I completed my doctorate in physiology-endocrinology at Laval University in May 2012. My studies, conducted under the supervision of Dr. Serge Rivest, focused on understanding the role of pro-inflammatory cytokine interleukin-1 beta in regulating neuronal activity in various brain-related pathologies. I then completed, from July 2012 to March 2017, a postdoctoral fellowship in epigenomics under the direction of Dr. Christopher Glass at the University of California, San Diego (UC San Diego). My studies helped me gain a better understanding of the molecular mechanisms that regulate transcription in human and murine microglia (see Gosselin et al., Cell, 2014, Gosselin et al., Science, 2017). Finally, since April 2017, I am assistant professor under grant at Laval University. My laboratory, located at the CHU of Quebec-Laval University Research Centre, aims to better understand the role of microglia in brain physiology.

Understanding the microglial cell

 Microglia are the immune cells of the brain. More and more evidence suggests that they are actually involved in various physiological aspects of brain tissue, including its development, or diseases such as Alzheimer’s and autism spectrum deficits. On the other hand, the way microglia activity is regulated at the molecular level remains poorly known as of today.

To address this problem, we are using state-of-the-art next-generation sequencing techniques to better understand how microglia integrate the various signals that regulate it at the genome level, and how this integration modulates gene expression and cellular functions in microglia. Our studies are conducted in mice and we improve our sequencing technologies using microscopy and animal behavior tests. Our multidisciplinary research program, unique in Canada, allows us to define with unmatched precision how microglia contribute to brain function.

CHUL
2705 Boulevard Laurier
T2-50
Ville de Québec, QC
Canada G1V 4G2
+1 418-525-4444, extension 46463
David.Gosselin@crchudeque...

Latest news

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Seidman JS, Troutman TD, Sakai M, Gola A, Spann NJ, Bennett H, Bruni CM, Ouyang Z, Li RZ, Sun X, Vu BT, Pasillas MP, Ego KM, Gosselin D, Link VM, Chong LW, Evans RM, Thompson BM, McDonald JG, Hosseini M, Witztum JL, Germain RN, Glass CK

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

Journal Article

Immunity, 52 (6), 2020.

Abstract | Links:

Machado Xavier A, Belhocine S, Gosselin D

Essential contributions of enhancer genomic regulatory elements to microglial cell identity and functions

Journal Article

Wiley Interdiscip Rev Syst Biol Med, 11 (5), 2019.

Abstract | Links:

Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK

Brain cell type-specific enhancer-promoter interactome maps and disease-risk association

Journal Article

Science, 366 (6469), 2019.

Abstract | Links:

Schafer ST, Paquola ACM, Stern S, Gosselin D, Ku M, Pena M, Kuret TJM, Liyanage M, Mansour AA, Jaeger BN, Marchetto MC, Glass CK, Mertens J, Gage FH

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons

Journal Article

Nat Neurosci, 22 (2), 2019.

Abstract | Links:

Gyoneva S, Hosur R, Gosselin D, Zhang B, Ouyang Z, Cotleur AC, Peterson M, Allaire N, Challa R, Cullen P, Roberts C, Miao K, Reynolds TL, Glass CK, Burkly L, Ransohoff RM

Cx3cr1-deficient microglia exhibit a premature aging transcriptome

Journal Article

Life Sci Alliance, 2 (6), 2019.

Abstract | Links:

Gosselin D, Rivest S

Getting Too Old Too Quickly for Their Job: Senescent Glial Cells Promote Neurodegeneration

Journal Article

Neuron, 100 (4), 2018.

Abstract | Links:

Schlachetzki JCM, Prots I, Tao J, Chun HB, Saijo K, Gosselin D, Winner B, Glass CK, Winkler J

A monocyte gene expression signature in the early clinical course of Parkinson's disease

Journal Article

Sci Rep, 8 (1), 2018.

Abstract | Links:

Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK

An environment-dependent transcriptional network specifies human microglia identity

Journal Article

Science, 356 (6344), 2017.

Abstract | Links:

Allison KA, Sajti E, Collier JG, Gosselin D, Troutman TD, Stone EL, Hedrick SM, Glass CK

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

Journal Article

Elife, 5 , 2016.

Abstract | Links:

Eichenfield DZ, Troutman TD, Link VM, Lam MT, Cho H, Gosselin D, Spann NJ, Lesch HP, Tao J, Muto J, Gallo RL, Evans RM, Glass CK

Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages

Journal Article

Elife, 5 , 2016.

Abstract | Links:

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Active projects

  • Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in chronic neurodegenerative diseases, from 2020-03-01 to 2025-03-31
  • Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in demyelinating brain disorders, from 2021-04-01 to 2026-03-31
  • Étude des mécanismes de la régulation épigénétique et transcriptionelle responsables des fonctions des microglies dans le, from 2023-07-01 to 2025-06-30
  • Understanding and rejuvenating microglial phagocytosis as mean to inhibit progression of tauopathies in a mouse model of Alzheimer’s Disease, from 2020-10-01 to 2025-09-30

Recently finished projects

  • Enhancing microglial myelin repair mechanisms through stimulation of the Ppar-delta nuclear receptor as a novel therapeutic approach for multiple sclerosis, from 2020-09-01 to 2024-08-31
  • Étude des mécanismes de la régulation épigénétique et transcriptionnelle responsable des fonctions des microglies, from 2022-01-01 to 2024-08-31
Data provided by the Université Laval research projects registery