Christian Salesse is a full-time researcher at the Centre de recherche du CHU de Québec – Laval University, and full professor in Laval University’s Department of Ophthalmology. He graduated in biophysics from Université du Québec à Trois-Rivières (UQTR). He was then a postdoctoral fellow at the Johannes-Gutenberg Universität in Mainz, Germany. He then became professor at the UQTR for 14 years until he moved on to work at Laval University, in 2002. He has been a fellow from Fonds de Recherche – Québec Santé (FRQS) from the Junior 1 to the National level. He has also been Adjunct Professor at Jilin University in Changchun, China since 1995. He was an invited professor at several universities in France and Portugal.

His expertise is in the field of visual phototransduction and visual cycle, and the proteins involved in these processes. These processes require the binding of most of these proteins to membranes. We therefore perform membrane binding measurements of proteins. We are using simple model membranes such as lipid monolayers and bilayers to characterize their membrane binding. Protein binding to monolayers of saturated and highly polyunsaturated neutral or negatively charged lipids, that are typical of photoreceptors, is characterized by performing measurements of maximum insertion pressure, fluorescence microscopy, ellipsometry, as well as infrared spectroscopy (PM-IRRAS which also allows to determine protein orientation). Steady state fluorescence spectroscopy and fluorescence lifetime are used to characterize protein binding to lipid bilayers. The proteins we are studying also often have enzymatic activities; we have thus developed methods to characterize the activity of some of these enzymes. Moreover, we use nuclear magnetic resonance to determine the structure of a protein involved in the visual cycle.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
CUO-Recherche
K2-02
Québec, Québec
Canada G1S 4L8
125 entries « 13 of 13 »

Ducharme D, Salesse C, Leblanc RM

Ellipsometric studies of rod outer segment phospholipids at the nitrogen-water interface

Journal Article

Thin Solid Films, 132 (1-4), 1985.

Abstract | Links:

N'Soukpoé-Kossi CN, Salesse C, Leblanc RM, Boucher F

Molar absorptivities of bovine retina rod outer segment phospholipids in n-hexane

Journal Article

Anal Biochem, 151 (2), 1985.

Abstract | Links:

Salesse C, Boucher F, Leblanc RM

An evaluation of purity criteria for bovine rod outer segment membranes

Journal Article

Anal Biochem, 142 (2), 1984.

Abstract | Links:

Salesse C, Boucher F, Leblanc RM

[Surface properties of phospholipids of the retinal rod membrane]

Journal Article

Rev Can Biol Exp, 42 (2), 1983.

Abstract | Links:

Robert S, Tancrède P, Salesse C, Leblanc RM

Interactions in mixed monolayers between distearoyl-L-phosphatidylethanolamine, rod outer segment phosphatidylethanolamine and all-trans retinal. Effect of pH

Journal Article

Biochim Biophys Acta, 730 (2), 1983.

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125 entries « 13 of 13 »
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Active projects

  • A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease, from 2021-10-01 to 2026-09-30
  • Caractérisation de la liaison membranaire de la rhodopsine kinase, from 2023-01-15 to 2023-06-10
  • Implication de diverses protéines dans la fonction des photorécepteurs visuels, from 2023-04-01 to 2028-03-31
  • Journée annuelle de la recherche en ophtalmologie , from 2019-04-23 to 2025-03-31

Recently finished projects

  • Déterminants moléculaires de la lécithine rétinol acyltransférase responsables de la dégénérescence des photorécepteurs, from 2016-07-01 to 2021-06-30
  • Implication de diverses protéines dans la fonction des photorécepteurs visuels, from 2017-04-01 to 2023-03-31
  • PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), from 2015-04-01 to 2023-03-31
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