In addition to being a regular researcher at the CHU of Quebec-Laval University Research Centre, and Associate Professor in the Department of Microbiology, Infectiology and Immunology of the Faculty of Medicine at Laval University, Dr. Gilbert is Program Director of postgraduate studies in microbiology and immunology at Laval University.

Since 2008, Dr. Gilbert has pursued two lines of research that fit perfectly with the priorities of the infectious and immune diseases axis: the study of the role of extracellular vesicles (EVs), including exosomes, and that of the lectin DCIR (Dendritic Cell Immunoreceptor) in the early stages of Human Immunodeficiency Virus-1 (HIV-1) infection as well as in immune response disorders in infected patients.

Dendritic cells (DCs) are among the first cells to internalize the virus and orchestrate the immune response. They migrate to the secondary lymphoid organs where the internalized virus is transmitted to LTCD4s, causing, among other things, the apoptosis of these cells, as well as the development of a less effective immune response. Dr. Gilbert has been actively involved in early studies demonstrating the role of C-type lectin, DCIR (Dendritic Cell Immunoreceptor) in viral attachment, as well as in the transfer of apoptotic CDs or LTCD4s virus to other LTCD4s. Through these studies, three patents were obtained, and the benefits of these discoveries continue to be reaped in her laboratory. She has also shown that, following viral infection, CDs can release EVs, which act as intercellular communicators. These EVs, which are found in biological fluids, have also allowed her team to identify miR-155, a microRNA with a broad immunomodulatory potential, in the plasmas of HIV-1 patients. She demonstrated that the release of EVs by CDs involves the activation of DCIR. Her research program, based on these observations, therefore includes both a fundamental and translational aspect. Indeed, the development of therapeutic strategies blocking the interaction of DCIR with HIV-1, and consequently the release of EVs with immunosuppressive properties, may help to understand the early events of HIV-1 infection and lead to the design and development of new therapeutic tools. Finally, EVs are considered to play an important role in cell communication and transformation, as well as being potential biomarkers of immune activation in HIV-1 patients. In recent years, enthusiasm for these vesicles can be explained by their strong theranostic potential, and Dr. Gilbert’s laboratory differentiates itself by the biochemical methods she develops to better characterize them.

CHUL
2705, boulevard Laurier
T1-49
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46107+1 418-654-2765
caroline.gilbert@crchudeq...

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48 entries « ‹ 1 of 5 › »

Boucher J, Gilbert C, Bose S, Tessier PA

S100A9: The Unusual Suspect Connecting Viral Infection and Inflammation

Journal Article

J Immunol, 212 (10), 2024.

Abstract | Links:

Rabezanahary H, Gilbert C, Santerre K, Scarrone M, Gilbert M, Thériault M, Brousseau N, Masson JF, Pelletier JN, Boudreau D, Trottier S, Baz M

Live virus neutralizing antibodies against pre and post Omicron strains in food and retail workers in Québec, Canada

Journal Article

Heliyon, 10 (10), 2024.

Abstract | Links:

Welsh JA, Goberdhan DCI, O'Driscoll L, Buzas EI, Blenkiron C, Bussolati B, Cai H, Di Vizio D, Driedonks TAP, Erdbrügger U, Falcon-Perez JM, Fu QL, Hill AF, Lenassi M, Lim SK, Mahoney MG, Mohanty S, Möller A, Nieuwland R, Ochiya T, Sahoo S, Torrecilhas AC, Zheng L, Zijlstra A, Abuelreich S, Bagabas R, Bergese P, Bridges EM, Brucale M, Burger D, Carney RP, Cocucci E, Crescitelli R, Hanser E, Harris AL, Haughey NJ, Hendrix A, Ivanov AR, Jovanovic-Talisman T, Kruh-Garcia NA, Ku'ulei-Lyn Faustino V, Kyburz D, Lässer C, Lennon KM, Lötvall J, Maddox AL, Martens-Uzunova ES, Mizenko RR, Newman LA, Ridolfi A, Rohde E, Rojalin T, Rowland A, Saftics A, Sandau US, Saugstad JA, Shekari F, Swift S, Ter-Ovanesyan D, Tosar JP, Useckaite Z, Valle F, Varga Z, van der Pol E, van Herwijnen MJC, Wauben MHM, Wehman AM, Williams S, Zendrini A, Zimmerman AJ, , Théry C, Witwer KW

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Journal Article

J Extracell Vesicles, 13 (2), 2024.

Abstract | Links:

Attiogbe E, Larochelle S, Chaib Y, Mainzer C, Mauroux A, Bordes S, Closs B, Gilbert C, Moulin VJ

An in vitro autologous, vascularized, and immunocompetent Tissue Engineered Skin model obtained by the self-assembled approach

Journal Article

Acta Biomater, 168 , 2023.

Abstract | Links:

Bazié WW, Boucher J, Goyer B, Kania D, Traoré IT, Somé DY, Alary M, Gilbert C

HIV Replication Increases the Mitochondrial DNA Content of Plasma Extracellular Vesicles

Journal Article

Int J Mol Sci, 24 (3), 2023.

Abstract | Links:

Boucher J, Rousseau A, Boucher C, Subra C, Bazié WW, Hubert A, Bourgeault E, Benmoussa A, Goyer B, Tessier PA, Gilbert C

Immune Cells Release MicroRNA-155 Enriched Extracellular Vesicles That Promote HIV-1 Infection

Journal Article

Cells, 12 (3), 2023.

Abstract | Links:

Bazié WW, Boucher J, Traoré IT, Kania D, Somé DY, Alary M, Gilbert C

Vesicular MicroRNA as Potential Biomarkers of Viral Rebound

Journal Article

Cells, 11 (5), 2022.

Abstract | Links:

Bazié WW, Somé DY, Traoré IT, Sanon A, Konaté I, Tassembedo S, Taofiki AO, Kania D, Ouédraogo A, Vuylsteke B, Gilbert C, Meda N, Ouédraogo AS, Nagot N

Immunovirological discordance among female sex workers who start antiretroviral therapy in Burkina Faso

Journal Article

BMC Infect Dis, 22 (1), 2022.

Abstract | Links:

Bazié WW, Boucher J, Goyer B, Traoré IT, Kania D, Somé DY, Alary M, Gilbert C

Plasma vesicular miR-155 as a biomarker of immune activation in antiretroviral treated people living with HIV

Journal Article

Front Immunol, 13 , 2022.

Abstract | Links:

Chouinard FC, Davis L, Gilbert C, Bourgoin SG

Functional Role of AGAP2/PIKE-A in Fcγ Receptor-Mediated Phagocytosis

Journal Article

Cells, 12 (1), 2022.

Abstract | Links:

48 entries « ‹ 1 of 5 › »
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Active projects

  • Contribution CR au salaire d'un PSO, from 2009-07-01 to 2026-06-30
  • Étude des vésicules extracellulaires dans les fluides biologiques et compréhension des mécanismes d'incorporation des petits ARN non codants, from 2024-03-29 to 2026-03-31
  • Explorer les mécanismes des variations quotidiennes de la transcription virale résiduelle chez les personnes traités par thérapie antirétrovirale (TAR) vivant avec le VIH-1, from 2023-01-24 to 2026-12-31
  • Surveillance des réponses immunitaires au vaccin contre la COVID-19 chez les personnes vivant avec le VIH-1, from 2021-12-01 to 2025-03-31

Recently finished projects

  • Deciphering the role of DCIR in HIV-1 pathogenesis, from 2018-04-01 to 2023-03-31
  • Immunité cellulaire et séroprévalence des anticorps contre SARS-COV-2: Caractérisation de trois populations de travailleurs de l'alimentation, from 2020-11-01 to 2023-09-30
  • Synthèse d’antagonistes du DCIR pour diminuer l'infection par le VIH-1, from 2023-04-24 to 2024-04-23
Data provided by the Université Laval research projects registery