Dr. Fawzi Aoudjit is a senior scientist at the CHU de Québec Research Centre and a professor at the department of microbiology-infectiology and immunology of the Laval University School of Medicine. His research program seeks to understand the mechanisms controlling T cell activity in tissues during inflammatory/autoimmune diseases and cancer, with a focus on the role of the adhesion molecules that bind to extracellular matrix, the integrins. T cells play an important role in the adaptive immune response, but are also critical to the development of inflammatory diseases, and could become malignant and lead to cancer. Recent work by Dr. Aoudjit’s group significantly contributed to understand the importance of extracellular matrix-binding integrins in the regulation of T cell activation and the development of immune response. Along these lines, Dr. Aoudjit and his team have shown that the collagen-binding integrin alpha2beta1 is an important pathway in Th17 cell activation and in the development of arthritis. These studies were highlighted in the news bulletin ‘Immune regulation news’. Dr. Aoudjit received several acknowledgements for his work among which, the New Investigator Award from the Canadian Institutes of Health Research, in 2004.

The current objectives aim to

  1. understand how collagen receptors such as integrins and discoïdin domain receptors interact to promote the survival and migration of T cell subsets in inflammatory tissues; two critical T cell functions necessary to the development of inflammation, as well as to mounting an anti-cancer immune response.
  2. determine the role of integrins in the development of lymphoblastic leukemia by investigating their implication in the tissue dissemination of leukemic T cells, and in their resistance to chemotherapy; two cancer features that limit the efficacy of anti-cancer treatments.

The implication of these receptors in the development of inflammatory diseases and cancer is being investigated in human T cell models, in preclinical models of autoimmune diseases, leukemia, and in models of anti-cancer immunity, as well as at the clinical level with the collaboration of clinicians.

In addition to advancing knowledge, these studies aim at the discovery of novel therapeutic targets and treatments for autoimmune diseases and cancer.

CHUL
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2
60 entries « 1 of 6 »

Hamoudi C, Muheidli A, Aoudjit F

β1 Integrin induces adhesion and migration of human Th17 cells via Pyk2-dependent activation of P2X4 receptor

Journal Article

Immunology, 2022.

Abstract | Links:

Zhao Y, Aoudjit F, Bourgoin SG

Phospholipase A1 Member A Deficiency Alleviates Mannan-Induced Psoriatic Arthritis in Mice Model

Journal Article

Int J Mol Sci, 23 (15), 2022.

Abstract | Links:

Hamoudi C, Zhao C, Abderrazak A, Salem M, Fortin PR, Sévigny J, Aoudjit F

The Purinergic Receptor P2X4 Promotes Th17 Activation and the Development of Arthritis

Journal Article

J Immunol, 208 (5), 2022.

Abstract | Links:

Gamara J, Davis L, Leong AZ, Pagé N, Rollet-Labelle E, Zhao C, Hongu T, Funakoshi Y, Kanaho Y, Aoudji F, Pelletier M, Bourgoin SG

Corrigendum to "Arf6 regulates energy metabolism in neutrophils" [Free Radic Biol Med. 172 (2021) 550-561]

Journal Article

Free Radic Biol Med, 179 , 2022.

| Links:

Gamara J, Davis L, Leong AZ, Pagé N, Rollet-Labelle E, Zhao C, Hongu T, Funakoshi Y, Kanaho Y, Aoudji F, Pelletier M, Bourgoin SG

Arf6 regulates energy metabolism in neutrophils

Journal Article

Free Radic Biol Med, 172 , 2021.

Abstract | Links:

Berrazouane S, Doucet A, Boisvert M, Barabé F, Aoudjit F

VLA-4 Induces Chemoresistance of T Cell Acute Lymphoblastic Leukemia Cells via PYK2-Mediated Drug Efflux

Journal Article

Cancers (Basel), 13 (14), 2021.

Abstract | Links:

Defrêne J, Berrazouane S, Esparza N, Pagé N, Côté MF, Gobeil S, Aoudjit F, Tessier PA

Deletion of S100a8 and S100a9 Enhances Skin Hyperplasia and Promotes the Th17 Response in Imiquimod-Induced Psoriasis

Journal Article

J Immunol, 206 (3), 2021.

Abstract | Links:

Gamara J, Davis L, Rollet-Labelle E, Hongu T, Funakoshi Y, Kanaho Y, Aoudjit F, Bourgoin SG

Assessment of Arf6 Deletion in PLB-985 Differentiated in Neutrophil-Like Cells and in Mouse Neutrophils: Impact on Adhesion and Migration

Journal Article

Mediators Inflamm, 2020 , 2020.

Abstract | Links:

Bachsais M, Salti S, Zaoui K, Hassan GS, Aoudjit F, Mourad W

CD154 inhibits death of T cells via a Cis interaction with the α5β1 integrin

Journal Article

PLoS One, 15 (8), 2020.

Abstract | Links:

Salem M, El Azreq MA, Pelletier J, Robaye B, Aoudjit F, Sevigny J

Exacerbated intestinal inflammation in P2Y deficient mice is associated with Th17 activation

Journal Article

Biochim Biophys Acta Mol Basis Dis, 1865 (10), 2019.

Abstract | Links:

60 entries « 1 of 6 »
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Active projects

  • Expression and function of discoidin domain receptor 1 in T cells, from 2017-04-01 to 2026-03-31
  • Role of discoidin domain receptor 1 in T cell migration and arthritis, from 2020-01-01 to 2022-12-31
  • Uncovering the mechanisms of cell adhesion-induced chemoresistance in T cell acute lymphoblastic leukemia (T-ALL), from 2022-09-01 to 2024-08-31

Recently finished projects

  • Profil moléculaire sanguin de patientes souffrant de lupus, from 2019-04-01 to 2021-03-31
Data provided by the Université Laval research projects registery