Dr. François Gros-Louis is a regular researcher at the CHU Research Center of Québec-Laval University and Professor in the Department of Surgery of the School of Medicine at Laval University. Dr. Gros-Louis’ research activities are grouped together at the Multidisciplinary Center for Tissue Engineering (LOEX), a research center dedicated to organogenesis, stem cells, regenerative medicine and to the reconstruction of living human tissues and organs through tissue engineering. He holds the Canada Research Chair in Biomodeling and Treatment of Brain Diseases, and is the co-director of the induced pluripotent stem cell platform (iPSC).
Several neurological conditions such as neurodegenerative diseases and other brain diseases occupy a prominent place because of their severity and increasing frequency related to the aging of the population. One of the major obstacles to understanding the development of these diseases is the accessibility of neuronal tissues. Dr. Gros-Louis’ research, at the crossroads between basic research and clinical research, is positioned in a fast-growing research field that aims to reconstruct human tissue through tissue engineering, using patient-derived tissue, to model and better understand the pathophysiological mechanisms underlying these diseases. The main objective of his research program is to reconstruct by tissue engineering, from the patient’s own cells, organs / organoids (skins and blood vessels) whose histological, physiological and functional properties make it possible to reproduce the pathological signatures of various brain diseases (Amyotrophic Lateral Sclerosis (ALS), intracranial aneurysm and neurofibromatosis). The specific objectives are: 1) to identify new strategies for early diagnosis, 2) to study and monitor the progression of targeted diseases, 3) to evaluate the response to existing and future treatments, 4) to identify and understand pathogenic mechanisms, and 5) to identify specific biomarkers and to develop new therapeutic pathways. Dr. Gros-Louis has played a major role in the discovery and application of a novel method for the in vitro reconstruction of tissue, through tissue engineering, for the study of ALS, neurofibromatosis, and intracranial aneurysms.
LOEX / CMDGT
R-211
Québec, Québec
Canada G1J 1Z4
Latest news
- IRSC : Un financement de près de 16 millions de dollars pour 34 projets de recherche 2023-03-07
- [Le Chuchoteur] Recherche clinique en neurochirurgie : quand le génie entre au bloc opératoire 2022-09-26
- [ULaval Nouvelles] COVID-19: des effets persistants sur le goût et l’odorat chez le tiers des personnes infectées 2022-05-30
- Bellenfant, SabrinaEmployeeHôpital de l'Enfant-Jésus+1 418-990-8255, extension 61679Sabrina.Bellenfant@crchudequebec.ulaval.ca
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Québec, Québec
Canada G1J 1Z4 - Bienjonetti, IsabellaDoctoral studentHôpital de l'Enfant-Jésusisabella.bienjonetti.1@ulaval.caisabella.bienjonetti@crchudequebec.ulaval.ca
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Québec, QC
Canada G1J 1Z4 - Brodeur, AlyssaMaster studentHôpital de l'Enfant-Jésus+1 418-525-4444, extension 61704alyssa.brodeur.1@ulaval.caalyssa.brodeur@crchudequebec.ulaval.ca
1401 18e Rue
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Québec, QC
Canada G1J 1Z4 - Brodeur, AlyssaDoctoral studentHôpital de l'Enfant-Jésus+1 418-525-4444, extension 61704alyssa.brodeur.1@ulaval.caalyssa.brodeur@crchudequebec.ulaval.ca
1401 18e Rue
R-203
Québec, QC
Canada G1J 1Z4 - Brodeur, AlyssaEmployeeHôpital de l'Enfant-Jésus+1 418-525-4444, extension 61704alyssa.brodeur.1@ulaval.caalyssa.brodeur@crchudequebec.ulaval.ca
1401 18e Rue
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Québec, QC
Canada G1J 1Z4 - Clément, VincentMaster student+1 418-525-4444, extension 84563vincent.clement.2@ulaval.cavincent.clement@crchudequebec.ulaval.ca
- Clément, VincentDoctoral student+1 418-525-4444, extension 84563vincent.clement.2@ulaval.cavincent.clement@crchudequebec.ulaval.ca
- Martineau, LaurieEmployeeHôpital de l'Enfant-Jésus+1 418-525-4444, extension 61707Laurie.Martineau@crchudequebec.ulaval.ca
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R-209
Québec, Québec
Canada G1J 1Z4 - Paquet, AlexandreMaster studentalexandre.paquet@crchudequebec.ulaval.ca
- Roy, VincentEmployeeHôpital de l'Enfant-Jésus+1 418-525-4444, extension 61717vincent.roy.15@ulaval.cavincent.roy@crchudequebec.ulaval.ca
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R-114
Québec, QC
Canada G1J 1Z4 - Touzel-Deschênes, LydiaEmployeeHôpital de l'Enfant-Jésus+1 418-990-8252, extension 61679+1 418-990-8248Lydia.T-Deschenes@crchudequebec.ulaval.ca
1401, 18e Rue
R-118
Québec, Québec
Canada G1J 1Z4
An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants
Journal ArticlebioRxiv, 2023.
In Vitro Characterization of Motor Neurons and Purkinje Cells Differentiated from Induced Pluripotent Stem Cells Generated from Patients with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay
Journal ArticleStem Cells Int, 2023 , 2023.
Spherical rotary cell seeding system for production of small-caliber tissue-engineered blood vessels with complex geometry
Journal ArticleSci Rep, 13 (1), 2023.
RNF213 Loss-of-Function Promotes Angiogenesis of Cerebral Microvascular Endothelial Cells in a Cellular State Dependent Manner
Journal ArticleCells, 12 (1), 2022.
Tridimensional cell culture of dermal fibroblasts promotes exosome-mediated secretion of extracellular matrix proteins
Journal ArticleSci Rep, 12 (1), 2022.
Impact of Exosomes Released by Different Corneal Cell Types on the Wound Healing Properties of Human Corneal Epithelial Cells
Journal ArticleInt J Mol Sci, 23 (20), 2022.
Persisting chemosensory impairments in 366 healthcare workers following COVID-19: an 11-month follow-up
Journal ArticleChem Senses, 47 , 2022.
Generation of two induced pluripotent stem cell lines (UQACi002-A and UQACi005-A) from two patients with KRT14 epidermolysis bullosa simplex mutations
Journal ArticleStem Cell Res, 61 , 2022.
Tissue-engineered in vitro modeling of the impact of Schwann cells in amyotrophic lateral sclerosis
Journal ArticleBiotechnol Bioeng, 119 (7), 2022.
Generation of three induced pluripotent stem cell lines (UQACi003-A, UQACi004-A, and UQACi006-A) from three patients with KRT5 epidermolysis bullosa simplex mutations
Journal ArticleStem Cell Res, 60 , 2022.
Active projects
- Chaire de recherche du Canada en génie tissulaire et modélisation 3D des maladies du cerveau, from 2023-05-01 to 2030-04-30
- Chaire de recherche sur les organes reconstruits en laboratoire et leurs applications cliniques, from 2013-05-01 to 2023-12-01
- Depicting disease heterogeneity in neurofibromatosis type 1 and the role of microenvironment in NF1-associated skin tumor formation through personalized tissue-engineered 3D models, from 2023-03-01 to 2024-02-29
- Génie tissulaire et modélisation 3D des maladies du cerveau, from 2023-04-01 to 2024-03-31
Recently finished projects
- Chaire de recherche du Canada en biomodélisation et traitement des maladies du cerveau, from 2017-11-01 to 2022-10-31
- Conversion directe de fibroblastes en cellules de Schwann pour stimuler la réparation des nerfs périphériques, from 2022-04-01 to 2023-03-31
- Creating an Open Science Repository of ARCA1 iPSCs, from 2021-05-31 to 2023-05-31
- Design and testing of a next-generation tissue-engineered living human heart valve, from 2020-03-31 to 2023-03-31
- Les cellules souches pluripotentes génétiquement corrigées comme thérapie pour l’epidermolyse bulleuse simplex, from 2022-04-01 to 2023-03-31
- Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, from 2017-04-01 to 2022-03-31
- Renforcement de la plateforme de production de cellules souches induites à la pluripotence (IPSC) du CRCHU de Québec, from 2019-12-05 to 2023-03-31