Arnaud Droit is an associate professor with the Department of Molecular Medicine at Laval University’s School of Medicine, and a researcher at the CHU de Québec–Laval University Research Centre, where he heads the bioinformatics and proteomics platform. He is also a member of the executive directorate of Laval University’s Big Data Research Centre (CRDM). Arnaud Droit studied biochemistry and bioinformatics at Université Toulouse III – Paul Sabatier, in France, and holds a PhD from Laval University.

Dr. Droit’s research program aims at developing new approaches and methods in computational genomics to analyze the genomic and proteomic data collected, effectively and thoroughly, using next-generation technology. His work is at the crossroads of biology and computer science.

Since 2016, he holds the L’Oréal Chair in Research and Innovation in Digital Biology, the first research chair in digital biology, which constitutes a center of excellence for the development of multi-omic big data technologies (which include the different fields of biology ending with the suffix « omic »: genomic, epigenomic, proteomic, metagenomic, etc.) and analyses.

Dr. Droit oversees a number of large-scale projects that address the challenges of managing massive data and extracting actionable knowledge for the life science community. One of his projects aims to aggregate many biological data sources, link them together, discover new relationships, and make them available on the Internet via dynamic visualization interfaces. He is also involved in the development of machine learning tools dedicated to clinical research and multi-omics data, which can also be extended to other areas. Other projects also cover temporal multi-omic data analysis, which requires the development of new approaches, and the identification of genes interacting together through the creation of coexpression networks.

Finally, Dr. Droit has established many international collaborations that allow him to cover a variety of fields in biology research, including oncology, immunology, and skin diseases.

CHUL
2705, boulevard Laurier
R-4720
Québec, Québec
Canada G1V 4G2
182 entries « 1 of 19 »

Bergum OET, Singleton AH, Røst LM, Bodein A, Scott-Boyer MP, Rye MB, Droit A, Bruheim P, Otterlei M

SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated

Journal Article

Front Microbiol, 15 , 2024.

Abstract | Links:

Mahdavi A, Leclercq M, Droit A, Rudkowska I, Lebel M

Predictive model for vitamin C levels in hyperinsulinemic individuals based on age, sex, waist circumference, low-density lipoprotein, and immune-associated serum proteins

Journal Article

J Nutr Biochem, 125 , 2024.

Abstract | Links:

Carrier M, Hui CW, Watters V, Šimončičová E, Picard K, González Ibáñez F, Vernoux N, Droit A, Desjardins M, Tremblay MÈ

Behavioral as well as hippocampal transcriptomic and microglial responses differ across sexes in adult mouse offspring exposed to a dual genetic and environmental challenge

Journal Article

Brain Behav Immun, 116 , 2024.

Abstract | Links:

Rouleau M, Villeneuve L, Allain EP, McCabe-Leroux J, Tremblay S, Nguyen Van Long F, Uchil A, Joly-Beauparlant C, Droit A, Guillemette C

Non-canonical transcriptional regulation of the poor prognostic factor UGT2B17 in chronic lymphocytic leukemic and normal B cells

Journal Article

BMC Cancer, 24 (1), 2024.

Abstract | Links:

Marroquín-Rivera A, Zhao C, Pessoni AM, Bherer J, Mansouri S, Droit A, Labonté B

Immune-related transcriptomic and epigenetic reconfiguration in BV2 cells after lipopolysaccharide exposure: an in vitro omics integrative study

Journal Article

Inflamm Res, 73 (2), 2024.

Abstract | Links:

Ganouna-Cohen G, Marcouiller F, Blachot-Minassian B, Demarest M, Beauparlant CJ, Droit A, Belaidi E, Bairam A, Joseph V

Loss of testosterone induces postprandial insulin resistance and increases the expression of the hepatic antioxidant flavin-containing monooxygenases in mice exposed to intermittent hypoxia

Journal Article

Acta Physiol (Oxf), 240 (3), 2024.

Abstract | Links:

Allaeys I, Lemaire G, Leclercq M, Lacasse E, Fleury M, Dubuc I, Gudimard L, Puhm F, Tilburg J, Stone AP, Machlus KR, Droit A, Flamand L, Boilard E

SARS-CoV-2 infection modifies the transcriptome of the megakaryocytes in the bone marrow

Journal Article

Blood Adv, 2024.

Abstract | Links:

Küry S, Stanton JE, van Woerden G, Hsieh TC, Rosenfelt C, Scott-Boyer MP, Most V, Wang T, Papendorf JJ, de Konink C, Deb W, Vignard V, Studencka-Turski M, Besnard T, Hajdukowicz AM, Thiel F, Möller S, Florenceau L, Cuinat S, Marsac S, Wentzensen I, Tuttle A, Forster C, Striesow J, Golnik R, Ortiz D, Jenkins L, Rosenfeld JA, Ziegler A, Houdayer C, Bonneau D, Torti E, Begtrup A, Monaghan KG, Mullegama SV, Volker-Touw CMLN, van Gassen KLI, Oegema R, de Pagter M, Steindl K, Rauch A, Ivanovski I, McDonald K, Boothe E, Dauber A, Baker J, Fabie NAV, Bernier RA, Turner TN, Srivastava S, Dies KA, Swanson L, Costin C, Jobling RK, Pappas J, Rabin R, Niyazov D, Tsai AC, Kovak K, Beck DB, Malicdan M, Adams DR, Wolfe L, Ganetzky RD, Muraresku C, Babikyan D, Sedláček Z, Hančárová M, Timberlake AT, Al Saif H, Nestler B, King K, Hajianpour MJ, Costain G, Prendergast D, Li C, Geneviève D, Vitobello A, Sorlin A, Philippe C, Harel T, Toker O, Sabir A, Lim D, Hamilton M, Bryson L, Cleary E, Weber S, Hoffman TL, Cueto-González AM, Tizzano EF, Gómez-Andrés D, Codina-Solà M, Ververi A, Pavlidou E, Lambropoulos A, Garganis K, Rio M, Levy J, Jurgensmeyer S, McRae AM, Lessard MK, D'Agostino MD, De Bie I, Wegler M, Jamra RA, Kamphausen SB, Bothe V, Busch LM, Völker U, Hammer E, Wende K, Cogné B, Isidor B, Meiler J, Bosc-Rosati A, Marcoux J, Bousquet MP, Poschmann J, Laumonnier F, Hildebrand PW, Eichler EE, McWalter K, Krawitz PM, Droit A, Elgersma Y, Grabrucker AM, Bolduc FV, Bézieau S, Ebstein F, Krüger E

Unveiling the crucial neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies

Journal Article

medRxiv, 2024.

Abstract | Links:

Brodeur A, Roy V, Touzel-Deschênes L, Bianco S, Droit A, Fradette J, Ruel J, Gros-Louis F

Transcriptomic Analysis of Mineralized Adipose-Derived Stem Cell Tissues for Calcific Valve Disease Modelling

Journal Article

Int J Mol Sci, 25 (4), 2024.

Abstract | Links:

Lafleur S, Bodein A, Mbuya Malaïka Mutombo J, Mathieu A, Joly Beauparlant C, Minne X, Chandad F, Droit A, Houde VP

Multi-Omics Data Integration Reveals Key Variables Contributing to Subgingival Microbiome Dysbiosis-Induced Inflammatory Response in a Hyperglycemic Microenvironment

Journal Article

Int J Mol Sci, 24 (10), 2023.

Abstract | Links:

182 entries « 1 of 19 »
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Active projects

  • Biomarkers for prediction of venous thrombo-embolism in children with cancer, from 2024-01-23 to 2024-12-31
  • Caractérisation de la structure 3D et de la coloration des perles chez Pinctada sp. par analyse d’image., from 2021-01-01 to 2024-06-30
  • Caractérisation de nouveaux gènes de susceptibilité au cancer du sein, from 2024-02-15 to 2027-04-01
  • Chaire de recherche et d'innovation l'Oréal en biologie numérique, from 2016-05-16 to 2026-05-15
  • Characterization of novel breast cancer susceptibility genes through large-scale targeted sequencing and functional assays., from 2024-04-01 to 2029-03-31
  • Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada, from 2021-06-01 to 2025-03-31
  • Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in chronic neurodegenerative diseases, from 2020-03-01 to 2025-03-31
  • Dévelooppement d'algorithmes d'interprétation de modèles d'apprentissage profond pour la découverte de biomarqueurs, from 2020-04-01 to 2024-05-31
  • Development of high accuracy models for MICROB-AI, a new generation of diagnosis test for UTI, from 2021-07-01 to 2024-06-30
  • Développement de nouvelles approches immunothérapeutiques dirigées contre des néoantigènes dérivés de gènes de fusion pour le traitement de la leucémie aiguë pédiatrique, from 2022-06-15 to 2025-06-14
  • Développement de nouvelles connaissances sur les cibles biologiques du 2-hexénal en vue de son utilisation comme bioherbicide, from 2023-03-15 to 2026-03-14
  • Développement de solutions diagnostiques pour les troubles neurodéveloppementaux causés par un dysfonctionnement du système Ubiquitine-Protéasome, from 2023-02-01 to 2026-01-31
  • Développement de stratégies d'apprentissage automatisées pour déterminer les phénogroupes, la progression et les issues cliniques de la sténose valvulaire aortique, from 2022-12-06 to 2024-09-30
  • L’AIMZ-938, un nouveau promédicament anticancéreux pour le traitement des cancers du sein humain réfractaires aux traitements actuels et exprimant le cytochrome P450 1A1, from 2021-10-01 to 2026-09-30
  • MICROB-AI-R+, a new proteomics and AI-based technology for the detection of resistant pathogens in Urinary Tract Infections, from 2023-10-01 to 2025-09-30
  • Nouvelle approche intégrative de génomique du microbiome pour des luzernières plus durables, from 2022-07-01 to 2024-06-30
  • Outil d'intelligence artificielle pour l'identification rapide et précise des bactéries pathogènes chez les animaux et/ou chez l'humain dans le lait et les produits laitiers, from 2021-04-01 to 2025-03-31
  • Outil d'intelligence artificielle pour l'identification rapide et précise des micro-organismes dans le lait, from 2022-03-24 to 2025-04-30
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II), from 2017-11-01 to 2025-09-30
  • Personalized ultra-fast detection and treatment of resistant microbial infections, from 2023-03-31 to 2025-03-30
  • Prevention of the immunopathology induced by SARS-CoV-2, from 2021-06-01 to 2025-03-31
  • Role of megakaryocytes in Systemic Lupus Erythematosus, from 2023-04-01 to 2028-03-31
  • The interplay of sex hormones and chromosomes dictates pathogenicity in progressive CNS autoimmunity, from 2024-04-01 to 2029-03-31
  • Therapeutic approach to preserve Tfh cells and improve B cell immunity in simian immunodeficiency virus infected rhesus macaques, from 2021-04-01 to 2026-03-31

Recently finished projects

  • Artificial intelligence tool for fast and accurate identification of mastitis pathogenic and spoilage microorganisms in milk, from 2022-04-01 to 2024-03-31
  • Caribou Genomics : a National Non-Invasive Monitoring Approach for an Iconic and Model Species-at-Risk, from 2020-10-01 to 2023-09-30
  • Cellular mechanisms regulating the pathogenesis of secondary progressive CNS autoimmunity, from 2018-10-01 to 2023-03-31
  • Father's lasting influence: Molecular foundations of intergenerational transmission of the paternal environment, from 2014-11-01 to 2023-03-31
  • Identifying novel molecular insights from life science massive data, from 2018-04-01 to 2024-03-31
  • Influence de l’environnement leucémique dans le développement d’évènements thrombotiques chez les enfants atteints de leucémie lymphoblastique aigue traités dans l’essai thérapeutique international prospectif DFCI 16-001, from 2023-02-21 to 2024-03-31
  • Influence of hyperglycemia on the host-microbiome interactions during subgingival microbiome dysbiosis, from 2020-12-11 to 2023-06-10
  • Leveraging the impact of diversity in neurodevelopmental disability by integrating machine learning in personalized interventions, from 2020-02-01 to 2024-03-31
  • Nouvelle approche moléculaire pour la détection simultanée des virus pathogènes aux framboisiers et aux fraisiers, from 2019-08-01 to 2023-08-31
  • Observatoire international sur les impacts sociétaux de l'intelligence artificielle et du numérique, from 2018-04-01 to 2024-03-31
  • Predict to prevent: Advanced proteomics profiling for precision medicine, from 2021-03-23 to 2022-09-30
  • Une infrastructure IA multi-usagers clé en main pour gérer le cycle de vie complet des données en santé, from 2021-04-01 to 2023-12-01
  • Use of genomics to manage and protect caribou populations, from 2018-04-01 to 2022-12-31
  • Utilisation du séquençage à haut débit pour l’identification d’organismes pathogènes des plantes, from 2019-08-01 to 2023-08-31
Data provided by the Université Laval research projects registery