Dr. Ariane Mackey is a neurologist specializing in cerebrovascular diseases at the CHU of Quebec and Associate Professor of Medicine at Laval University. She is the Director of the Neurovascular Research Center, which consists of a team of neurologists specializing in cerebrovascular diseases, Dr. Steve Verreault and Dr. Marie-Christine Camden, as well as research nurses.

As a clinician and local principal investigator or co-investigator, she is actively involved in the review, as well as the implementation of large-scale multicentre clinical studies, either in the acute phase of ischemic or hemorrhagic stroke, as well as in secondary prevention, including carotid stenosis. The results of these studies sometimes lead to the rapid modification of practical guides on certain subjects, such as the CREST study which compared carotid endarterectomy to carotid stenting for patients with symptomatic or asymptomatic carotid stenosis. This study has shown that stent revascularization resulted in slightly more periprocedural stroke, while endarterectomy resulted in slightly more myocardial infarction. However, both procedures were found to be equally safe. It was also demonstrated, in agreement with other studies, that beyond 70 years of age, endarterectomy was the procedure of choice whereas, below 70 years of age, the stent was a very good option. The currently ongoing study on carotid stenosis is CREST 2; the goal is to demonstrate that maximal or even aggressive medical treatment would be as effective as stent or surgical revascularization in patients with asymptomatic severe stenosis.

The other main studies in progress concern patients who had a cryptogenic stroke, that is to say without a proven source of embolism, where we compare a direct anticoagulant versus aspirin alone. This aims to demonstrate whether a direct anticoagulant is more effective in preventing recurrence, while remaining safe in terms of the risk of bleeding.

The neurovascular team also participates in acute phase clinical trials of ischemic stroke with TNKase, as well as in a study to demonstrate the efficacy of a neuroprotective as adjunctive therapy to mechanical thrombectomy.

1401, 18e Rue
Z 254
Québec, Québec
Canada G1J 1Z4
+1 418-649-5892
+1 418-649-5896
ariane.mackey@chudequebec... ariane.mackey@crchudequeb...

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Jacova C, Pearce LA, Costello R, McClure LA, Holliday SL, Hart RG, Benavente OR

Cognitive impairment in lacunar strokes: the SPS3 trial

Journal Article

Ann Neurol, 72 (3), 2012.

Abstract | Links:

Howard VJ, Lutsep HL, Mackey A, Demaerschalk BM, Sam 2nd, Gonzales NR, Sheffet AJ, Voeks JH, Meschia JF, Brott TG,

Influence of sex on outcomes of stenting versus endarterectomy: a subgroup analysis of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST)

Journal Article

Lancet Neurol, 10 (6), 2011.

Abstract | Links:

Perry JJ, Sharma M, Sivilotti ML, Sutherland J, Symington C, Worster A, Emond M, Stotts G, Jin AY, Oczkowski WJ, Sahlas DJ, Murray HE, MacKey A, Verreault S, Wells GA, Stiell IG

Prospective validation of the ABCD2 score for patients in the emergency department with transient ischemic attack

Journal Article

CMAJ, 183 (10), 2011.

Abstract | Links:

Silver FL, Mackey A, Clark WM, Brooks W, Timaran CH, Chiu D, Goldstein LB, Meschia JF, Ferguson RD, Moore WS, Howard G, Brott TG,

Safety of stenting and endarterectomy by symptomatic status in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST)

Journal Article

Stroke, 42 (3), 2011.

Abstract | Links:

Bousser MG, Amarenco P, Chamorro A, Fisher M, Ford I, Fox KM, Hennerici MG, Mattle HP, Rothwell PM, de Cordoue A, Fratacci MD,

Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trial

Journal Article

Lancet, 377 (9782), 2011.

Abstract | Links:

Brott TG, Hobson 2nd, Howard G, Roubin GS, Clark WM, Brooks W, Mackey A, Hill MD, Leimgruber PP, Sheffet AJ, Howard VJ, Moore WS, Voeks JH, Hopkins LN, Cutlip DE, Cohen DJ, Popma JJ, Ferguson RD, Cohen SN, Blackshear JL, Silver FL, Mohr JP, Lal BK, Meschia JF,

Stenting versus endarterectomy for treatment of carotid-artery stenosis

Journal Article

N Engl J Med, 363 (1), 2010.

Abstract | Links:

Howard VJ, Voeks JH, Lutsep HL, Mackey A, Milot G, Sam 2nd, Tom M, Hughes SE, Sheffet AJ, Longbottom M, Avery JB, Hobson 2nd, Brott TG

Does sex matter? Thirty-day stroke and death rates after carotid artery stenting in women versus men: results from the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) lead-in phase

Journal Article

Stroke, 40 (4), 2009.

Abstract | Links:

Rodes-Cabau J, Noel M, Marrero A, Rivest D, Mackey A, Houde C, Bedard E, Larose E, Verreault S, Peticlerc M, Pibarot P, Bogaty P, Bertrand OF

Atherosclerotic burden findings in young cryptogenic stroke patients with and without a patent foramen ovale

Journal Article

Stroke, 40 (2), 2009.

Abstract | Links:

Rodes-Cabau J, Mineau S, Marrero A, Houde C, Mackey A, Cote JM, Chetaille P, Delisle G, Bertrand OF, Rivest D

Incidence, timing, and predictive factors of new-onset migraine headache attack after transcatheter closure of atrial septal defect or patent foramen ovale

Journal Article

Am J Cardiol, 101 (5), 2008.

Abstract | Links:

Bédard E, Rodés-Cabau J, Houde C, Mackey A, Rivest D, Cloutier S, Noël M, Marrero A, Côté JM, Chetaille P, Delisle G, Leblanc MH, Bertrand OF

Enhanced thrombogenesis but not platelet activation is associated with transcatheter closure of patent foramen ovale in patients with cryptogenic stroke

Journal Article

Stroke, 38 (1), 2007.

Abstract | Links:

51 entries « ‹ 5 of 6 › »
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Recently finished projects

  • Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2), from 2015-03-01 to 2022-12-25
Data provided by the Université Laval research projects registery