Arnaud Droit is an associate professor with the Department of Molecular Medicine at Laval University’s School of Medicine, and a researcher at the CHU de Québec–Laval University Research Centre, where he heads the bioinformatics and proteomics platform. He is also a member of the executive directorate of Laval University’s Big Data Research Centre (CRDM). Arnaud Droit studied biochemistry and bioinformatics at Université Toulouse III – Paul Sabatier, in France, and holds a PhD from Laval University.

Dr. Droit’s research program aims at developing new approaches and methods in computational genomics to analyze the genomic and proteomic data collected, effectively and thoroughly, using next-generation technology. His work is at the crossroads of biology and computer science.

Since 2016, he holds the L’Oréal Chair in Research and Innovation in Digital Biology, the first research chair in digital biology, which constitutes a center of excellence for the development of multi-omic big data technologies (which include the different fields of biology ending with the suffix « omic »: genomic, epigenomic, proteomic, metagenomic, etc.) and analyses.

Dr. Droit oversees a number of large-scale projects that address the challenges of managing massive data and extracting actionable knowledge for the life science community. One of his projects aims to aggregate many biological data sources, link them together, discover new relationships, and make them available on the Internet via dynamic visualization interfaces. He is also involved in the development of machine learning tools dedicated to clinical research and multi-omics data, which can also be extended to other areas. Other projects also cover temporal multi-omic data analysis, which requires the development of new approaches, and the identification of genes interacting together through the creation of coexpression networks.

Finally, Dr. Droit has established many international collaborations that allow him to cover a variety of fields in biology research, including oncology, immunology, and skin diseases.

CHUL
2705, boulevard Laurier
R-4720
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46411
+1 418-654-2298
Arnaud.Droit@crchudequebe...

Latest news

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Bui TA, Rosenfelt CS, Whitlock KH, Leclercq M, Weber S, Droit A, Wiebe SA, Pei J, Bolduc FV

Long-term Memory Testing in Children With Typical Development and Neurodevelopmental Disorders: Remote Web-based Image Task Feasibility Study

Journal Article

JMIR Pediatr Parent, 6 , 2023.

Abstract | Links:

Mohammadi F, Green M, Tolsdorf E, Greffard K, Leclercq M, Bilodeau JF, Droit A, Foster J, Bertrand N, Rudkowska I

Industrial and Ruminant Trans-Fatty Acids-Enriched Diets Differentially Modulate the Microbiome and Fecal Metabolites in C57BL/6 Mice

Journal Article

Nutrients, 15 (6), 2023.

Abstract | Links:

Poisson W, Prunier J, Carrier A, Gilbert I, Mastromonaco G, Albert V, Taillon J, Bourret V, Droit A, Côté SD, Robert C

Chromosome-level assembly of the Rangifer tarandus genome and validation of cervid and bovid evolution insights

Journal Article

BMC Genomics, 24 (1), 2023.

Abstract | Links:

Chiu CC, Pelletier G, Stival Sena J, Roux-Dalvai F, Prunier J, Droit A, Séguin A

Integrative analysis of green ash phloem transcripts and proteins during an emerald ash borer infestation

Journal Article

BMC Plant Biol, 23 (1), 2023.

Abstract | Links:

Fakih Z, Plourde MB, Nkouankou CET, Fourcassié V, Bourassa S, Droit A, Germain H

Specific alterations in riboproteomes composition of isonicotinic acid treated arabidopsis seedlings

Journal Article

Plant Mol Biol, 111 (4-5), 2023.

Abstract | Links:

Chan D, Ly L, Rebolledo EMD, Martel J, Landry M, Scott-Boyer MP, Droit A, Trasler JM

Transgenerational impact of grand-paternal lifetime exposures to both folic acid deficiency and supplementation on genome-wide DNA methylation in male germ cells

Journal Article

Andrology, 2023.

Abstract | Links:

Alves MBR, Girardet L, Augière C, Moon KH, Lavoie-Ouellet C, Bernet A, Soulet D, Calvo E, Teves ME, Beauparlant CJ, Droit A, Bastien A, Robert C, Bok J, Hinton BT, Belleannée C

Hedgehog signaling regulates Wolffian duct development through the primary cilium†

Journal Article

Biol Reprod, 108 (2), 2023.

Abstract | Links:

Furrer D, Dragic D, Chang SL, Fournier F, Droit A, Jacob S, Diorio C

Association between genome-wide epigenetic and genetic alterations in breast cancer tissue and response to HER2-targeted therapies in HER2-positive breast cancer patients: new findings and a systematic review

Journal Article

Cancer Drug Resist, 5 (4), 2022.

Abstract | Links:

Raufaste-Cazavieille V, Santiago R, Droit A

Multi-omics analysis: Paving the path toward achieving precision medicine in cancer treatment and immuno-oncology

Journal Article

Front Mol Biosci, 9 , 2022.

Abstract | Links:

Carrier A, Prunier J, Poisson W, Trottier-Lavoie M, Gilbert I, Cavedon M, Pokharel K, Kantanen J, Musiani M, Côté SD, Albert V, Taillon J, Bourret V, Droit A, Robert C

Design and validation of a 63K genome-wide SNP-genotyping platform for caribou/reindeer (Rangifer tarandus)

Journal Article

BMC Genomics, 23 (1), 2022.

Abstract | Links:

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Active projects

  • Artificial intelligence tool for fast and accurate identification of mastitis pathogenic and spoilage microorganisms in milk, from 2022-04-01 to 2024-03-31
  • Caractérisation de la structure 3D et de la coloration des perles chez Pinctada sp. par analyse d’image., from 2021-01-01 to 2023-12-31
  • Caribou Genomics : a National Non-Invasive Monitoring Approach for an Iconic and Model Species-at-Risk, from 2020-10-01 to 2023-09-30
  • Chaire de recherche et d'innovation l'Oréal en biologie numérique, from 2016-05-16 to 2026-05-15
  • Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada, from 2021-06-01 to 2024-05-31
  • Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in chronic neurodegenerative diseases, from 2020-03-01 to 2025-03-31
  • Dévelooppement d'algorithmes d'interprétation de modèles d'apprentissage profond pour la découverte de biomarqueurs, from 2020-04-01 to 2023-12-31
  • Development of high accuracy models for MICROB-AI, a new generation of diagnosis test for UTI, from 2021-07-01 to 2023-06-30
  • Développement de nouvelles approches immunothérapeutiques dirigées contre des néoantigènes dérivés de gènes de fusion pour le traitement de la leucémie aiguë pédiatrique, from 2022-06-15 to 2025-06-14
  • Développement de nouvelles connaissances sur les cibles biologiques du 2-hexénal en vue de son utilisation comme bioherbicide, from 2023-03-15 to 2026-03-14
  • Développement de solutions diagnostiques pour les troubles neurodéveloppementaux causés par un dysfonctionnement du système Ubiquitine-Protéasome, from 2023-02-01 to 2026-01-31
  • Développement de stratégies d'apprentissage automatisées pour déterminer les phénogroupes, la progression et les issues cliniques de la sténose valvulaire aortique, from 2022-12-06 to 2024-09-30
  • Identifying novel molecular insights from life science massive data, from 2018-04-01 to 2024-03-31
  • Influence de l’environnement leucémique dans le développement d’évènements thrombotiques chez les enfants atteints de leucémie lymphoblastique aigue traités dans l’essai thérapeutique international prospectif DFCI 16-001, from 2023-02-21 to 2024-03-31
  • Influence of hyperglycemia on the host-microbiome interactions during subgingival microbiome dysbiosis, from 2020-12-11 to 2023-06-10
  • Leveraging the impact of diversity in neurodevelopmental disability by integrating machine learning in personalized interventions, from 2020-02-01 to 2024-03-31
  • L’AIMZ-938, un nouveau promédicament anticancéreux pour le traitement des cancers du sein humain réfractaires aux traitements actuels et exprimant le cytochrome P450 1A1, from 2021-10-01 to 2026-09-30
  • Nouvelle approche intégrative de génomique du microbiome pour des luzernières plus durables, from 2022-07-01 to 2024-06-30
  • Nouvelle approche moléculaire pour la détection simultanée des virus pathogènes aux framboisiers et aux fraisiers, from 2019-08-01 to 2023-08-31
  • Observatoire international sur les impacts sociétaux de l'intelligence artificielle et du numérique, from 2018-04-01 to 2024-03-31
  • Outil d'intelligence artificielle pour l'identification rapide et précise des bactéries pathogènes chez les animaux et/ou chez l'humain dans le lait et les produits laitiers, from 2021-04-01 to 2024-03-31
  • Outil d'intelligence artificielle pour l'identification rapide et précise des micro-organismes dans le lait, from 2022-03-24 to 2025-04-30
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II), from 2017-11-01 to 2024-03-31
  • Personalized ultra-fast detection and treatment of resistant microbial infections, from 2023-03-31 to 2025-03-30
  • Role of megakaryocytes in Systemic Lupus Erythematosus, from 2023-04-01 to 2028-03-31
  • Therapeutic approach to preserve Tfh cells and improve B cell immunity in simian immunodeficiency virus infected rhesus macaques, from 2021-04-01 to 2026-03-31
  • Une infrastructure IA multi-usagers clé en main pour gérer le cycle de vie complet des données en santé, from 2021-04-01 to 2023-09-01
  • Utilisation du séquençage à haut débit pour l’identification d’organismes pathogènes des plantes, from 2019-08-01 to 2023-08-31

Recently finished projects

  • Calcul Québec, from 2015-04-01 to 2023-03-31
  • Cellular mechanisms regulating the pathogenesis of secondary progressive CNS autoimmunity, from 2018-10-01 to 2023-03-31
  • Computer-Aided Sperm Analysis (CASA) of sperm motility and hyperactivation, from 2021-04-01 to 2022-03-31
  • Development of Comprehensive Cytogenomics and Molecular Genetics Testing Using ans Exome and Low-Pass Whole Genome Sequencing Combined Approach, from 2019-01-01 to 2021-12-31
  • Développement d'approches par apprentissage actif et en budget contraint à partir de données de cardiologie, from 2021-08-01 to 2021-10-29
  • Father's lasting influence: Molecular foundations of intergenerational transmission of the paternal environment, from 2014-11-01 to 2023-03-31
  • Impact of the sperm epigenome on the progeny outcome born by assisted reproductive technology, from 2016-07-01 to 2021-12-31
  • Live viral spectroscopy for rapid Covid-19 detection applied directly to clinical biofluids without sample processing, from 2020-08-01 to 2021-07-31
  • Predict to prevent: Advanced proteomics profiling for precision medicine, from 2021-03-23 to 2022-09-30
  • Prevention of the immunopathology induced by SARS-CoV-2, from 2021-06-01 to 2022-05-31
  • Use of genomics to manage and protect caribou populations, from 2018-04-01 to 2022-12-31
Data provided by the Université Laval research projects registery