Arnaud Droit is an associate professor with the Department of Molecular Medicine at Laval University’s School of Medicine, and a researcher at the CHU de Québec–Laval University Research Centre, where he heads the bioinformatics and proteomics platform. He is also a member of the executive directorate of Laval University’s Big Data Research Centre (CRDM). Arnaud Droit studied biochemistry and bioinformatics at Université Toulouse III – Paul Sabatier, in France, and holds a PhD from Laval University.

Dr. Droit’s research program aims at developing new approaches and methods in computational genomics to analyze the genomic and proteomic data collected, effectively and thoroughly, using next-generation technology. His work is at the crossroads of biology and computer science.

Since 2016, he holds the L’Oréal Chair in Research and Innovation in Digital Biology, the first research chair in digital biology, which constitutes a center of excellence for the development of multi-omic big data technologies (which include the different fields of biology ending with the suffix « omic »: genomic, epigenomic, proteomic, metagenomic, etc.) and analyses.

Dr. Droit oversees a number of large-scale projects that address the challenges of managing massive data and extracting actionable knowledge for the life science community. One of his projects aims to aggregate many biological data sources, link them together, discover new relationships, and make them available on the Internet via dynamic visualization interfaces. He is also involved in the development of machine learning tools dedicated to clinical research and multi-omics data, which can also be extended to other areas. Other projects also cover temporal multi-omic data analysis, which requires the development of new approaches, and the identification of genes interacting together through the creation of coexpression networks.

Finally, Dr. Droit has established many international collaborations that allow him to cover a variety of fields in biology research, including oncology, immunology, and skin diseases.

CHUL
2705, boulevard Laurier
R-4720
Québec, Québec
Canada G1V 4G2
145 entries « 1 of 15 »

Raufaste-Cazavieille V, Santiago R, Droit A

Multi-omics analysis: Paving the path toward achieving precision medicine in cancer treatment and immuno-oncology

Journal Article

Front Mol Biosci, 9 , 2022.

Abstract | Links:

Carrier A, Prunier J, Poisson W, Trottier-Lavoie M, Gilbert I, Cavedon M, Pokharel K, Kantanen J, Musiani M, Côté SD, Albert V, Taillon J, Bourret V, Droit A, Robert C

Design and validation of a 63K genome-wide SNP-genotyping platform for caribou/reindeer (Rangifer tarandus)

Journal Article

BMC Genomics, 23 (1), 2022.

Abstract | Links:

Robin V, Bodein A, Scott-Boyer MP, Leclercq M, Périn O, Droit A

Overview of methods for characterization and visualization of a protein-protein interaction network in a multi-omics integration context

Journal Article

Front Mol Biosci, 9 , 2022.

Abstract | Links:

Aumailley L, Bourassa S, Gotti C, Droit A, Lebel M

Vitamin C modulates the levels of several proteins of the mitochondrial complex III and its activity in the mouse liver

Journal Article

Redox Biol, 57 , 2022.

Abstract | Links:

Helness A, Fraszczak J, Joly-Beauparlant C, Bagci H, Trahan C, Arman K, Shooshtarizadeh P, Chen R, Ayoub M, Côté JF, Oeffinger M, Droit A, Möröy T

Author Correction: GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors

Journal Article

Commun Biol, 5 (1), 2022.

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Dumont M, Weber-Lassalle N, Joly-Beauparlant C, Ernst C, Droit A, Feng BJ, Dubois S, Collin-Deschesnes AC, Soucy P, Vallée M, Fournier F, Lemaçon A, Adank MA, Allen J, Altmüller J, Arnold N, Ausems MGEM, Berutti R, Bolla MK, Bull S, Carvalho S, Cornelissen S, Dufault MR, Dunning AM, Engel C, Gehrig A, Geurts-Giele WRR, Gieger C, Green J, Hackmann K, Helmy M, Hentschel J, Hogervorst FBL, Hollestelle A, Hooning MJ, Horváth J, Ikram MA, Kaulfuß S, Keeman R, Kuang D, Luccarini C, Maier W, Martens JWM, Niederacher D, Nürnberg P, Ott CE, Peters A, Pharoah PDP, Ramirez A, Ramser J, Riedel-Heller S, Schmidt G, Shah M, Scherer M, Stäbler A, Strom TM, Sutter C, Thiele H, van Asperen CJ, van der Kolk L, van der Luijt RB, Volk AE, Wagner M, Waisfisz Q, Wang Q, Wang-Gohrke S, Weber BHF, Genome Of The Netherlands Project , Ghs Study Group , Devilee P, Tavtigian S, Bader GD, Meindl A, Goldgar DE, Andrulis IL, Schmutzler RK, Easton DF, Schmidt MK, Hahnen E, Simard J

Uncovering the Contribution of Moderate-Penetrance Susceptibility Genes to Breast Cancer by Whole-Exome Sequencing and Targeted Enrichment Sequencing of Candidate Genes in Women of European Ancestry

Journal Article

Cancers (Basel), 14 (14), 2022.

Abstract | Links:

Dubuc I, Prunier J, Lacasse É, Gravel A, Puhm F, Allaeys I, Archambault AS, Gudimard L, Villano R, Droit A, Flamand N, Boilard É, Flamand L

Cytokines and Lipid Mediators of Inflammation in Lungs of SARS-CoV-2 Infected Mice

Journal Article

Front Immunol, 13 , 2022.

Abstract | Links:

Sudarshan D, Avvakumov N, Lalonde ME, Alerasool N, Joly-Beauparlant C, Jacquet K, Mameri A, Lambert JP, Rousseau J, Lachance C, Paquet E, Herrmann L, Thonta Setty S, Loehr J, Bernardini MQ, Rouzbahman M, Gingras AC, Coulombe B, Droit A, Taipale M, Doyon Y, Côté J

Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci

Journal Article

Genes Dev, 36 (11-12), 2022.

Abstract | Links:

Setty ST, Scott-Boyer MP, Cuppens T, Droit A

New Developments and Possibilities in Reanalysis and Reinterpretation of Whole Exome Sequencing Datasets for Unsolved Rare Diseases Using Machine Learning Approaches

Journal Article

Int J Mol Sci, 23 (12), 2022.

Abstract | Links:

Devoucoux M, Roques C, Lachance C, Lashgari A, Joly-Beauparlant C, Jacquet K, Alerasool N, Prudente A, Taipale M, Droit A, Lambert JP, Hussein SMI, Côté J

MRG Proteins Are Shared by Multiple Protein Complexes With Distinct Functions

Journal Article

Mol Cell Proteomics, 21 (7), 2022.

Abstract | Links:

145 entries « 1 of 15 »
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Active projects

  • Caractérisation de la structure 3D et de la coloration des perles chez Pinctada sp. par analyse d’image., from 2021-01-01 to 2023-12-31
  • Caribou Genomics : a National Non-Invasive Monitoring Approach for an Iconic and Model Species-at-Risk, from 2020-10-01 to 2023-09-30
  • Cellular mechanisms regulating the pathogenesis of secondary progressive CNS autoimmunity, from 2018-10-01 to 2023-03-31
  • Chaire de recherche et d'innovation l'Oréal en biologie numérique, from 2016-05-16 to 2026-05-15
  • Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in chronic neurodegenerative diseases, from 2020-03-01 to 2025-03-31
  • Dévelooppement d'algorithmes d'interprétation de modèles d'apprentissage profond pour la découverte de biomarqueurs, from 2020-04-01 to 2023-12-31
  • Development of high accuracy models for MICROB-AI, a new generation of diagnosis test for UTI, from 2021-07-01 to 2023-06-30
  • Développement de nouvelles approches immunothérapeutiques dirigées contre des néoantigènes dérivés de gènes de fusion pour le traitement de la leucémie aiguë pédiatrique, from 2022-06-15 to 2025-06-14
  • Father's lasting influence: Molecular foundations of intergenerational transmission of the paternal environment, from 2014-11-01 to 2023-03-31
  • Identifying novel molecular insights from life science massive data, from 2018-04-01 to 2024-03-31
  • Influence of hyperglycemia on the host-microbiome interactions during subgingival microbiome dysbiosis, from 2020-12-11 to 2023-06-10
  • Leveraging the impact of diversity in neurodevelopmental disability by integrating machine learning in personalized interventions, from 2020-02-01 to 2023-01-31
  • L’AIMZ-938, un nouveau promédicament anticancéreux pour le traitement des cancers du sein humain réfractaires aux traitements actuels et exprimant le cytochrome P450 1A1, from 2021-10-01 to 2026-09-30
  • Nouvelle approche intégrative de génomique du microbiome pour des luzernières plus durables, from 2022-07-01 to 2024-06-30
  • Nouvelle approche moléculaire pour la détection simultanée des virus pathogènes aux framboisiers et aux fraisiers, from 2019-08-01 to 2023-08-31
  • Observatoire international sur les impacts sociétaux de l'intelligence artificielle et du numérique, from 2018-04-01 to 2024-03-31
  • Outil d'intelligence artificielle pour l'identification rapide et précise des bactéries pathogènes chez les animaux et/ou chez l'humain dans le lait et les produits laitiers, from 2021-04-01 to 2024-03-31
  • Outil d'intelligence artificielle pour l'identification rapide et précise des micro-organismes dans le lait, from 2022-03-24 to 2025-04-30
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II), from 2017-11-01 to 2024-03-31
  • Therapeutic approach to preserve Tfh cells and improve B cell immunity in simian immunodeficiency virus infected rhesus macaques, from 2021-04-01 to 2026-03-31
  • Use of genomics to manage and protect caribou populations, from 2018-04-01 to 2022-12-31
  • Utilisation du séquençage à haut débit pour l’identification d’organismes pathogènes des plantes, from 2019-08-01 to 2023-08-31

Recently finished projects

  • Calcul Québec, from 2015-04-01 to 2022-03-31
  • Computer-Aided Sperm Analysis (CASA) of sperm motility and hyperactivation, from 2021-04-01 to 2022-03-31
  • Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada, from 2021-06-01 to 2022-05-31
  • Development of Comprehensive Cytogenomics and Molecular Genetics Testing Using ans Exome and Low-Pass Whole Genome Sequencing Combined Approach, from 2019-01-01 to 2021-12-31
  • Développement d'approches par apprentissage actif et en budget contraint à partir de données de cardiologie, from 2021-08-01 to 2021-10-29
  • Développement d'un nouvel instrument d'analyse en temps réel pour la chirurgie guidée des cancers, from 2019-04-01 to 2021-03-31
  • Impact of the sperm epigenome on the progeny outcome born by assisted reproductive technology, from 2016-07-01 to 2021-12-31
  • Live viral spectroscopy for rapid Covid-19 detection applied directly to clinical biofluids without sample processing, from 2020-08-01 to 2021-07-31
  • Mise en place d’une application web d’aide à la visualisation et à l’interprétation des analyses de la qualité des sols en culture de pommes de terre, from 2019-05-17 to 2021-05-16
  • Predict to prevent: Advanced proteomics profiling for precision medicine, from 2021-03-23 to 2022-09-30
  • Prevention of the immunopathology induced by SARS-CoV-2, from 2021-06-01 to 2022-05-31
  • Une infrastructure IA multi-usagers clé en main pour gérer le cycle de vie complet des données en santé, from 2021-04-01 to 2022-08-31
Data provided by the Université Laval research projects registery