Caroline Diorio has a PhD in epidemiology (2005). Following her studies in bioinformatics and molecular oncology (2005-2008), she set up her research laboratory at Saint-Sacrement Hospital, which is part of the CHU de Québec-Laval University network, where she oversees the storage of breast cancer samples for the Tissue and Data Bank Axis of the Cancer Research Network. She holds a senior research grant and is also an associate professor and the director of epidemiology programs in Laval University’s Department of Social and Preventive Medicine. Dr Diorio is also part of the research group from the Centre des maladies du sein du CHU de Québec-Université Laval. She is the author or co-author of over 80 peer-reviewed publications in scientific journals, one third of these publications focusing on breast tissue density:  a well-established and intermediary risk factor for breast cancer.

Her most recent research projects aim at a more personalized approach to the prevention and treatment of breast cancer. On one hand, her work aims at understanding how our lifestyle can influence the onset, evolution and treatment of breast cancer, to develop personalized prevention and treatment strategies for this type of cancer. Among the different life habits studied, she is mainly interested in obesity, physical activity, and nutrition. On the other hand, the heart of her work focuses on the identification of molecular risk and prognosis markers for breast cancer that can be modulated through changes in our lifestyle habits or can be targeted by preventive and therapeutic agents. Among others, she studies inflammatory, hormonal, metabolic, genetic and epigenetic markers in the blood, and the various components of breast tissue, as well as breast lesions of varying degrees of severity. Her laboratory is funded by the Canadian Institutes of Health Research, theFondation du cancer du sein du Québec, and the Fonds de recherche du Québec-santé.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
J0-16
Québec, Québec
Canada G1S 4L8
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Djade CD, Diorio C, Laurin D, Dionne CE

An exploratory identification of biological markers of chronic musculoskeletal pain in the low back, neck, and shoulders

Journal Article

PLoS One, 17 (4), 2022.

Abstract | Links:

Devine KJ, Diorio C, Richman SA, Henderson AA, Oranges K, Armideo E, Kolb MS, Freedman JL, Aplenc R, Fisher MJ, Minturn JE, Olson T, Bagatell R, Barakat L, Croy C, Mauro J, Vitlip L, Acord MR, Mattei P, Johnson VK, Devine CM, Pasquariello C, Reilly AF

Guideline for Children With Cancer Receiving General Anesthesia for Procedures and Imaging

Journal Article

J Pediatr Hematol Oncol, 44 (4), 2022.

Abstract | Links:

Morin-Buote J, Ennour-Idrissi K, Poirier É, Lemieux J, Furrer D, Burguin A, Durocher F, Diorio C

Association of Breast Tumour Expression of Cannabinoid Receptors CBR1 and CBR2 with Prognostic Factors and Survival in Breast Cancer Patients

Journal Article

J Pers Med, 11 (9), 2021.

Abstract | Links:

Gagnet S, Diorio C, Provencher L, Mbuya-Bienge C, Lapointe J, Morin C, Lemieux J, Nabi H

Identifying Clinicopathological Factors Associated with Oncotype DX 21-Gene Recurrence Score: A Real-World Retrospective Cohort Study of Breast Cancer Patients in Quebec City, Canada

Journal Article

J Pers Med, 11 (9), 2021.

Abstract | Links:

Duchaine CS, Brisson C, Talbot D, Gilbert-Ouimet M, Trudel X, Vézina M, Milot A, Diorio C, Ndjaboué R, Giguère Y, Mâsse B, Dionne CE, Maunsell E, Laurin D

Psychosocial stressors at work and inflammatory biomarkers: PROspective Quebec Study on Work and Health

Journal Article

Psychoneuroendocrinology, 133 , 2021.

Abstract | Links:

Duchaine CS, Brisson C, Talbot D, Gilbert-Ouimet M, Trudel X, Vézina M, Milot A, Diorio C, Ndjaboué R, Giguère Y, Mâsse B, Dionne CE, Maunsell E, Laurin D

Cumulative exposure to psychosocial stressors at work and global cognitive function: the PROspective Quebec Study on Work and Health

Journal Article

Occup Environ Med, 78 (12), 2021.

Abstract | Links:

Kothari C, Clemenceau A, Ouellette G, Ennour-Idrissi K, Michaud A, C-Gaudreault R, Diorio C, Durocher F

TBC1D9: An Important Modulator of Tumorigenesis in Breast Cancer

Journal Article

Cancers (Basel), 13 (14), 2021.

Abstract | Links:

Chang SL, Tchernof A, Durocher F, Diorio C

Associations of Biomarkers of Inflammation and Breast Cancer in the Breast Adipose Tissue of Women with Combined Measures of Adiposity

Journal Article

J Obes, 2021 , 2021.

Abstract | Links:

Burguin A, Diorio C, Durocher F

Breast Cancer Treatments: Updates and New Challenges

Journal Article

J Pers Med, 11 (8), 2021.

Abstract | Links:

Kothari C, Clemenceau A, Ouellette G, Ennour-Idrissi K, Michaud A, Diorio C, Durocher F

Is Carboxypeptidase B1 a Prognostic Marker for Ductal Carcinoma In Situ?

Journal Article

Cancers (Basel), 13 (7), 2021.

Abstract | Links:

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Active projects

  • Axe banque de tissus et de données BTD, from 2011-04-01 to 2023-03-31
  • Banque de tissu Sein-Ovaire, from 2000-01-01 to 2023-03-31
  • Breast adipocyte hypertrophy: a novel biomarker to predict breast cancer survival, from 2022-01-01 to 2023-03-31
  • Deciphering the role of FGD5 during breast cancer progression, from 2021-05-01 to 2023-04-30
  • Effect of environmental contaminants and methylome of breast adipose tissue on aromatase inhibitor efficacy in breast cancer, from 2016-07-01 to 2024-09-30
  • L’AIMZ-938, un nouveau promédicament anticancéreux pour le traitement des cancers du sein humain réfractaires aux traitements actuels et exprimant le cytochrome P450 1A1, from 2021-10-01 to 2026-09-30
  • Management of sleeve gastrectomy failure using single-anastomosis metabolic surgery, from 2021-10-01 to 2026-09-30
  • Omega-3 fatty acids in the prevention of breast cancer: role of obesity-related markers in breast tissues, from 2018-10-01 to 2026-09-30
  • What are my options? A feasibility study of a personalized primary prevention strategy for women and men at high risk of breast and prostate cancer, from 2022-01-15 to 2023-01-14

Recently finished projects

  • Bourse Concert pour la vie , from 2020-11-13 to 2021-11-12
  • Deciphering breast cancer HER2-negativity with regard to HER2-targeted therapy, from 2016-07-01 to 2021-06-30
  • Design for Better Health: User-Centred Design and Evaluation of Interactive Media for Health Education, Communication and Decision-Making, from 2016-07-01 to 2021-06-30
  • Une approche personnalisée pour la prévention et le traitement du cancer du sein, from 2017-08-01 to 2020-07-31
  • Utilisation de l'intelligence artificielle (IA) afin de prédire les résultats de biopsies faites pour les mammographies anormales avec comme but ultime de réduire le nombre de biopsies , from 2019-12-09 to 2021-12-08
Data provided by the Université Laval research projects registery