Caroline Sirois is a professor in the Department of Social and Preventive Medicine at Laval University. She is a researcher at the CHU de Québec Research Center, the Center of Excellence on Aging in Quebec, the Center for Research in Primary Care and Services at Laval University, and a research associate at the Institut national de santé publique du Québec (INSPQ). Since July 2016, she holds the Chair of Research on Aging at Laval University. As a pharmacist with a master’s degree in hospital pharmacy, Ms. Sirois practiced in community pharmacies and hospital settings before completing a master’s degree and a doctorate in pharmacoepidemiology at Laval University. She then completed postdoctoral training in epidemiology at McGill University.

Her research interests focus on the appropriate use of drugs in older adults, polypharmacy, and deprescribing. Her interests include the study of potentially inappropriate drugs for older individuals and the conceptualization of appropriate polypharmacy. By using multicriteria analysis methods, she tries to determine which drug combinations generate more benefits than adverse effects on the health and quality of life of patients. She is also interested in deprescribing, both from the perspective of older adults, and clinicians.

Ms. Sirois works closely with the INSPQ on the development of polypharmacy surveillance for people aged 65 and over in Quebec. This project involves the development of polypharmacy indicators on which she collaborates with several international teams.

  • Campeau Calfat, AlexandreDoctoral student

  • Gagnon, Marie-ÈveDoctoral student
    Hôpital Saint-Sacrement
    1050 Chemin Sainte-Foy
    Québec, QC
    Canada G1S 4L8
  • Guay, Charles-AntoineDoctoral student

  • Simard, MarcDoctoral student

113 entries « 1 of 12 »

Mésidor M, Sirois C, Guertin JR, Schnitzer ME, Candas B, Blais C, Cossette B, Poirier P, Brophy JM, Lix L, Tadrous M, Diop A, Hamel D, Talbot D

Effect of statin use for the primary prevention of cardiovascular disease among older adults: a cautionary tale concerning target trials emulation

Journal Article

J Clin Epidemiol, 168 , 2024.

Abstract | Links:

Arsenault-Lapierre G, Godard-Sebillotte C, Bui T, Sourial N, Rochette L, Massamba V, Sirois C, Kosteniuk J, Morgan D, Quesnel-Vallée A, Vedel I

Rural-Urban Differences in Healthcare Use in Persons With Dementia Between 2000 and 2019: A Quebec Population-Based Study

Journal Article

Healthc Policy, 19 (3), 2024.

Abstract | Links:

Sirois C, Gosselin M, Laforce C, Gagnon ME, Talbot D

How does deprescribing (not) reduce mortality? A review of a meta-analysis in community-dwelling older adults casts uncertainty over claimed benefits

Journal Article

Basic Clin Pharmacol Toxicol, 134 (1), 2024.

Abstract | Links:

Gosselin M, Baroud ML, Denis OR, Gagnon ME, Sirois C

Evidence-based data for newly approved medications' use in older adults: An analysis from clinical trials to monographs

Journal Article

J Am Geriatr Soc, 72 (4), 2024.

Abstract | Links:

Dean T, Koné A, Martin L, Armstrong J, Sirois C

Understanding the Extent of Polypharmacy and its Association With Health Service Utilization Among Persons With Cancer and Multimorbidity: A Population-Based Retrospective Cohort Study in Ontario, Canada

Journal Article

J Pharm Pract, 37 (1), 2024.

Abstract | Links:

Gagnon ME, Talbot D, Tremblay F, Desforges K, Sirois C

Polypharmacy and risk of fractures in older adults: A systematic review

Journal Article

J Evid Based Med, 17 (1), 2024.

Abstract | Links:

Campeau Calfat A, Roger É, Sirois C

[Programme d'été sur le vieillissement de l'Institut du vieillissement des Instituts de Recherche en Santé du Canada : trois pistes de réflexion de participants du Québec]

Journal Article

Can J Aging, 2024.

Abstract | Links:

Campeau Calfat A, Sirois C

Identifying Frailty in Administrative Databases: A Narrative Review

Journal Article

J Frailty Aging, 13 (2), 2024.

Abstract | Links:

Ly A, Sirois C, Dionne CE

Sensitivity and specificity of algorithms for the identification of nonspecific low back pain in medico-administrative databases

Journal Article

Pain, 164 (7), 2023.

Abstract | Links:

Austin N, Rudoler D, Allin S, Dolovich L, Glazier RH, Grudniewicz A, Martin E, Sirois C, Strumpf E

Team-based primary care reforms and older adults: a descriptive assessment of sociodemographic trends and prescribing endpoints in two Canadian provinces

Journal Article

BMC Prim Care, 24 (1), 2023.

Abstract | Links:

113 entries « 1 of 12 »
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Active projects

  • Déterminants socio-économiques des troubles cognitifs chez les patientes avec cancer du sein métastatique, from 2024-01-01 to 2026-12-31
  • Favoriser l'engagement des femmes ayant eu un cancer du sein dans les décisions concernant l'hormonothérapie adjuvante prolongée, from 2023-10-01 to 2027-05-31
  • Polymédication et usage approprié des médicaments chez les aînés québécois, from 2021-07-01 to 2024-06-30
  • Projet GPS: Évaluation de l'impact de la réorganisation du travail en Groupe de médecine de famille (GMF) sur la Pharmacothérapie et le Soutien à l'autonomie des personnes âgées ayant un trouble neuro-cognitif majeur, from 2019-04-01 to 2025-03-31

Recently finished projects

  • Association entre les taux d’utilisation des antibiotiques et la fréquence des gènes de résistance aux antibiotiques dans les eaux usées de la région de Laval pendant la pandémie COVID-19, from 2023-02-08 to 2024-03-31
  • Co-construction d'un Living lab au sein des maisons des aînés et alternatives, from 2022-05-01 to 2023-04-30
  • Démarrage d'un nouveau professeur, from 2020-01-01 to 2023-12-31
  • Déterminer la qualité de la polypharmacie chez les aînés : une approche basée sur l’intelligence artificielle, from 2020-04-01 to 2023-03-31
  • Impacts de la pandémie sur la consommation de médicaments et la polypharmacie par le régime public d’assurance médicaments du Québec dans la population assurée, from 2022-03-16 to 2024-03-31
  • Maison des aînés : étude d'un modèle d'habitation innovant dans une perspective de relance de l'économie et de progrès de notre société suite à la pandémie de COVID-19., from 2021-04-01 to 2022-05-31
  • Maisons des aînés et maisons alternatives : étude observationnelle de la transition et de l'intégration des nouveaux résidents dans ce nouvel hébergement, from 2022-03-16 to 2023-03-31
  • Optimisation 2.0 de la prise en charge en phase aiguë des fractures de la hanche chez l’aîné , from 2022-04-01 to 2023-03-31
  • Pharmacie sans médicaments: exploration des impacts des services cliniques offerts aux aînés québécois polymédicamentés, from 2021-02-19 to 2024-03-31
  • Phase Two of the Canadian Consortium on Neurodegeneration in Aging, from 2019-04-01 to 2024-03-31
  • Primary care reform and medication appropriateness for seniors: A comparative study of two provinces, from 2018-04-01 to 2024-03-31
  • Real-World Evaluation of the Efficacy, Safety and Cost-Effectiveness of Statins for Primary Prevention of Cardiovascular Disease Among the Elderly – A Causal Perspective to Treatment Trajectory Analysis, from 2019-10-01 to 2023-03-31
  • Suivi de la qualité de la pratique de l'électroconvulsivothérapie au Québec basé sur le recueil de données médico-administratives, cliniques et socio-démographiques en contexte réel, from 2020-01-01 to 2023-09-30
Data provided by the Université Laval research projects registery