault M, Jarry J, Loiselle L, Poirier J, Gros-Louis F, Mathieu J, Vanasse M, Rouleau GA, Bouchard JP, Lesage J, Brais B

A new autosomal recessive spastic ataxia associated with frequent white matter changes maps to 2q33-34

Journal Article

Brain, 129 (Pt 9), 2006.

Abstract | Links:

Gros-Louis F, Gaspar C, Rouleau GA

Genetics of familial and sporadic amyotrophic lateral sclerosis

Journal Article

Biochim Biophys Acta, 1762 (11-12), 2006.

Abstract | Links:

49 entries « 4 of 5 »
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Active projects

  • Chaire de recherche du Canada en génie tissulaire et modélisation 3D des maladies du cerveau, from 2023-05-01 to 2030-04-30
  • Depicting disease heterogeneity in neurofibromatosis type 1 and the role of dermal fibroblasts in the establishment of microenvironment favouring NF1-associated skin tumor formation using personalized tissue-engineered 3D models, from 2023-10-01 to 2028-09-30
  • Depicting disease heterogeneity in neurofibromatosis type 1 and the role of microenvironment in NF1-associated skin tumor formation through personalized tissue-engineered 3D models, from 2023-03-01 to 2024-02-29
  • Génie tissulaire et modélisation 3D des maladies du cerveau, from 2023-04-01 to 2024-03-31
  • Organogenèse de muqueuse nasale autologue pour la reconstruction endoscopique endonasale en chirurgie de la base du crâne, from 2023-10-01 to 2028-09-30

Recently finished projects

  • Chaire de recherche du Canada en biomodélisation et traitement des maladies du cerveau, from 2017-11-01 to 2022-10-31
  • Chaire de recherche sur les organes reconstruits en laboratoire et leurs applications cliniques, from 2013-05-01 to 2023-12-01
  • Conversion directe de fibroblastes en cellules de Schwann pour stimuler la réparation des nerfs périphériques, from 2022-04-01 to 2023-03-31
  • Creating an Open Science Repository of ARCA1 iPSCs, from 2021-05-31 to 2023-05-31
  • Design and testing of a next-generation tissue-engineered living human heart valve, from 2020-03-31 to 2023-03-31
  • Les cellules souches pluripotentes génétiquement corrigées comme thérapie pour l’epidermolyse bulleuse simplex, from 2022-04-01 to 2023-03-31
  • Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, from 2017-04-01 to 2022-03-31
  • Renforcement de la plateforme de production de cellules souches induites à la pluripotence (IPSC) du CRCHU de Québec, from 2019-12-05 to 2023-03-31
Data provided by the Université Laval research projects registery