Dr. Barbara Papadopoulou, B.Pharm., M.Sc., Ph.D., is a Professor in the Department of Microbiology-Infectious Disease and Immunology of the Laval University School of Medicine and the Director of the Axis of Infectious Diseases and Immunity of the CHU de Quebec Research Center-Laval University, since 2010. Her areas of expertise are parasitic diseases, regulation of gene expression, microbial pathogenesis, genomics, and vaccinology. Over the years, her laboratory has made remarkable discoveries on the molecular mechanisms controlling the intracellular development of the protozoan parasite Leishmania and on post-transcriptional regulation by novel classes of 3’UTR elements and RNA binding factors that have significantly advanced knowledge in this area. The fascinating concept of coordinated gene regulation by retroposons has revolutionized the landscape of gene expression control in this parasite. Her laboratory has also been a pioneer in the use of reverse genetics and genomics in Leishmania. She has also contributed to original work on the development of promising vaccine strategies against Leishmania infections. Her sustained efforts on vaccine development have led to patents and innovative live vaccine-based strategies that are currently being evaluated in relevant disease models in endemic countries. Dr. Papadopoulou is an internationally recognized leader in the field of Leishmania. She currently holds some very influential roles in international research networks (Leishmania Genome Network, TriTrypDB, The European Cooperation in the Field of Scientific and Technical Research COST B22) and in advisory expert committees (WorldLeish, World Health Organization) and she has established numerous collaborations, internationally. She has been actively involved, as member of the organizing scientific or local committees, in the organization of more than 8 international congresses on leishmaniasis and other parasitic diseases, and has also organized more than 15 symposia in this field.

Dr. Papadopoulou is the author of over 135 scientific publications and of several reviews and book chapters. She has received several prestigious national and international awards and distinctions for excellence in research, including the Burroughs Wellcome Fund Award in Molecular Parasitology for her outstanding contributions to the field of Leishmania research, and the nomination as Fellow of the Canadian Academy of Health Sciences, in 2013. Her leadership role as a woman in biomedical sciences has also been highlighted on several occasions (YWCA Women of Distinction Award Winner 2012, Science and Technology, 50 Successful Women from the Quebec City Region of Chaudière-Appalaches, ’22 Quebecers to watch’ by L’Actualité magazine, etc.). Dr. Papadopoulou is a member of several international consortia, as well as national (CIHR) and international (Burroughs Wellcome Fund Pathogenesis of Infectious Disease Program, Faculty of 1000 Biology, National Council for Scientific and Technological Development/Brazil, Hellenic Quality Assurance Agency for higher education, etc.) peer review and advisory committees. She is also an elected Faculty member of Greek Universities (APELLA). Until recently, she was until a member and Vice-Chairman of the Board of Directors of the Fonds de Recherche du Québec-Santé (FRQS) and the Board of Directors of the Canadian Academy of Health Sciences.

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da Silva W, Ribeiro IC, Agripino JM, da Silva VHF, de Souza LÂ, Oliveira TA, Bressan GC, Vasconcellos RS, Dumas C, Pelletier J, Sévigny J, Papadopoulou B, Fietto JLR

Leishmania infantum NTPDase1 and NTPDase2 play an important role in infection and nitric oxide production in macrophages

Journal Article

Acta Trop, 237 , 2022.

Abstract | Links:

Assis LA, Santos Filho MVC, da Cruz Silva JR, Bezerra MJR, de Aquino IRPUC, Merlo KC, Holetz FB, Probst CM, Rezende AM, Papadopoulou B, da Costa Lima TDC, de Melo Neto OP

Identification of novel proteins and mRNAs differentially bound to the Leishmania Poly(A) Binding Proteins reveals a direct association between PABP1, the RNA-binding protein RBP23 and mRNAs encoding ribosomal proteins

Journal Article

PLoS Negl Trop Dis, 15 (10), 2021.

Abstract | Links:

Padmanabhan PK, Ferreira GR, Zghidi-Abouzid O, Oliveira C, Dumas C, Mariz FC, Papadopoulou B

Genetic depletion of the RNA helicase DDX3 leads to impaired elongation of translating ribosomes triggering co-translational quality control of newly synthesized polypeptides

Journal Article

Nucleic Acids Res, 49 (16), 2021.

Abstract | Links:

Bhattacharya A, Bigot S, Padmanabhan PK, Mukherjee A, Coelho A, Leprohon P, Papadopoulou B, Ouellette M

New insights in the mode of action of anti-leishmanial drugs by using chemical mutagenesis screens coupled to next-generation sequencing

Journal Article

Microb Cell, 7 (2), 2020.

Abstract | Links:

Aguiar BG, Dumas C, Maaroufi H, Padmanabhan PK, Papadopoulou B

The AAA + ATPase valosin-containing protein (VCP)/p97/Cdc48 interaction network in Leishmania

Journal Article

Sci Rep, 10 (1), 2020.

Abstract | Links:

Azizi H, Papadopoulou B

In Vivo Tethering System to Isolate RNA-Binding Proteins Regulating mRNA Decay in Leishmania

Journal Article

Methods Mol Biol, 2116 , 2020.

Abstract | Links:

Bhattacharya A, Leprohon P, Bigot S, Padmanabhan PK, Mukherjee A, Roy G, Gingras H, Mestdagh A, Papadopoulou B, Ouellette M

Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania

Journal Article

Nat Commun, 10 (1), 2019.

Abstract | Links:

de Melo Neto OP, da Costa Lima TDC, Merlo KC, Romao TP, Rocha PO, Assis LA, Nascimento LM, Xavier CC, Rezende AM, Reis CRS, Papadopoulou B

Phosphorylation and interactions associated with the control of the Leishmania Poly-A Binding Protein 1 (PABP1) function during translation initiation

Journal Article

RNA Biol, 15 (6), 2018.

Abstract | Links:

Guedes Aguiar B, Padmanabhan PK, Dumas C, Papadopoulou B

Valosin-containing protein VCP/p97 is essential for the intracellular development of Leishmania and its survival under heat stress

Journal Article

Cell Microbiol, 20 (10), 2018.

Abstract | Links:

Ponte-Sucre A, Gamarro F, Dujardin JC, Barrett MP, López-Vélez R, García-Hernández R, Pountain AW, Mwenechanya R, Papadopoulou B

Drug resistance and treatment failure in leishmaniasis: A 21st century challenge

Journal Article

PLoS Negl Trop Dis, 11 (12), 2017.

Abstract | Links:

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Active projects

  • Deciphering new concepts of posttranscriptional regulation central to the biology of the human intracellular pathogen Leishmania, from 2022-04-01 to 2027-03-31
  • Role of the RNA-binding protein RBP25 in translation regulation in Leishmania, from 2022-02-21 to 2023-09-30

Recently finished projects

  • Centre de recherche sur les interactions hôte-parasite (CRIHP), from 2015-04-01 to 2021-03-31
  • Deciphering new concepts of posttranscriptional regulation central to the biology of the human intracellular pathogen Leishmania, from 2021-10-01 to 2022-09-30
  • Post-transcriptional regulatory networks coordinating developmental gene expression in the human pathogen Leishmania, from 2016-07-01 to 2021-06-30
  • Prevention of the immunopathology induced by SARS-CoV-2, from 2021-06-01 to 2022-05-31
Data provided by the Université Laval research projects registery