Dr. Élodie Boisselier obtained her PhD from the University of Bordeaux (France) in 2009, during which she synthesized and functionalized gold nanoparticles and dendrimers for biomedical applications. She then completed a postdoctoral training at Laval University (Quebec, Canada) where she studied the biophysical behavior of membrane proteins involved in ocular diseases. She has received several awards and scholarships, including the prestigious Banting Fellowship, for her postdoctoral training. She joined the Ophthalmology Department as an Assistant Professor in 2014. Dr. Boisselier holds three patents and has over 20 publications to her credit, which have been cited more than 2,600 times. Her team pursues several research topics related to the field of ophthalmology.

One of their projects aims to study the membrane interaction of proteins found in the eye to better understand their physiological and pathological roles. For example, a project on S100 proteins and annexins is currently underway and aims to determine their mode of action in membrane repair, which is essential to cell survival.

In parallel, a membrane study of a pigment that accumulates in the eye, the A2E, is conducted to understand its involvement in the development of age-related macular degeneration (AMD).

Her team also aims to understand the interaction between proteins on the surface of the cornea, mucins, and gold nanoparticles, to optimize ophthalmic medication. Indeed, gold nanoparticles can be used as drug vectors to modulate their properties, and thus improve their retention on the ocular surface, and therefore their effectiveness.

Finally, another collaborative project uses gold nanoparticles to design probes that detect neurotransmitters, particularly those that are unbalanced in ocular pathologies.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
JS2-06
Québec, Québec
Canada G1S 4L8
48 entries « 5 of 5 »

Diallo AK, Boisselier E, Liang L, Ruiz J, Astruc D

Dendrimer-induced molecular catalysis in water: the example of olefin metathesis

Journal Article

Chemistry, 16 (39), 2010.

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Boisselier E, Diallo AK, Salmon L, Ornelas C, Ruiz J, Astruc D

Encapsulation and stabilization of gold nanoparticles with "click" polyethyleneglycol dendrimers

Journal Article

J Am Chem Soc, 132 (8), 2010.

Abstract | Links:

Astruc D, Boisselier E, Ornelas C

Dendrimers designed for functions: from physical, photophysical, and supramolecular properties to applications in sensing, catalysis, molecular electronics, photonics, and nanomedicine

Journal Article

Chem Rev, 110 (4), 2010.

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Boisselier E, Astruc D

Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity

Journal Article

Chem Soc Rev, 38 (6), 2009.

Abstract | Links:

Boisselier E, Ornelas C, Pianet I, Aranzaes JR, Astruc D

Four generations of water-soluble dendrimers with 9 to 243 benzoate tethers: synthesis and dendritic effects on their ion pairing with acetylcholine, benzyltriethylammonium, and dopamine in water

Journal Article

Chemistry, 14 (18), 2008.

Abstract | Links:

Boisselier E, Salmon L, Ruiz J, Astruc D

How to very efficiently functionalize gold nanoparticles by "click" chemistry

Journal Article

Chem Commun (Camb), (44), 2008.

Abstract | Links:

Boisselier E, Diallo AK, Salmon L, Ruiz J, Astruc D

Gold nanoparticles synthesis and stabilization via new "clicked" polyethyleneglycol dendrimers

Journal Article

Chem Commun (Camb), (39), 2008.

Abstract | Links:

Ornelas C, Boisselier E, Martinez V, Pianet I, Ruiz Aranzaes J, Astruc D

New water-soluble polyanionic dendrimers and binding to acetylcholine in water by means of contact ion-pairing interactions

Journal Article

Chem Commun (Camb), (47), 2007.

Abstract | Links:

48 entries « 5 of 5 »
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Active projects

  • Centre Québécois sur les Matériaux Fonctionnels (CQMF), from 2017-04-01 to 2024-03-31
  • Développement d’un outil de detection des mucines oculaires pour l’amélioration de la médication en ophtalmologie, from 2022-02-01 to 2024-03-31
  • École d'automne en matériaux durables du CERMA, from 2023-05-01 to 2024-04-30
  • Implication des protéines de la famille S100, des annexines et de leur complexe dans des processus membranaires, from 2022-04-01 to 2027-03-31
  • Mise en place d'une méthode protéomique ciblée afin de quantifier de nouveaux biomarqueurs de pathologies oculaires, from 2023-09-01 to 2024-03-31
  • Nouvelles nanotechnologies et plateformes pour le développement d’outils de thérapie et de diagnostic en ophtalmologie, from 2020-07-01 to 2024-06-30
  • Un nouveau vecteur de médicaments ophtalmiques à base de nanoparticules d'or, from 2020-10-01 to 2025-09-30
  • Une ultracentrifugeuse pour la préparation de protéines, acides nucléiques, mitochondries et vésicules lipidiques pour l'étude de leurs rôles physiologiques dans l'oeil, from 2023-03-31 to 2024-03-31

Recently finished projects

  • Développement d'une plateforme moléculaire de dosage des mucines oculaires pour l'amélioration de la médication en ophtalmologie, from 2019-04-01 to 2022-05-31
  • Développement d'une plateforme moléculaire pour le dosage de mucines oculaires, from 2022-01-02 to 2022-08-02
  • Développement d’un outil de détection des mucines oculaires pour l’amélioration de la médication en ophtalmologie, from 2022-05-01 to 2022-09-30
  • Implication des protéines de la famille S100, des annexines et de leur complexe dans les processus membranaires., from 2015-04-01 to 2022-03-31
  • Metal-Organic Frameworks for Applications in Ophthalmic Drug Delivery - Boisselier, from 2020-04-01 to 2022-03-31
  • PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), from 2015-04-01 to 2023-03-31
  • Vectorisation de médicaments anti-inflammatoires ophtalmiques, from 2020-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery