Following a Master in physiology, cellular and molecular biology at the University of Poitiers in France, Dr. ElAli earned a Doctorate (Dr. rer nat) in cellular and molecular neuroscience from the University of Duisburg-Essen in Germany, jointly with the University of Zurich in Switzerland. Afterwards, he completed a first postdoctoral training in vascular neurology in cerebrovascular diseases at the Research center of the University Hospital Center of Essen in Germany. He then completed a second postdoctoral training in neuroimmunology in cerebrovascular and neurodegenerative diseases at the Research Center of CHU de Québec – Laval University. Dr. ElAli has joined the Department of Psychiatry and Neuroscience at Laval University in July 2015. He is the recipient of a career award from the Fonds de recherche du Québec-Santé (FRQS), and has previously received several career awards and prizes of excellence, mainly from the German Research Foundation ‘Deutsche Forschungsgemeinschaft (DFG)’, and the ‘Dr Werner Jackstaedt-Stiftung’ Foundation in Germany.

Cerebrovascular diseases mainly include strokes, which constitute a major cause of death and disability in Canadian adults. The great majority of cases are ischemic, caused by the occlusion of a cerebral artery by a blood clot. Beyond thrombolysis that aims at restoring the cerebral blood circulation by dissolving the clot, no effective disease-modifying treatment exists. Recent studies, including those performed by Dr. ElAli, have outlined the presence of a structural and functional remodelling process of the network of cells that constitutes the neurovascular unit following a stroke. This network includes endothelial cells, pericytes, astrocytes, microglia, and neurons that work together to enable the proper functioning of the brain. Emerging evidence suggests that the remodelling process decisively influences the regeneration of the injured tissue, thus providing new perspectives for the development of innovative interventions in stroke therapies.

Dr. ElAli’s research program aims to explore the cellular and molecular mechanisms involved in the remodelling of the neurovascular unit following a stroke. He is particularly interested in endothelial cells and pericytes as these two cell types constitute the core of the neurovascular unit. The endothelial cells form the blood-brain barrier that plays an essential role in maintaining the brain homeostasis. The pericytes play a crucial role in stabilization of the vascular system, and act as pluripotent cells capable to be differentiated into vascular, glial and neuronal cells. Dr. ElAli’s laboratory strategy consists of targeting specialized molecular mechanisms in the endothelial cells in order to restore the blood-brain barrier, and the function of pericytes in order to stabilize the vascular system and promote the regenerative potential of these cells. The ultimate goal of this strategy is to re-establish the integrity of the neurovascular unit as a way of regenerating the injured tissue.

CHUL
2705, boulevard Laurier
T2-39
Québec, Québec
Canada G1V 4G2
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Manrique-Castano D, ElAli A

Unbiased quantification of the spatial distribution of murine cells using point pattern analysis

Journal Article

STAR Protoc, 5 (2), 2024.

Abstract | Links:

Lecordier S, Menet R, Allain AS, ElAli A

Non-classical monocytes promote neurovascular repair in cerebral small vessel disease associated with microinfarctions via CX3CR1

Journal Article

J Cereb Blood Flow Metab, 43 (11), 2023.

Abstract | Links:

ElAli A

Endothelial caveolin at the crossroad of thrombo-inflammation coupling

Journal Article

EBioMedicine, 86 , 2022.

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Al-Onaizi M, Al-Sarraf A, Braysh K, Kazem F, Al-Hussaini H, Rao M, Kilarkaje N, ElAli A

Impaired spatial navigation and age-dependent hippocampal synaptic dysfunction are associated with chronic inflammatory response in db/db mice

Journal Article

Eur J Neurosci, 56 (11), 2022.

Abstract | Links:

Al-Onaizi MA, Thériault P, Lecordier S, Prefontaine P, Rivest S, ElAli A

Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression

Journal Article

Brain Behav Immun, 99 , 2022.

Abstract | Links:

Lecordier S, Manrique-Castano D, El Moghrabi Y, ElAli A

Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors

Journal Article

Front Aging Neurosci, 13 , 2021.

Abstract | Links:

Lecordier S, Pons V, Rivest S, ElAli A

Multifocal Cerebral Microinfarcts Modulate Early Alzheimer's Disease Pathology in a Sex-Dependent Manner

Journal Article

Front Immunol, 12 , 2021.

Abstract | Links:

Manrique-Castano D, ElAli A

Neurovascular reactivity in tissue scarring following cerebral ischemia

Book Chapter

Pluta R (Ed.): Cerebral Ischemia, pp. 111-129, Brisbane, Exon Publications, 2021, ISBN: 9780645001792.

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Khaddaj-Mallat R, Aldib N, Bernard M, Paquette AS, Ferreira A, Lecordier S, Saghatelyan A, Flamand L, ElAli A

SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein

Journal Article

Neurobiol Dis, 161 , 2021.

Abstract | Links:

Al-Onaizi M, Al-Khalifah A, Qasem D, ElAli A

Role of Microglia in Modulating Adult Neurogenesis in Health and Neurodegeneration

Journal Article

Int J Mol Sci, 21 (18), 2020.

Abstract | Links:

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Active projects

  • Canada Research Chair in molecular and cellular neurovascular interactions, from 2020-07-01 to 2025-06-30
  • Elucidate the role of KLF4 in regulating mural cell contribution to tissue repair after stroke, from 2023-07-01 to 2026-06-30
  • Investigate the mechanisms regulating the fibrotic reaction mediated by perivascular cells in cerebrovascular disorders, from 2023-04-01 to 2028-03-31
  • Mechanisms regulating contribution of pericytes to brain repair after stroke, from 2020-04-01 to 2025-03-31

Recently finished projects

  • Bourse de soutien aux nouveaux détenteurs de Chaire de recherche du Canada, from 2020-07-01 to 2022-06-30
  • Role of canonical Wnt pathway in regulating the structural and functional integrity of the blood-brain barrier in the normal adult brain, from 2017-04-01 to 2024-03-31
Data provided by the Université Laval research projects registery