Christian Salesse is a full-time researcher at the Centre de recherche du CHU de Québec – Laval University, and full professor in Laval University’s Department of Ophthalmology. He graduated in biophysics from Université du Québec à Trois-Rivières (UQTR). He was then a postdoctoral fellow at the Johannes-Gutenberg Universität in Mainz, Germany. He then became professor at the UQTR for 14 years until he moved on to work at Laval University, in 2002. He has been a fellow from Fonds de Recherche – Québec Santé (FRQS) from the Junior 1 to the National level. He has also been Adjunct Professor at Jilin University in Changchun, China since 1995. He was an invited professor at several universities in France and Portugal.

His expertise is in the field of visual phototransduction and visual cycle, and the proteins involved in these processes. These processes require the binding of most of these proteins to membranes. We therefore perform membrane binding measurements of proteins. We are using simple model membranes such as lipid monolayers and bilayers to characterize their membrane binding. Protein binding to monolayers of saturated and highly polyunsaturated neutral or negatively charged lipids, that are typical of photoreceptors, is characterized by performing measurements of maximum insertion pressure, fluorescence microscopy, ellipsometry, as well as infrared spectroscopy (PM-IRRAS which also allows to determine protein orientation). Steady state fluorescence spectroscopy and fluorescence lifetime are used to characterize protein binding to lipid bilayers. The proteins we are studying also often have enzymatic activities; we have thus developed methods to characterize the activity of some of these enzymes. Moreover, we use nuclear magnetic resonance to determine the structure of a protein involved in the visual cycle.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
CUO-Recherche
K2-02
Québec, Québec
Canada G1S 4L8
125 entries « 2 of 13 »

Potvin-Fournier K, Valois-Paillard G, Lefevre T, Cantin L, Salesse C, Auger M

Membrane fluidity is a driving force for recoverin myristoyl immobilization in zwitterionic lipids

Journal Article

Biochem Biophys Res Commun, 490 (4), 2017.

Abstract | Links:

Boisselier E, Demers E, Cantin L, Salesse C

How to gather useful and valuable information from protein binding measurements using Langmuir lipid monolayers

Journal Article

Adv Colloid Interface Sci, 243 , 2017.

Abstract | Links:

Salesse C

[Physiology of the visual retinal signal: From phototransduction to the visual cycle]

Journal Article

J Fr Ophtalmol, 40 (3), 2017.

Abstract | Links:

Salesse C

Physiologie du signal visuel rétinien : de la phototransduction jusqu’au cycle visuel

Book Chapter

EM| consulte. Ophtalmologie, 13 , pp. [Article 21-026-K-10], Issy les Moulineaux, Elsevier Masson SAS, 2016.

Potvin-Fournier K, Lefevre T, Picard-Lafond A, Marcotte C, Dufresne C, Cantin L, Salesse C, Auger M

Discriminating Lipid- from Protein-Calcium Binding To Understand the Interaction between Recoverin and Phosphatidylglycerol Model Membranes

Journal Article

Biochemistry, 55 (24), 2016.

Abstract | Links:

Calvez P, Schmidt TF, Cantin L, Klinker K, Salesse C

Phosphatidylserine Allows Observation of the Calcium-Myristoyl Switch of Recoverin and Its Preferential Binding

Journal Article

J Am Chem Soc, 138 (41), 2016.

Abstract | Links:

Lake J, Zaniolo K, Gingras ME, Couture C, Salesse C, Guerin SL

Functional Impact of Collagens on the Activity Directed by the Promoter of the α5 Integrin Subunit Gene in Corneal Epithelial Cells

Journal Article

Invest Ophthalmol Vis Sci, 56 (11), 2015.

Abstract | Links:

Bernier SC, Demers É, Cantin L, Bussières S, Salesse C

How To Decipher Protein and Peptide Selectivity for Lipids in Monolayers

Book Chapter

Wang C, Leblanc RM (Ed.): Recent Progress in Colloid and Surface Chemistry with Biological Applications, 1215 , pp. 109-128, American Chemical Society, 2015, ISBN: 9780841231207.

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Bernier S, Horchani H, Salesse C

Structure and binding of the C-terminal segment of R9AP to lipid monolayers

Journal Article

Langmuir, 31 (6), 2015.

Abstract | Links:

Duval C, Zaniolo K, Leclerc S, Salesse C, Guerin SL

Characterization of the human α9 integrin subunit gene: Promoter analysis and transcriptional regulation in ocular cells

Journal Article

Exp Eye Res, 135 , 2015.

Abstract | Links:

125 entries « 2 of 13 »
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Active projects

  • A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease, from 2021-10-01 to 2026-09-30
  • Implication de diverses protéines dans la fonction des photorécepteurs visuels, from 2023-04-01 to 2028-03-31
  • Journée annuelle de la recherche en ophtalmologie , from 2019-04-23 to 2025-03-31
  • Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines, from 2024-04-01 to 2030-03-31

Recently finished projects

  • Caractérisation de la liaison membranaire de la rhodopsine kinase, from 2023-01-15 to 2023-06-10
  • Implication de diverses protéines dans la fonction des photorécepteurs visuels, from 2017-04-01 to 2023-03-31
  • PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), from 2015-04-01 to 2023-03-31
Data provided by the Université Laval research projects registery