Dr. Eric Biron, PhD, is a Regular Researcher at the CHU de Québec Research Center and Full Professor at the Faculty of Pharmacy of Laval University. Recognized for his contributions in peptide chemistry, combinatorial chemistry and antimicrobial peptides, Dr. Biron is particularly interested in the use of peptidomimetic macrocycles and heterocycles in medicinal chemistry. His research focuses on the discovery and development of novel therapeutic agents for the treatment of infectious diseases and cancers.

Discovery and development of new antibacterial agents

The alarming spread of antibiotic resistance has become a major problem in the treatment of bacterial infections. In this context, Dr. Biron is particularly interested in bacteriocins, a family of low molecular weight proteins produced by several bacteria, with strong antimicrobial activity. As they exhibit inhibitory activities against a large number of clinically important pathogenic bacteria, bacteriocins are increasingly considered as a promising substitute to antibiotics.

Based on their enormous potential in the pharmaceutical and medical areas, Dr. Biron’s laboratory is developing novel synthetic approaches to produce bacteriocins, and uses peptidomimetic strategies to optimize their pharmacological properties, improve their pharmacokinetic profile, and modify their spectrum of activity.

Development of new anti-cancer agents

Despite the progress made in various therapeutic approaches, the effectiveness of main anti-cancer therapies has reached a critical plateau in the treatment of several cancers. As a result, the demand for innovative and effective compounds with new modes of action is growing rapidly. In this context, Dr. Biron’s laboratory uses combinatorial chemistry to prepare libraries with high molecular diversity and perform target-based or phenotypic screenings to discover promising anti-cancer molecules.

In another approach, Dr. Biron is interested in the addiction of cancer cells to some multifunctional proteins that also play an important role in the resistance to treatment. In this case, Dr. Biron’s laboratory aims to develop functional inhibitors of these proteins through rational design, and peptidomimetic approaches.

CHUL
2705, boulevard Laurier
T4-50
Québec, Québec
Canada G1V 4G2
49 entries « 2 of 5 »

Bouyakdan K, Martin H, Lienard F, Budry L, Taib B, Rodaros D, Chretien C, Biron E, Husson Z, Cota D, Penicaud L, Fulton S, Fioramonti X, Alquier T

The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system

Journal Article

J Clin Invest, 129 (6), 2019.

Abstract | Links:

Jobin S, Beaumont C, Biron E

Development of a solid-phase traceless-Ugi multicomponent reaction for backbone anchoring and cyclic peptide synthesis

Journal Article

Pept Sci (Hoboken), 111 (1 (Special issue)), 2019.

| Links:

Bedard F, Fliss I, Biron E

Structure-Activity Relationships of the Bacteriocin Bactofencin A and Its Interaction with the Bacterial Membrane

Journal Article

ACS Infect Dis, 5 (2), 2019.

Abstract | Links:

Bedard F, Biron E

Recent Progress in the Chemical Synthesis of Class II and S-Glycosylated Bacteriocins

Journal Article

Front Microbiol, 9 , 2018.

Abstract | Links:

Bedard F, Hammami R, Zirah S, Rebuffat S, Fliss I, Biron E

Synthesis, antimicrobial activity and conformational analysis of the class IIa bacteriocin pediocin PA-1 and analogs thereof

Journal Article

Sci Rep, 8 (1), 2018.

Abstract | Links:

Vézina-Dawod S, Gerber N, Liang X, Biron E

Convenient two-step synthesis of highly functionalized benzo-fused 1,4-diazepin-3-ones and 1,5-diazocin-4-ones by sequential Ugi and intramolecular SNAr reactions

Journal Article

Tetrahedron, 44 , 2017.

| Links:

Biron É, Vézina-Dawod S, Bédard F

Synthetic Strategies for Macrocyclic Peptides

Book Chapter

Marsault E, Peterson ML (Ed.): Practical medicinal chemistry with macrocycles : design, synthesis, and case studies, pp. 207-241, Hoboken, NJ, Wiley, 2017, ISBN: 9781119092568.

| Links:

Liang X, Vezina-Dawod S, Bedard F, Porte K, Biron E

One-Pot Photochemical Ring-Opening/Cleavage Approach for the Synthesis and Decoding of Cyclic Peptide Libraries

Journal Article

Org Lett, 18 (5), 2016.

Abstract | Links:

Jobin S, Mejean A, Galindo SM, Liang X, Vezina-Dawod S, Biron E

Toward solid-phase peptide fragment ligation by a traceless-Ugi multicomponent reaction approach

Journal Article

Org Biomol Chem, 14 (47), 2016.

Abstract | Links:

Ennaas N, Hammami R, Gomaa A, Bedard F, Biron E, Subirade M, Beaulieu L, Fliss I

Collagencin, an antibacterial peptide from fish collagen: Activity, structure and interaction dynamics with membrane

Journal Article

Biochem Biophys Res Commun, 473 (2), 2016.

Abstract | Links:

49 entries « 2 of 5 »
Signaler des ajouts ou des modifications

Active projects

  • Dérivatisation de triterpènes naturels par réactions multicomposantes pour le développement de nouveaux composés bioactifs biosourcés, from 2023-08-15 to 2027-08-14
  • Étude des propriétés pharmacocinétiques de nouveaux dérivés de triterpènes biosourcés pour le contrôle de parasites protozoaires , from 2023-12-11 to 2024-12-11
  • New approaches for the design and synthesis of heterocyclic and macrocyclic bioactive peptidomimetics, from 2020-04-01 to 2025-03-31
  • Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines, from 2024-04-01 to 2030-03-31
  • Synthèse et étude structure-activité des bactériocines produites par Lacticaseibacillus paracasei CNCM I-5369, from 2024-05-06 to 2024-09-20

Recently finished projects

  • Développement de nouvelles molécules bioactives et d’acides aminés biosourcés par dérivatisation de triterpènes naturels, from 2022-05-01 to 2023-06-30
  • Exploiter l'addiction des bactéries au fer: Conception de nouvelles molécules hybrides bactériocine-sidérophore et évaluation de leur potentiel comme alternative aux antibiotiques, from 2021-04-01 to 2024-03-31
  • Institut sur la nutrition et les aliments fonctionnels (INAF), from 2017-04-01 to 2024-03-31
  • La conception de nouveaux agents thérapeutiques et la résonance magnétique nucléaire, from 2022-01-01 to 2023-05-31
  • Laboratoire de pointe en chimie peptidique et biomoléculaire pour la découverte et la conception de molécules bioactives, from 2022-04-01 to 2023-09-28
  • Valorisation de rejets de l'industrie forestière en molécules prometteuses pour le traitement de la malaria, from 2023-10-19 to 2024-03-31
  • Valorisation de triterpènes naturels par dérivatisation pour le développement de nouvelles molécules bioactives biosourcées, from 2021-11-15 to 2022-11-14
Data provided by the Université Laval research projects registery