Dr. François Gros-Louis is a regular researcher at the CHU Research Center of Québec-Laval University and Professor in the Department of Surgery of the School of Medicine at Laval University. Dr. Gros-Louis’ research activities are grouped together at the Multidisciplinary Center for Tissue Engineering (LOEX), a research center dedicated to organogenesis, stem cells, regenerative medicine and to the reconstruction of living human tissues and organs through tissue engineering. He holds the Canada Research Chair in Biomodeling and Treatment of Brain Diseases, and is the co-director of the induced pluripotent stem cell platform (iPSC).

Several neurological conditions such as neurodegenerative diseases and other brain diseases occupy a prominent place because of their severity and increasing frequency related to the aging of the population. One of the major obstacles to understanding the development of these diseases is the accessibility of neuronal tissues. Dr. Gros-Louis’ research, at the crossroads between basic research and clinical research, is positioned in a fast-growing research field that aims to reconstruct human tissue through tissue engineering, using patient-derived tissue, to model and better understand the pathophysiological mechanisms underlying these diseases. The main objective of his research program is to reconstruct by tissue engineering, from the patient’s own cells, organs / organoids (skins and blood vessels) whose histological, physiological and functional properties make it possible to reproduce the pathological signatures of various brain diseases (Amyotrophic Lateral Sclerosis (ALS), intracranial aneurysm and neurofibromatosis). The specific objectives are: 1) to identify new strategies for early diagnosis, 2) to study and monitor the progression of targeted diseases, 3) to evaluate the response to existing and future treatments, 4) to identify and understand pathogenic mechanisms, and 5) to identify specific biomarkers and to develop new therapeutic pathways. Dr. Gros-Louis has played a major role in the discovery and application of a novel method for the in vitro reconstruction of tissue, through tissue engineering, for the study of ALS, neurofibromatosis, and intracranial aneurysms.

1401, 18e Rue
LOEX / CMDGT
R-211
Québec, Québec
Canada G1J 1Z4
+1 418-525-4444, extension 61708
francois.gros-louis@crchu... francois.gros-louis@fmed....

Latest news

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Ndongo Sonfack DJ, Tanguay Boivin C, Touzel Deschênes L, Maurand T, Maguemoun C, Berthod F, Gros-Louis F, Champagne PO

Bioengineering Human Upper Respiratory Mucosa: A Systematic Review of the State of the Art of Cell Culture Techniques

Journal Article

Bioengineering (Basel), 11 (8), 2024.

Abstract | Links:

Brodeur A, Roy V, Touzel-Deschênes L, Bianco S, Droit A, Fradette J, Ruel J, Gros-Louis F

Transcriptomic Analysis of Mineralized Adipose-Derived Stem Cell Tissues for Calcific Valve Disease Modelling

Journal Article

Int J Mol Sci, 25 (4), 2024.

Abstract | Links:

Hadji A, Louit A, Roy V, Blais M, Berthod F, Gros-Louis F, Dupré N

Autosomal and X-Linked Degenerative Ataxias: From Genetics to Promising Therapeutics

Book Chapter

Trials for Cerebellar Ataxias: From Cellular Models to Human Therapies, pp. 141-181, 2023, ISBN: 9783031243455.

Abstract | Links:

Brodeur A, Winter A, Roy V, Touzel Deschênes L, Gros-Louis F, Ruel J

Spherical rotary cell seeding system for production of small-caliber tissue-engineered blood vessels with complex geometry

Journal Article

Sci Rep, 13 (1), 2023.

Abstract | Links:

Louit A, Beaudet MJ, Blais M, Gros-Louis F, Dupré N, Berthod F

In Vitro Characterization of Motor Neurons and Purkinje Cells Differentiated from Induced Pluripotent Stem Cells Generated from Patients with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay

Journal Article

Stem Cells Int, 2023 , 2023.

Abstract | Links:

Roy V, Paquet A, Touzel-Deschênes L, Khuong HT, Dupré N, Gros-Louis F

Heterozygous NF1 dermal fibroblasts modulate exosomal content to promote angiogenesis in a tissue-engineered skin model of neurofibromatosis type-1

Journal Article

J Neurochem, 167 (4), 2023.

Abstract | Links:

Nmezi B, Bey GR, Oranburg TD, Dudnyk K, Lardo SM, Herdman N, Jacko A, Rubio S, Alcocer EL, Kofler J, Kim D, Rankin J, Kivuva E, Gutowski N, Schon K, van den Ameele J, Chinnery PF, Sousa SB, Palavra F, Toro C, Pinto E Vairo F, Saute J, Pan L, Alturkustani M, Hammond R, Gros-Louis F, Gold M, Park Y, Bernard G, Raininko R, Zhou J, Hainer SJ, Padiath QS

An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants

Journal Article

bioRxiv, 2023.

Abstract | Links:

Roy V, Bienjonetti I, Brodeur A, Dion-Albert L, Touzel-Deschênes L, Gould PV, Saikali S, Laforce RJ, Gros-Louis F

LMNB1-duplication mediated nuclear architecture alteration and demyelination of cerebral white matter in a patient with ADLD

Journal Article

Neuropathol Appl Neurobiol, 2023.

| Links:

Bchetnia M, Martineau L, Racine V, Powell J, McCuaig C, Morin C, Dupérée A, Gros-Louis F, Laprise C

Generation of three induced pluripotent stem cell lines (UQACi003-A, UQACi004-A, and UQACi006-A) from three patients with KRT5 epidermolysis bullosa simplex mutations

Journal Article

Stem Cell Res, 60 , 2022.

Abstract | Links:

Bchetnia M, Martineau L, Racine V, Powell J, McCuaig C, Morin C, Dupérée A, Gros-Louis F, Laprise C

Generation of two induced pluripotent stem cell lines (UQACi002-A and UQACi005-A) from two patients with KRT14 epidermolysis bullosa simplex mutations

Journal Article

Stem Cell Res, 61 , 2022.

Abstract | Links:

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Active projects

  • Chaire de recherche du Canada en génie tissulaire et modélisation 3D des maladies du cerveau, from 2023-05-01 to 2030-04-30
  • Depicting disease heterogeneity in neurofibromatosis type 1 and the role of dermal fibroblasts in the establishment of microenvironment favouring NF1-associated skin tumor formation using personalized tissue-engineered 3D models, from 2023-10-01 to 2028-09-30
  • Organogenèse de muqueuse nasale autologue pour la reconstruction endoscopique endonasale en chirurgie de la base du crâne, from 2023-10-01 to 2028-09-30

Recently finished projects

  • Chaire de recherche du Canada en biomodélisation et traitement des maladies du cerveau, from 2017-11-01 to 2022-10-31
  • Chaire de recherche sur les organes reconstruits en laboratoire et leurs applications cliniques, from 2013-05-01 to 2023-12-01
  • Conversion directe de fibroblastes en cellules de Schwann pour stimuler la réparation des nerfs périphériques, from 2022-04-01 to 2023-03-31
  • Creating an Open Science Repository of ARCA1 iPSCs, from 2021-05-31 to 2023-05-31
  • Depicting disease heterogeneity in neurofibromatosis type 1 and the role of microenvironment in NF1-associated skin tumor formation through personalized tissue-engineered 3D models, from 2023-03-01 to 2024-02-29
  • Design and testing of a next-generation tissue-engineered living human heart valve, from 2020-03-31 to 2023-03-31
  • Génie tissulaire et modélisation 3D des maladies du cerveau, from 2023-04-01 to 2024-03-31
  • Les cellules souches pluripotentes génétiquement corrigées comme thérapie pour l’epidermolyse bulleuse simplex, from 2022-04-01 to 2023-03-31
  • Renforcement de la plateforme de production de cellules souches induites à la pluripotence (IPSC) du CRCHU de Québec, from 2019-12-05 to 2023-03-31
Data provided by the Université Laval research projects registery