Dr. Élodie Boisselier obtained her PhD from the University of Bordeaux (France) in 2009, during which she synthesized and functionalized gold nanoparticles and dendrimers for biomedical applications. She then completed a postdoctoral training at Laval University (Quebec, Canada) where she studied the biophysical behavior of membrane proteins involved in ocular diseases. She has received several awards and scholarships, including the prestigious Banting Fellowship, for her postdoctoral training. She joined the Ophthalmology Department as an Assistant Professor in 2014. Dr. Boisselier holds three patents and has over 20 publications to her credit, which have been cited more than 2,600 times. Her team pursues several research topics related to the field of ophthalmology.

One of their projects aims to study the membrane interaction of proteins found in the eye to better understand their physiological and pathological roles. For example, a project on S100 proteins and annexins is currently underway and aims to determine their mode of action in membrane repair, which is essential to cell survival.

In parallel, a membrane study of a pigment that accumulates in the eye, the A2E, is conducted to understand its involvement in the development of age-related macular degeneration (AMD).

Her team also aims to understand the interaction between proteins on the surface of the cornea, mucins, and gold nanoparticles, to optimize ophthalmic medication. Indeed, gold nanoparticles can be used as drug vectors to modulate their properties, and thus improve their retention on the ocular surface, and therefore their effectiveness.

Finally, another collaborative project uses gold nanoparticles to design probes that detect neurotransmitters, particularly those that are unbalanced in ocular pathologies.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
JS2-06
Québec, Québec
Canada G1S 4L8
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Lachance GP, Boisselier É, Boukadoum M, Miled A

Towards an advanced neurotechnological system: colorimetric sensing with a novel grism-based spectrometer, functionalized gold nanoparticles and a heterogeneous embedded system

Journal Article

Philos Trans A Math Phys Eng Sci, 380 (2228), 2022.

Abstract | Links:

Lachance G, Boisselier É, Boukadoum M, Miled A

Molecular sensing system based on multi-technologies architecture

Book Chapter

GL, Côté (Ed.): Optical Diagnostics and Sensing XXII: Toward Point-of-Care Diagnostics (Proceedings of SPIE), pp. 1196807 (5 pages), Bellingham, WA, SPIE, 2022, ISBN: 9781510648074.

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Dikpati A, Gaudreault N, Chénard V, Grenier P, Boisselier É, Bertrand N

Size Exclusion of Radioactive Polymers (SERP) informs on the biodegradation of trimethyl chitosan and biodegradable polymer nanoparticles in vitro and in vivo

Journal Article

J Control Release, 346 , 2022.

Abstract | Links:

Kiseleva M, Omar MM, Boisselier É, Selivanova SV, Fortin MA

A Three-Dimensional Printable Hydrogel Formulation for the Local Delivery of Therapeutic Nanoparticles to Cervical Cancer

Journal Article

ACS Biomater Sci Eng, 8 (3), 2022.

Abstract | Links:

Guérin LP, Le-Bel G, Desjardins P, Couture C, Gillard E, Boisselier É, Bazin R, Germain L, Guérin SL

The Human Tissue-Engineered Cornea (hTEC): Recent Progress

Journal Article

Int J Mol Sci, 22 (3), 2021.

Abstract | Links:

Gauvreau D, Lachance GP, Landari H, Boisselier É, Boukadoum M, Messaddeq Y, Miled A

Finite Element Simulation of a Microdroplet Generation System for an Implantable Liquid Sampling Probe

Book Chapter

BioCAS 2021 - IEEE Biomedical Circuits and Systems Conference, Proceedings, 2021, pp. (4 pages), IEEE, 2021, ISBN: 9781728172057.

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Lachance GP, Boisselier É, Boukadoum M, Miled A

Assessment of a grism-based spectrometer design for neurotransmitter detection: preliminary results

Book Chapter

D, Fixler; EM, Goldys; S, Wachsmann-Hogiu (Ed.): Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVIII (Proceedings of SPIE), pp. 116580C (6 pages), Bellingham, WA, SPIE, 2021, ISBN: 9781510641518.

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Lachance GP, Soulard G, Bouffard L, Boisselier É, Boukadoum M, Miled A

Colorimetric Sensing System for Neurotransmitter Detection Based on Multi-technologies Architecture

Book Chapter

2021 28th IEEE International Conference on Electronics, Circuits and Systems (ICECS). Dubai, UAE (Nov 28-Dec 01), pp. (4 pages), Piscataway, NJ, IEEE, 2021, ISBN: 9781728182810.

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Niyonambaza SD, Koudrina A, DeRosa MC, Boukadoum M, Miled A, Boisselier E

Aptamer-Modified Ultrastable Gold Nanoparticles for Dopamine Detection

Journal Article

IEEE Sens J, 21 (3), 2021.

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Yan X, Kumar K, Miclette Lamarche R, Youssef H, Shaw GS, Marcotte I, DeWolf CE, Warschawski DE, Boisselier E

Interactions between the Cell Membrane Repair Protein S100A10 and Phospholipid Monolayers and Bilayers

Journal Article

Langmuir, 2021.

Abstract | Links:

45 entries « 1 of 5 »
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Active projects

  • Centre Québécois sur les Matériaux Fonctionnels (CQMF), from 2017-04-01 to 2024-03-31
  • Développement d'une plateforme moléculaire pour le dosage de mucines oculaires, from 2022-01-02 to 2022-08-02
  • Développement d’un outil de détection des mucines oculaires pour l’amélioration de la médication en ophtalmologie, from 2022-05-01 to 2022-09-30
  • Développement d’un outil de detection des mucines oculaires pour l’amélioration de la médication en ophtalmologie, from 2022-02-01 to 2023-03-31
  • Implication des protéines de la famille S100, des annexines et de leur complexe dans des processus membranaires, from 2022-04-01 to 2027-03-31
  • Nouvelles nanotechnologies et plateformes pour le développement d’outils de thérapie et de diagnostic en ophtalmologie, from 2020-07-01 to 2024-06-30
  • PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), from 2015-04-01 to 2023-03-31
  • Un nouveau vecteur de médicaments ophtalmiques à base de nanoparticules d'or, from 2020-10-01 to 2025-09-30

Recently finished projects

  • Développement d'une plateforme moléculaire de dosage des mucines oculaires pour l'amélioration de la médication en ophtalmologie, from 2019-04-01 to 2022-05-31
  • Évaluation de la biodistribution in vivo de nanoparticules d'or mucoadhésives et de leur capacité à vectoriser la combinaison synergique C646-SC79, pour accélérer la cicatrisation de plaies cornéennes, from 2020-08-01 to 2021-04-30
  • Implication des protéines de la famille S100, des annexines et de leur complexe dans les processus membranaires., from 2015-04-01 to 2022-03-31
  • Interactions nanoparticulaires et membranaires des protéines de l'oeil pour l'optimisation des thérapies en ophtalmologie., from 2016-07-01 to 2020-06-30
  • Metal-Organic Frameworks for Applications in Ophthalmic Drug Delivery - Boisselier, from 2020-04-01 to 2022-03-31
  • Vectorisation de médicaments anti-inflammatoires ophtalmiques, from 2020-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery