In addition to being a regular researcher at the CHU of Quebec-Laval University Research Centre, and Associate Professor in the Department of Microbiology, Infectiology and Immunology of the Faculty of Medicine at Laval University, Dr. Gilbert is Program Director of postgraduate studies in microbiology and immunology at Laval University.
Since 2008, Dr. Gilbert has pursued two lines of research that fit perfectly with the priorities of the infectious and immune diseases axis: the study of the role of extracellular vesicles (EVs), including exosomes, and that of the lectin DCIR (Dendritic Cell Immunoreceptor) in the early stages of Human Immunodeficiency Virus-1 (HIV-1) infection as well as in immune response disorders in infected patients.
Dendritic cells (DCs) are among the first cells to internalize the virus and orchestrate the immune response. They migrate to the secondary lymphoid organs where the internalized virus is transmitted to LTCD4s, causing, among other things, the apoptosis of these cells, as well as the development of a less effective immune response. Dr. Gilbert has been actively involved in early studies demonstrating the role of C-type lectin, DCIR (Dendritic Cell Immunoreceptor) in viral attachment, as well as in the transfer of apoptotic CDs or LTCD4s virus to other LTCD4s. Through these studies, three patents were obtained, and the benefits of these discoveries continue to be reaped in her laboratory. She has also shown that, following viral infection, CDs can release EVs, which act as intercellular communicators. These EVs, which are found in biological fluids, have also allowed her team to identify miR-155, a microRNA with a broad immunomodulatory potential, in the plasmas of HIV-1 patients. She demonstrated that the release of EVs by CDs involves the activation of DCIR. Her research program, based on these observations, therefore includes both a fundamental and translational aspect. Indeed, the development of therapeutic strategies blocking the interaction of DCIR with HIV-1, and consequently the release of EVs with immunosuppressive properties, may help to understand the early events of HIV-1 infection and lead to the design and development of new therapeutic tools. Finally, EVs are considered to play an important role in cell communication and transformation, as well as being potential biomarkers of immune activation in HIV-1 patients. In recent years, enthusiasm for these vesicles can be explained by their strong theranostic potential, and Dr. Gilbert’s laboratory differentiates itself by the biochemical methods she develops to better characterize them.
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- [Radio-Canada] Étude sur la COVID-19 chez les travailleurs du secteur du détail 2021-06-16
- [Université Laval] Vaste étude pour mesurer les effets de la COVID-19 sur les travailleurs de l’alimentation 2021-03-18
- 13 chercheurs du Centre de recherche du CHU de Québec-Université Laval obtiennent 7,6M$ au programme Projet des IRSC 2018-01-26
Vesicular MicroRNA as Potential Biomarkers of Viral ReboundJournal Article
Cells, 11 (5), 2022.
Immunovirological discordance among female sex workers who start antiretroviral therapy in Burkina FasoJournal Article
BMC Infect Dis, 22 (1), 2022.
Plasma Extracellular Vesicle Subtypes May be Useful as Potential Biomarkers of Immune Activation in People With HIVJournal Article
Pathog Immun, 6 (1), 2021.
Diurnal Variation of Plasma Extracellular Vesicle Is Disrupted in People Living with HIVJournal Article
Pathogens, 10 (5), 2021.
Velocity Gradient Separation Reveals a New Extracellular Vesicle Population Enriched in miR-155 and Mitochondrial DNAJournal Article
Pathogens, 10 (5), 2021.
Isolating Multiple Extracellular Vesicles Subsets, Including Exosomes and Membrane Vesicles, from Bovine Milk Using Sodium Citrate and Differential UltracentrifugationJournal Article
Bio Protoc, 10 (11), 2020.
Platelets Disseminate Extracellular Vesicles in Lymph in Rheumatoid ArthritisJournal Article
Arterioscler Thromb Vasc Biol, 40 (4), 2020.
Endogenous retrovirus-encoded Syncytin-2 contributes to exosome-mediated immunosuppression of T cells†Journal Article
Biol Reprod, 102 (1), 2020.
Concentrates of two subsets of extracellular vesicles from cow's milk modulate symptoms and inflammation in experimental colitisJournal Article
Sci Rep, 9 (1), 2019.
Identification of protein markers for extracellular vesicle (EV) subsets in cow's milkJournal Article
J Proteomics, 192 , 2019.
- Deciphering the role of DCIR in HIV-1 pathogenesis, from 2018-04-01 to 2023-03-31
- Immunité cellulaire et séroprévalence des anticorps contre SARS-COV-2: Caratérisation de trois populations de travailleurs de l'alimentation, from 2020-11-01 to 2023-03-31
- Surveillance des réponses immunitaires au vaccin contre la COVID-19 chez les personnes vivant avec le VIH-1, from 2021-12-01 to 2022-11-30
Recently finished projects
- Détermination du rôle de DCIR dans la pathogenèse associée à l’infection par le VIH-1, from 2020-07-10 to 2020-11-09
- Discovery of Novel Extracellular Vesicle Biomarkers for the Early Detection of Alzheimer's Disease, from 2020-03-31 to 2022-03-30
- Efficacité in vivo de quatre antagonistes du DCIR à limiter l’infection par le VIH-1, from 2020-02-03 to 2020-12-31
- Un banc de test à haute sensibilité pour mesurer la diffusion de virus à travers les matériaux constituant les équipements de protection individuels (gants), from 2020-09-21 to 2021-09-21