I completed my doctorate in physiology-endocrinology at Laval University in May 2012. My studies, conducted under the supervision of Dr. Serge Rivest, focused on understanding the role of pro-inflammatory cytokine interleukin-1 beta in regulating neuronal activity in various brain-related pathologies. I then completed, from July 2012 to March 2017, a postdoctoral fellowship in epigenomics under the direction of Dr. Christopher Glass at the University of California, San Diego (UC San Diego). My studies helped me gain a better understanding of the molecular mechanisms that regulate transcription in human and murine microglia (see Gosselin et al., Cell, 2014, Gosselin et al., Science, 2017). Finally, since April 2017, I am assistant professor under grant at Laval University. My laboratory, located at the CHU of Quebec-Laval University Research Centre, aims to better understand the role of microglia in brain physiology.

Understanding the microglial cell

 Microglia are the immune cells of the brain. More and more evidence suggests that they are actually involved in various physiological aspects of brain tissue, including its development, or diseases such as Alzheimer’s and autism spectrum deficits. On the other hand, the way microglia activity is regulated at the molecular level remains poorly known as of today.

To address this problem, we are using state-of-the-art next-generation sequencing techniques to better understand how microglia integrate the various signals that regulate it at the genome level, and how this integration modulates gene expression and cellular functions in microglia. Our studies are conducted in mice and we improve our sequencing technologies using microscopy and animal behavior tests. Our multidisciplinary research program, unique in Canada, allows us to define with unmatched precision how microglia contribute to brain function.

CHUL
2705 Boulevard Laurier
T2-50
Ville de Québec, QC
Canada G1V 4G2
+1 418-525-4444, extension 46463
David.Gosselin@crchudeque...

Latest news

36 entries « ‹ 3 of 4 › »

Bellavance MA, Gosselin D, Yong VW, Stys PK, Rivest S

Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity

Journal Article

Brain Struct Funct, 220 (3), 2015.

Abstract | Links:

Link VM, Gosselin D, Glass CK

Mechanisms Underlying the Selection and Function of Macrophage-Specific Enhancers

Journal Article

Cold Spring Harb Symp Quant Biol, 80 , 2015.

Abstract | Links:

Crotti A, Benner C, Kerman BE, Gosselin D, Lagier-Tourenne C, Zuccato C, Cattaneo E, Gage FH, Cleveland DW, Glass CK

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

Journal Article

Nat Neurosci, 17 (4), 2014.

Abstract | Links:

Norris PC, Gosselin D, Reichart D, Glass CK, Dennis EA

Phospholipase A2 regulates eicosanoid class switching during inflammasome activation

Journal Article

Proc Natl Acad Sci U S A, 111 (35), 2014.

Abstract | Links:

Gosselin D, Glass CK

Epigenomics of macrophages

Journal Article

Immunol Rev, 262 (1), 2014.

Abstract | Links:

Gosselin D, Link VM, Romanoski CE, Fonseca GJ, Eichenfield DZ, Spann NJ, Stender JD, Chun HB, Garner H, Geissmann F, Glass CK

Environment drives selection and function of enhancers controlling tissue-specific macrophage identities

Journal Article

Cell, 159 (6), 2014.

Abstract | Links:

Gosselin D, Bellavance MA, Rivest S

IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults

Journal Article

Front Cell Neurosci, 7 , 2013.

Abstract | Links:

Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, Benner C, Kaikkonen MU, Kim AS, Kosaka M, Lee CY, Watt A, Grossman TR, Rosenfeld MG, Evans RM, Glass CK

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

Journal Article

Nature, 498 (7455), 2013.

Abstract | Links:

Boivin N, Menasria R, Gosselin D, Rivest S, Boivin G

Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis

Journal Article

J Gen Virol, 93 (Pt 6), 2012.

Abstract | Links:

Gosselin D, Rivest S

Immune mechanisms underlying the beneficial effects of autologous hematopoietic stem cell transplantation in multiple sclerosis

Journal Article

Neurotherapeutics, 8 (4), 2011.

Abstract | Links:

36 entries « ‹ 3 of 4 › »
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Active projects

  • Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in chronic neurodegenerative diseases, from 2020-03-01 to 2025-03-31
  • Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in demyelinating brain disorders, from 2021-04-01 to 2026-03-31
  • Enhancing microglial myelin repair mechanisms through stimulation of the Ppar-delta nuclear receptor as a novel therapeutic approach for multiple sclerosis, from 2020-09-01 to 2024-08-31
  • Étude des mécanismes de la régulation épigénétique et transcriptionelle responsables des fonctions des microglies dans le, from 2023-07-01 to 2025-06-30
  • Understanding and rejuvenating microglial phagocytosis as mean to inhibit progression of tauopathies in a mouse model of Alzheimer’s Disease, from 2020-10-01 to 2024-09-30

Recently finished projects

  • Aberrant microglial transcriptional regulation as an underlying core mechanism of disrupted brain development in ASD, from 2019-05-01 to 2022-04-30
  • Delineating the role of schizophrenia risk gene Mef2C in regulating microglial functions during brain development, from 2019-01-15 to 2022-01-14
  • Étude de criblage sur la reprogrammation du métabolisme, du micro-environnement tumoral et des cellules souches cancéreuses dans le médulloblastome, from 2021-05-01 to 2022-04-30
  • Étude des mécanismes de la régulation épigénétique et transcriptionnelle responsable des fonctions des microglies, from 2022-01-01 to 2022-11-23
Data provided by the Université Laval research projects registery