Dr. Donald Poirier has been a professor at the Department of Molecular Medicine (Faculty of Medicine, Laval University, Québec, Qc) since July 1991 as well as a researcher at the CHU de Québec – Research Center (Québec, Qc). Since 2008, he has also been Director of the Organic Synthesis Service and Co-Director of the Analytical and Medicinal Chemistry Platform.

Professor Poirier received his basic training in organic chemistry (PhD from Laval University, 1980-1985) and subsequently specialized in medicinal chemistry and endocrinology (Postdoctoral studies at the CHUL-Research Center, 1986-1990, CRM fellowship) and more recently in solid phase synthesis of small molecules of therapeutic interest such as steroid derivatives. He is especially interested in the development of steroidogenic enzyme (17b-HSDs, steroid sulfatase, CYP1B1) inhibitors and antitumor agents for the treatment of different cancers (breast, prostate, ovary, pancreatic, and leukemia). As examples, he developed the first non-estrogenic irreversible steroidal inhibitor of 17β-HSD1 for the treatment of breast cancer and endometriosis. He also developed a family of aminosteroid derivatives that inhibited tumor growth in mice for different cancers (breast, ovary, pancreatic, and leukemia).

In addition to the synthesis of small molecules by classical chemistry, he succeeded by developing solid-phase syntheses of C18-steroid (estrane) derivatives as well as C19-steroid (androstane) derivatives that enabled the generation of model libraries of targeted therapeutic compounds. Thus, he developed a diethylsilylacetylenic linker that produces more stable compounds and a sulfamate linker that produces two classes (phenol and sulfamate) of relevant steroidal or nonsteroidal compounds according to cleavage conditions. He is also interested in additional aspects of organic chemistry (synthesis, new methodologies, NMR analysis, etc.) and medicinal chemistry (SAR, molecular modeling, biological assays, etc.). A particularity of his research group is that he is interested in several stages of the development of a new drug: conception, chemical synthesis, in vitro biological tests (enzymatic assays, cell proliferation, etc.) and in vivo (estrogenic activities and androgenic in female and male mice, plasma concentration, metabolic stability, xenografts of cancer cells, etc.).

Professor Poirier has published 220 scientific publications and is the holder of 11 patents and patent applications. He has also been involved in more than 450 oral and poster presentations, as well as conferences as invited speaker.

2705, boulevard Laurier
Québec, Québec
Canada G1V 4G2
242 entries « 23 of 25 »

Auger S, Luu-The V, Sam KM, Poirier D

3-Hydroxy-19-nor-17?-pregna-1,3,5(10)-triene-21,17?-carbolactone as inhibitor of 17?-hydroxysteroid dehydrogenase type 2

Journal Article

Bioorg Med Chem Lett, 4 , 1994.

Pelletier JD, Poirier D

Bromination of alcohols by boron tribromide

Journal Article

Tetrahedron Lett, 35 , 1994.

Poirier D, Auger S, Mérand Y, Simard J, Labrie F

Synthesis and antiestrogenic activity of diaryl thioether derivatives

Journal Article

J Med Chem, 37 (8), 1994.

Abstract | Links:

Lautier D, Hoflack JC, Kirkland JB, Poirier D, Poirier GG

The role of poly(ADP-ribose) metabolism in response to active oxygen cytotoxicity

Journal Article

Biochim Biophys Acta, 1221 (3), 1994.

Abstract | Links:

Zee JA, Marin J, Poirier D, Cusson M, Roberge AG, Sévigny J

Valeurs nutritives de viandes et charcutrie produites et consommées au Québec

Journal Article

11 , 1993.

Zee JA, Carmichael L, Codere D, Poirier D, Fournier M

Effect of storage conditions on the stability of vitamin C in various fruits and vegetables produced and consumed in Quebec

Journal Article

J Food Compost Anal, 4 , 1991.

Poirier D, Mérand Y, Labrie F

Synthesis of 17beta-estradiol derivatives with N-butyl, N-methyl alkylamide side chain at position 15

Journal Article

Tetrahedron, 47 (37), 1991.

Poirier D, Labrie C, Mérand Y, Labrie F

Synthesis and biological activity of 17 alpha-alkynylamide derivatives of estradiol

Journal Article

J Steroid Biochem Mol Biol, 38 (6), 1991.

Abstract | Links:

Zee JA, Kouaouci R, Poirier D, Watier P

Effect of dietary fibers on chromium availability

Journal Article

8 , 1990.

Zee JA, Poirier D, Cusson M, Roberge AG, Sévigny J

Nutritional values of some fish and seafood produced and consomed in Quebec

Journal Article

23 , 1990.

242 entries « 23 of 25 »
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Active projects

  • 3alpha-hydroxysteroid dehydrogenase type 3 as a modulator of human adipose tissue function and distribution, from 2020-04-01 to 2024-03-31
  • Aminosteroid derivatives as a new class of cholesterol homeostasis disruptors for selective treatment of pancreatic cancer: Mechanistic and translational studies, from 2022-10-01 to 2027-09-30
  • Investigating TBC1D9 clinical relevance in combination with chemotherapeutic drugs in triple negative breast cancer, from 2023-06-21 to 2024-03-31
  • TBC1D9: therapeutic target of the aggressiveness of triple negative breast cancer, from 2023-03-01 to 2024-02-29

Recently finished projects

  • Évaluation du potentiel thérapeutique de la protectine DX et d'analogues contre la COVID-19 , from 2020-06-01 to 2022-03-31
  • La conception de nouveaux agents thérapeutiques et la résonance magnétique nucléaire, from 2022-01-01 to 2023-05-31
  • Un aminostéroïde actif oralement pour traiter les cancers du sein triple négatif, from 2021-09-08 to 2022-03-31
Data provided by the Université Laval research projects registery