In addition to being a regular researcher at the CHU of Quebec-Laval University Research Centre, and Associate Professor in the Department of Microbiology, Infectiology and Immunology of the Faculty of Medicine at Laval University, Dr. Gilbert is Program Director of postgraduate studies in microbiology and immunology at Laval University.

Since 2008, Dr. Gilbert has pursued two lines of research that fit perfectly with the priorities of the infectious and immune diseases axis: the study of the role of extracellular vesicles (EVs), including exosomes, and that of the lectin DCIR (Dendritic Cell Immunoreceptor) in the early stages of Human Immunodeficiency Virus-1 (HIV-1) infection as well as in immune response disorders in infected patients.

Dendritic cells (DCs) are among the first cells to internalize the virus and orchestrate the immune response. They migrate to the secondary lymphoid organs where the internalized virus is transmitted to LTCD4s, causing, among other things, the apoptosis of these cells, as well as the development of a less effective immune response. Dr. Gilbert has been actively involved in early studies demonstrating the role of C-type lectin, DCIR (Dendritic Cell Immunoreceptor) in viral attachment, as well as in the transfer of apoptotic CDs or LTCD4s virus to other LTCD4s. Through these studies, three patents were obtained, and the benefits of these discoveries continue to be reaped in her laboratory. She has also shown that, following viral infection, CDs can release EVs, which act as intercellular communicators. These EVs, which are found in biological fluids, have also allowed her team to identify miR-155, a microRNA with a broad immunomodulatory potential, in the plasmas of HIV-1 patients. She demonstrated that the release of EVs by CDs involves the activation of DCIR. Her research program, based on these observations, therefore includes both a fundamental and translational aspect. Indeed, the development of therapeutic strategies blocking the interaction of DCIR with HIV-1, and consequently the release of EVs with immunosuppressive properties, may help to understand the early events of HIV-1 infection and lead to the design and development of new therapeutic tools. Finally, EVs are considered to play an important role in cell communication and transformation, as well as being potential biomarkers of immune activation in HIV-1 patients. In recent years, enthusiasm for these vesicles can be explained by their strong theranostic potential, and Dr. Gilbert’s laboratory differentiates itself by the biochemical methods she develops to better characterize them.

CHUL
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Québec, Québec
Canada G1V 4G2
40 entries « 4 of 4 »

Leclerc P, Biarc J, St-Onge M, Gilbert C, Dussault AA, Laflamme C, Pouliot M

Nucleobindin co-localizes and associates with cyclooxygenase (COX)-2 in human neutrophils

Journal Article

PLoS One, 3 (5), 2008.

Abstract | Links:

Cantin R, Diou J, Belanger D, Tremblay AM, Gilbert C

Discrimination between exosomes and HIV-1: purification of both vesicles from cell-free supernatants

Journal Article

J Immunol Methods, 338 (1-2), 2008.

Abstract | Links:

Barat C, Gilbert C, Imbeault M, Tremblay MJ

Extracellular ATP reduces HIV-1 transfer from immature dendritic cells to CD4+ T lymphocytes

Journal Article

Retrovirology, 5 , 2008.

Abstract | Links:

Lambert AA, Gilbert C, Richard M, Beaulieu AD, Tremblay MJ

The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways

Journal Article

Blood, 112 (4), 2008.

Abstract | Links:

Gilbert C, Cantin R, Barat C, Tremblay MJ

Human immunodeficiency virus type 1 replication in dendritic cell-T-cell cocultures is increased upon incorporation of host LFA-1 due to higher levels of virus production in immature dendritic cells

Journal Article

J Virol, 81 (14), 2007.

Abstract | Links:

Martin G, Roy J, Barat C, Ouellet M, Gilbert C, Tremblay MJ

Human immunodeficiency virus type 1-associated CD40 ligand transactivates B lymphocytes and promotes infection of CD4+ T cells

Journal Article

J Virol, 81 (11), 2007.

Abstract | Links:

Gilbert C, Barat C, Cantin R, Tremblay MJ

Involvement of Src and Syk tyrosine kinases in HIV-1 transfer from dendritic cells to CD4+ T lymphocytes

Journal Article

J Immunol, 178 (5), 2007.

Abstract | Links:

Thibault S, Tardif MR, Gilbert C, Tremblay MJ

Virus-associated host CD62L increases attachment of human immunodeficiency virus type 1 to endothelial cells and enhances trans infection of CD4+ T lymphocytes

Journal Article

J Gen Virol, 88 (Pt 9), 2007.

Abstract | Links:

Popa-Nita O, Rollet-Labelle E, Thibault N, Gilbert C, Bourgoin SG, Naccache PH

Crystal-induced neutrophil activation. IX. Syk-dependent activation of class Ia phosphatidylinositol 3-kinase

Journal Article

J Leukoc Biol, 82 (3), 2007.

Abstract | Links:

Barabé F, Rollet-Labelle E, Gilbert C, Fernandes MJ, Naccache SN, Naccache PH

Early events in the activation of Fc gamma RIIA in human neutrophils: stimulated insolubilization, translocation to detergent-resistant domains, and degradation of Fc gamma RIIA

Journal Article

J Immunol, 168 (8), 2002.

Abstract | Links:

40 entries « 4 of 4 »
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Active projects

  • Deciphering the role of DCIR in HIV-1 pathogenesis, from 2018-04-01 to 2023-03-31
  • Immunité cellulaire et séroprévalence des anticorps contre SARS-COV-2: Caratérisation de trois populations de travailleurs de l'alimentation, from 2020-11-01 to 2023-03-31
  • Surveillance des réponses immunitaires au vaccin contre la COVID-19 chez les personnes vivant avec le VIH-1, from 2021-12-01 to 2022-11-30

Recently finished projects

  • Détermination du rôle de DCIR dans la pathogenèse associée à l’infection par le VIH-1, from 2020-07-10 to 2020-11-09
  • Discovery of Novel Extracellular Vesicle Biomarkers for the Early Detection of Alzheimer's Disease, from 2020-03-31 to 2022-03-30
  • Efficacité in vivo de quatre antagonistes du DCIR à limiter l’infection par le VIH-1, from 2020-02-03 to 2020-12-31
  • Un banc de test à haute sensibilité pour mesurer la diffusion de virus à travers les matériaux constituant les équipements de protection individuels (gants), from 2020-09-21 to 2021-09-21
Data provided by the Université Laval research projects registery