Dr. Fawzi Aoudjit is a senior scientist at the CHU de Québec Research Centre and a professor at the department of microbiology-infectiology and immunology of the Laval University School of Medicine. His research program seeks to understand the mechanisms controlling T cell activity in tissues during inflammatory/autoimmune diseases and cancer, with a focus on the role of the adhesion molecules that bind to extracellular matrix, the integrins. T cells play an important role in the adaptive immune response, but are also critical to the development of inflammatory diseases, and could become malignant and lead to cancer. Recent work by Dr. Aoudjit’s group significantly contributed to understand the importance of extracellular matrix-binding integrins in the regulation of T cell activation and the development of immune response. Along these lines, Dr. Aoudjit and his team have shown that the collagen-binding integrin alpha2beta1 is an important pathway in Th17 cell activation and in the development of arthritis. These studies were highlighted in the news bulletin ‘Immune regulation news’. Dr. Aoudjit received several acknowledgements for his work among which, the New Investigator Award from the Canadian Institutes of Health Research, in 2004.

The current objectives aim to

  1. understand how collagen receptors such as integrins and discoïdin domain receptors interact to promote the survival and migration of T cell subsets in inflammatory tissues; two critical T cell functions necessary to the development of inflammation, as well as to mounting an anti-cancer immune response.
  2. determine the role of integrins in the development of lymphoblastic leukemia by investigating their implication in the tissue dissemination of leukemic T cells, and in their resistance to chemotherapy; two cancer features that limit the efficacy of anti-cancer treatments.

The implication of these receptors in the development of inflammatory diseases and cancer is being investigated in human T cell models, in preclinical models of autoimmune diseases, leukemia, and in models of anti-cancer immunity, as well as at the clinical level with the collaboration of clinicians.

In addition to advancing knowledge, these studies aim at the discovery of novel therapeutic targets and treatments for autoimmune diseases and cancer.

CHUL
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2
58 entries « 6 of 6 »

Aoudjit F, Potworowski EF, St-Pierre Y

Bi-directional induction of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 during T lymphoma/endothelial cell contact: implication of ICAM-1

Journal Article

J Immunol, 160 (6), 1998.

Abstract | Links:

Aoudjit F, Potworowski EF, Springer TA, St-Pierre Y

Protection from lymphoma cell metastasis in ICAM-1 mutant mice: a posthoming event

Journal Article

J Immunol, 161 (5), 1998.

Abstract | Links:

Aoudjit F, Potworowski EF, St-Pierre Y

The metastatic characteristics of murine lymphoma cell lines in vivo are manifested after target organ invasion

Journal Article

Blood, 91 (2), 1998.

Abstract | Links:

Aoudjit F, Estève PO, Desrosiers M, Potworowski EF, St-Pierre Y

Gelatinase B (MMP-9) production and expression by stromal cells in the normal and adult thymus and experimental thymic lymphoma

Journal Article

Int J Cancer, 71 (1), 1997.

Abstract | Links:

Aoudjit F, Brochu N, Bélanger B, Stratowa C, Hiscott J, Audette M

Regulation of intercellular adhesion molecule-1 gene by tumor necrosis factor-alpha is mediated by the nuclear factor-kappaB heterodimers p65/p65 and p65/c-Rel in the absence of p50

Journal Article

Cell Growth Differ, 8 (3), 1997.

Abstract | Links:

Mehindate K, Al-Daccak R, Aoudjit F, Damdoumi F, Fortier M, Borgeat P, Mourad W

Interleukin-4, transforming growth factor beta 1, and dexamethasone inhibit superantigen-induced prostaglandin E2-dependent collagenase gene expression through their action on cyclooxygenase-2 and cytosolic phospholipase A2

Journal Article

Lab Invest, 75 (4), 1996.

Abstract | Links:

Aoudjit F, Brochu N, Morin N, Poulin G, Stratowa C, Audette M

Heterodimeric retinoic acid receptor-beta and retinoid X receptor-alpha complexes stimulate expression of the intercellular adhesion molecule-1 gene

Journal Article

Cell Growth Differ, 6 (5), 1995.

Abstract | Links:

Aoudjit F, Bossé M, Stratowa C, Voraberger G, Audette M

Regulation of intercellular adhesion molecule-1 expression by retinoic acid: analysis of the 5' regulatory region of the gene

Journal Article

Int J Cancer, 58 (4), 1994.

Abstract | Links:

58 entries « 6 of 6 »
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Active projects

  • Expression and function of discoidin domain receptor 1 in T cells, from 2017-04-01 to 2023-03-31
  • Role of discoidin domain receptor 1 in T cell migration and arthritis, from 2020-01-01 to 2022-12-31

Recently finished projects

  • Profil moléculaire sanguin de patientes souffrant de lupus, from 2019-04-01 to 2021-03-31
Data provided by the Université Laval research projects registery