Dr. Ariane Mackey is a neurologist specializing in cerebrovascular diseases at the CHU of Quebec and Associate Professor of Medicine at Laval University. She is the Director of the Neurovascular Research Center, which consists of a team of neurologists specializing in cerebrovascular diseases, Dr. Steve Verreault and Dr. Marie-Christine Camden, as well as research nurses.

As a clinician and local principal investigator or co-investigator, she is actively involved in the review, as well as the implementation of large-scale multicentre clinical studies, either in the acute phase of ischemic or hemorrhagic stroke, as well as in secondary prevention, including carotid stenosis. The results of these studies sometimes lead to the rapid modification of practical guides on certain subjects, such as the CREST study which compared carotid endarterectomy to carotid stenting for patients with symptomatic or asymptomatic carotid stenosis. This study has shown that stent revascularization resulted in slightly more periprocedural stroke, while endarterectomy resulted in slightly more myocardial infarction. However, both procedures were found to be equally safe. It was also demonstrated, in agreement with other studies, that beyond 70 years of age, endarterectomy was the procedure of choice whereas, below 70 years of age, the stent was a very good option. The currently ongoing study on carotid stenosis is CREST 2; the goal is to demonstrate that maximal or even aggressive medical treatment would be as effective as stent or surgical revascularization in patients with asymptomatic severe stenosis.

The other main studies in progress concern patients who had a cryptogenic stroke, that is to say without a proven source of embolism, where we compare a direct anticoagulant versus aspirin alone. This aims to demonstrate whether a direct anticoagulant is more effective in preventing recurrence, while remaining safe in terms of the risk of bleeding.

The neurovascular team also participates in acute phase clinical trials of ischemic stroke with TNKase, as well as in a study to demonstrate the efficacy of a neuroprotective as adjunctive therapy to mechanical thrombectomy.

1401, 18e Rue
Z 254
Québec, Québec
Canada G1J 1Z4
+1 418-649-5892
+1 418-649-5896
ariane.mackey@chudequebec... ariane.mackey@crchudequeb...

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Hart RG, Sharma M, Mundl H, Kasner SE, Bangdiwala SI, Berkowitz SD, Swaminathan B, Lavados P, Wang Y, Davalos A, Shamalov N, Mikulik R, Cunha L, Lindgren A, Arauz A, Lang W, Czlonkowska A, Eckstein J, Gagliardi RJ, Amarenco P, Ameriso SF, Tatlisumak T, Veltkamp R, Hankey GJ, Toni D, Bereczki D, Uchiyama S, Ntaios G, Yoon BW, Brouns R, Endres M, Muir KW, Bornstein N, Ozturk S, O'Donnell MJ, De Vries Basson MM, Pare G, Pater C, Kirsch B, Sheridan P, Peters G, Weitz JI, Peacock WF, Shoamanesh A, Benavente OR, Joyner C, Themeles E, Connolly SJ,

Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source

Journal Article

N Engl J Med, 378 (23), 2018.

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Khandhar SJ, Bowling MR, Flandes J, Gildea TR, Hood KL, Krimsky WS, Minnich DJ, Murgu SD, Pritchett M, Toloza EM, Wahidi MM, Wolvers JJ, Folch EE,

Electromagnetic navigation bronchoscopy to access lung lesions in 1,000 subjects: first results of the prospective, multicenter NAVIGATE study

Journal Article

BMC Pulm Med, 17 (1), 2017.

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Masson-Roy J, Savard M, Mackey A

Carotid Cavernous Fistula in a Patient with Type IV Ehlers-Danlos Syndrome

Journal Article

Can J Neurol Sci, 44 (4), 2017.

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Michelson KN, Frader J, Sorce L, Clayman ML, Persell SD, Fragen P, Ciolino JD, Campbell LC, Arenson M, Aniciete DY, Brown ML, Ali FN, White D,

The Process and Impact of Stakeholder Engagement in Developing a Pediatric Intensive Care Unit Communication and Decision-Making Intervention

Journal Article

J Patient Exp, 3 (4), 2016.

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Wilson LK, Pearce LA, Arauz A, Anderson DC, Tapia J, Bazan C, Benavente OR, Field TS,

Morphological classification of penetrating artery pontine infarcts and association with risk factors and prognosis: The SPS3 trial

Journal Article

Int J Stroke, 11 (4), 2016.

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Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, Brass LM, Schwartz GG, Adams HP, Berger L, Carolei A, Clark W, Coull B, Ford GA, Kleindorfer D, O'Leary JR, Parsons MW, Ringleb P, Sen S, Spence JD, Tanne D, Wang D, Winder TR,

Pioglitazone after Ischemic Stroke or Transient Ischemic Attack

Journal Article

N Engl J Med, 374 (14), 2016.

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Johnston SC, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Jonasson J, Minematsu K, Molina CA, Wang Y, Wong KS,

Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack

Journal Article

N Engl J Med, 375 (1), 2016.

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Brott TG, Howard G, Roubin GS, Meschia JF, Mackey A, Brooks W, Moore WS, Hill MD, Mantese VA, Clark WM, Timaran CH, Heck D, Leimgruber PP, Sheffet AJ, Howard VJ, Chaturvedi S, Lal BK, Voeks JH, Hobson 2nd,

Long-Term Results of Stenting versus Endarterectomy for Carotid-Artery Stenosis

Journal Article

N Engl J Med, 374 (11), 2016.

Abstract | Links:

Lau H, White CL, Coffey C, Kase CS, Babikian VL, Pikula A, Romero JR, Nguyen T, Benavente OR,

Clinical Trial Participation and Health Behavior Modification: Secondary Prevention of Small Subcortical Strokes (SPS3)

Journal Article

J Neurol Disord Stroke, 3 (1), 2015.

Field TS, Pearce LA, Asinger RW, Smyth NG, De SK, Hart RG, Benavente OR,

Left Ventricular Geometry on Transthoracic Echocardiogram and Prognosis after Lacunar Stroke: The SPS3 Trial

Journal Article

J Stroke Cerebrovasc Dis, 24 (6), 2015.

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51 entries « ‹ 2 of 6 › »
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Recently finished projects

  • Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2), from 2015-03-01 to 2022-12-25
Data provided by the Université Laval research projects registery