Dr. François Gros-Louis is a regular researcher at the CHU Research Center of Québec-Laval University and Professor in the Department of Surgery of the School of Medicine at Laval University. Dr. Gros-Louis’ research activities are grouped together at the Multidisciplinary Center for Tissue Engineering (LOEX), a research center dedicated to organogenesis, stem cells, regenerative medicine and to the reconstruction of living human tissues and organs through tissue engineering. He holds the Canada Research Chair in Biomodeling and Treatment of Brain Diseases, and is the co-director of the induced pluripotent stem cell platform (iPSC).
Several neurological conditions such as neurodegenerative diseases and other brain diseases occupy a prominent place because of their severity and increasing frequency related to the aging of the population. One of the major obstacles to understanding the development of these diseases is the accessibility of neuronal tissues. Dr. Gros-Louis’ research, at the crossroads between basic research and clinical research, is positioned in a fast-growing research field that aims to reconstruct human tissue through tissue engineering, using patient-derived tissue, to model and better understand the pathophysiological mechanisms underlying these diseases. The main objective of his research program is to reconstruct by tissue engineering, from the patient’s own cells, organs / organoids (skins and blood vessels) whose histological, physiological and functional properties make it possible to reproduce the pathological signatures of various brain diseases (Amyotrophic Lateral Sclerosis (ALS), intracranial aneurysm and neurofibromatosis). The specific objectives are: 1) to identify new strategies for early diagnosis, 2) to study and monitor the progression of targeted diseases, 3) to evaluate the response to existing and future treatments, 4) to identify and understand pathogenic mechanisms, and 5) to identify specific biomarkers and to develop new therapeutic pathways. Dr. Gros-Louis has played a major role in the discovery and application of a novel method for the in vitro reconstruction of tissue, through tissue engineering, for the study of ALS, neurofibromatosis, and intracranial aneurysms.
LOEX / CMDGT
R-211
Québec, Québec
Canada G1J 1Z4
Latest news
- [ULaval Nouvelles] COVID-19: des effets persistants sur le goût et l’odorat chez le tiers des personnes infectées 2022-05-30
- [Radio-Canada] COVID-19 et perte d’odorat sous la loupe des chercheurs du CHU de Québec 2020-09-01
- Six sportifs s’associent à la recherche sur les commotions cérébrales 2019-02-08
Persisting chemosensory impairments in 366 healthcare workers following COVID-19: an 11-month follow-up
Journal ArticleChem Senses, 47 , 2022.
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Generation of two induced pluripotent stem cell lines (UQACi002-A and UQACi005-A) from two patients with KRT14 epidermolysis bullosa simplex mutations
Journal ArticleStem Cell Res, 61 , 2022.
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Tissue-engineered in vitro modeling of the impact of Schwann cells in amyotrophic lateral sclerosis
Journal ArticleBiotechnol Bioeng, 119 (7), 2022.
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Generation of three induced pluripotent stem cell lines (UQACi003-A, UQACi004-A, and UQACi006-A) from three patients with KRT5 epidermolysis bullosa simplex mutations
Journal ArticleStem Cell Res, 60 , 2022.
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Moyamoya Disease Susceptibility Gene RNF213 Regulates Endothelial Barrier Function
Journal ArticleStroke, 53 (4), 2022.
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The Biobanque québécoise de la COVID-19 (BQC19)-A cohort to prospectively study the clinical and biological determinants of COVID-19 clinical trajectories
Journal ArticlePLoS One, 16 (5), 2021.
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Chemosensory Dysfunctions Induced by COVID-19 Can Persist up to 7 Months: A Study of Over 700 Healthcare Workers
Journal ArticleChem Senses, 46 , 2021.
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Biofabrication of a three dimensional human-based personalized neurofibroma model
Journal ArticleBiotechnol J, 16 (6), 2021.
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Characterization of the phenotype with cognitive impairment and protein mislocalization in SCA34
Journal ArticleNeurol Genet, 6 (2), 2020.
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Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors
Journal ArticleBiomed Res Int, 2020 , 2020.
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Active projects
- Chaire de recherche du Canada en biomodélisation et traitement des maladies du cerveau, from 2017-11-01 to 2022-10-31
- Chaire de recherche sur les organes reconstruits en laboratoire et leurs applications cliniques, from 2013-05-01 to 2023-08-12
- Creating an Open Science Repository of ARCA1 iPSCs, from 2021-05-31 to 2023-05-31
- Design and testing of a next-generation tissue-engineered living human heart valve, from 2020-03-31 to 2023-03-31
- Renforcement de la plateforme de production de cellules souches induites à la pluripotence (IPSC) du CRCHU de Québec, from 2019-12-05 to 2023-03-31
Recently finished projects
- Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, from 2017-04-01 to 2022-03-31
- Redifférenciation de cellules IPSC en oligodendrocytes et établissement d'un modèle tridimensionnel de leucodystrophie associée à POLR3A, from 2019-12-17 to 2020-12-16