Caroline Diorio has a PhD in epidemiology (2005). Following her studies in bioinformatics and molecular oncology (2005-2008), she set up her research laboratory at Saint-Sacrement Hospital, which is part of the CHU de Québec-Laval University network, where she oversees the storage of breast cancer samples for the Tissue and Data Bank Axis of the Cancer Research Network. She holds a senior research grant and is also an associate professor and the director of epidemiology programs in Laval University’s Department of Social and Preventive Medicine. Dr Diorio is also part of the research group from the Centre des maladies du sein du CHU de Québec-Université Laval. She is the author or co-author of over 80 peer-reviewed publications in scientific journals, one third of these publications focusing on breast tissue density:  a well-established and intermediary risk factor for breast cancer.

Her most recent research projects aim at a more personalized approach to the prevention and treatment of breast cancer. On one hand, her work aims at understanding how our lifestyle can influence the onset, evolution and treatment of breast cancer, to develop personalized prevention and treatment strategies for this type of cancer. Among the different life habits studied, she is mainly interested in obesity, physical activity, and nutrition. On the other hand, the heart of her work focuses on the identification of molecular risk and prognosis markers for breast cancer that can be modulated through changes in our lifestyle habits or can be targeted by preventive and therapeutic agents. Among others, she studies inflammatory, hormonal, metabolic, genetic and epigenetic markers in the blood, and the various components of breast tissue, as well as breast lesions of varying degrees of severity. Her laboratory is funded by the Canadian Institutes of Health Research, theFondation du cancer du sein du Québec, and the Fonds de recherche du Québec-santé.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
J0-16
Québec, Québec
Canada G1S 4L8
84 entries « 1 of 9 »

Oubaddou Y, Oukabli M, Fenniche S, Elktaibi A, Elochi MR, Al Bouzidi A, Qmichou Z, Dakka N, Diorio C, Richter A, Bakri Y, Ameziane El Hassani R

BRCA1 Promoter Hypermethylation in Malignant Breast Tumors and in the Histologically Normal Adjacent Tissues to the Tumors: Exploring Its Potential as a Biomarker and Its Clinical Significance in a Translational Approach

Journal Article

Genes (Basel), 14 (9), 2023.

Abstract | Links:

Talbot D, Moodie EEM, Diorio C

Double robust estimation of optimal partially adaptive treatment strategies: An application to breast cancer treatment using hormonal therapy

Journal Article

Stat Med, 42 (2), 2023.

Abstract | Links:

Tan K, Xu J, Chen C, Vincent T, Pölönen P, Hu J, Yoshimura S, Yu W, Sussman J, Chen CH, Li E, Diorio C, Shraim R, Newman H, Uppuluri L, Li A, Chen G, Bandyopadhyay S, Wu D, Ding YY, Lim T, Hsu M, Thadi A, Ahn KJ, Wu CY, Peng J, Sun Y, Wang A, Mehta R, Frank D, Meyer L, Loh M, Raetz E, Chen Z, Wood B, Devidas M, Dunsmore K, Winter S, Chang TC, Wu G, Pounds S, Zhang N, Carroll W, Hunger S, Bernt K, Yang J, Mullighan C, Teachey D

Identification and targeting of treatment resistant progenitor populations in T-cell Acute Lymphoblastic Leukemia

Journal Article

Res Sq, 2023.

Abstract | Links:

Duchaine CS, Brisson C, Diorio C, Talbot D, Maunsell E, Carmichael PH, Giguère Y, Gilbert-Ouimet M, Trudel X, Ndjaboué R, Vézina M, Milot A, Mâsse B, Dionne CE, Laurin D

Work-Related Psychosocial Factors and Global Cognitive Function: Are Telomere Length and Low-Grade Inflammation Potential Mediators of This Association

Journal Article

Int J Environ Res Public Health, 20 (6), 2023.

Abstract | Links:

Clemenceau A, Lacouture A, Bherer J, Ouellette G, Michaud A, Audet-Walsh É, Diorio C, Durocher F

Role of Secreted Frizzled-Related Protein 1 in Early Breast Carcinogenesis and Breast Cancer Aggressiveness

Journal Article

Cancers (Basel), 15 (8), 2023.

Abstract | Links:

Burguin A, Roy J, Ouellette G, Maltais R, Bherer J, Diorio C, Poirier D, Durocher F

Aminosteroid RM-581 Decreases Cell Proliferation of All Breast Cancer Molecular Subtypes, Alone and in Combination with Breast Cancer Treatments

Journal Article

J Clin Med, 12 (13), 2023.

Abstract | Links:

Moussa H, Robitaille K, Pelletier JF, Tourigny R, Fradet Y, Lacombe L, Toren P, Lodde M, Tiguert R, Dujardin T, Caumartin Y, Duchesne T, Julien P, Savard J, Diorio C, Fradet V

Effects of Concentrated Long-Chain Omega-3 Polyunsaturated Fatty Acid Supplementation on Quality of Life after Radical Prostatectomy: A Phase II Randomized Placebo-Controlled Trial (RCT-EPA)

Journal Article

Nutrients, 15 (6), 2023.

Abstract | Links:

Dos Santos A, Ouellete G, Diorio C, Elowe S, Durocher F

Knockdown of CKAP2 Inhibits Proliferation, Migration, and Aggregate Formation in Aggressive Breast Cancer

Journal Article

Cancers (Basel), 14 (15), 2022.

Abstract | Links:

Dragic D, Chang SL, Ennour-Idrissi K, Durocher F, Severi G, Diorio C

Association between alcohol consumption and DNA methylation in blood: a systematic review of observational studies

Journal Article

Epigenomics, 14 (12), 2022.

Abstract | Links:

Djade CD, Diorio C, Laurin D, Dionne CE

An exploratory identification of biological markers of chronic musculoskeletal pain in the low back, neck, and shoulders

Journal Article

PLoS One, 17 (4), 2022.

Abstract | Links:

84 entries « 1 of 9 »
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Active projects

  • Axe banque de tissus et de données BTD, from 2011-04-01 to 2024-03-31
  • Banque de tissu Sein-Ovaire, from 2000-01-01 to 2024-03-31
  • Breast adipocyte hypertrophy: a novel biomarker to predict breast cancer survival, from 2022-01-01 to 2024-12-31
  • Deciphering breast cancer HER2-negativity with regard to HER2-targeted therapy, from 2016-07-01 to 2025-03-31
  • Deciphering the role of FGD5 during breast cancer progression, from 2021-05-01 to 2024-03-31
  • Design for Better Health: User-Centred Design and Evaluation of Interactive Media for Health Education, Communication and Decision-Making, from 2016-07-01 to 2025-03-31
  • Effect of environmental contaminants and methylome of breast adipose tissue on aromatase inhibitor efficacy in breast cancer, from 2016-07-01 to 2024-09-30
  • L’AIMZ-938, un nouveau promédicament anticancéreux pour le traitement des cancers du sein humain réfractaires aux traitements actuels et exprimant le cytochrome P450 1A1, from 2021-10-01 to 2026-09-30
  • Management of sleeve gastrectomy failure using single-anastomosis metabolic surgery, from 2021-10-01 to 2026-09-30
  • Omega-3 fatty acids in the prevention of breast cancer: role of obesity-related markers in breast tissues, from 2018-10-01 to 2026-09-30
  • The effect of cannabinoid receptors on breast cancer survival, from 2022-09-01 to 2024-08-31
  • Tumor biobanking was supported...Fondation du cancer du sein du Québec and the Banque de tissus...of the Réseau...(RRCancer)...by the Oncopole, the FRQS cancer hub,...Ministère de l'Économie, de l'Innovation et de l'Énergie du Québec., from 2023-04-01 to 2024-03-31
  • Vers des trajectoires de soins en cancer du sein personnalisées en fonction du risque et des besoins des patientes: une étude de faisabilité et d'acceptabilité, from 2023-04-01 to 2025-03-31

Recently finished projects

  • TBC1D9: therapeutic target of the aggressiveness of triple negative breast cancer, from 2023-03-01 to 2024-02-29
  • What are my options? A feasibility study of a personalized primary prevention strategy for women and men at high risk of breast and prostate cancer, from 2022-01-15 to 2024-01-14
Data provided by the Université Laval research projects registery