Dr. Amélie Fradet-Turcotte, Ph.D., owns a Canada Research Chair in molecular virology and genomic instability and is an assistant professor in the Department of molecular biology, medical biochemistry and pathology of the Laval University School of Medicine. Recruited to the CHU de Québec research center in September 2015, she is a member of the St-Patrick Research Group in Fundamental Oncology and of Laval University’s Cancer Research Center (CRC).     

The main interest of Dr. Fradet-Turcotte’s laboratory is to understand how the mechanisms that safeguard genomic integrity in our cells are challenged during viral infections. Her laboratory uses a combination of molecular biology, biochemistry, and cellular biology to determine how the infection by DNA viruses such as the human papillomavirus (HPV) impacts the genomic integrity of the infected cell and to tackle how viruses usurp the DNA-damage machinery to promote the viral life cycle. Specifically, the work in her laboratory aims at elucidating the following questions: 1) What is the interplay between HPV and the DSB signaling and repair proteins, and how does it change during carcinogenesis? 2) How does HPV impact the functions of the reader of ubiquitylated chromatin in cancer cells? 3) What are the consequences of viral infection on DSB signaling and DNA repair pathway choice, and how does this affect the resistance of HPV+ cancer cells to current chemo- and radiotherapies?

Every day, many different types of DNA damage threaten the integrity of our genome. A failure to properly repair these alterations can result in the acquisition of hallmarks of cancer such as translocations and somatic mutations, or can lead to cell death. By using HPV as a model, the outcomes of these studies will not only improve our understanding of the mechanisms that safeguard genomic stability in our cells, but they will also have important implications for HPV-dependent cancer biology (cervical and oropharyngeal cancers), as well as for our understanding of the viral life cycle.

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45 entries « 5 of 5 »

Di Lello P, Miller Jenkins LM, Mas C, Langlois C, Malitskaya E, Fradet-Turcotte A, Archambault J, Legault P, Omichinski JG

p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH

Journal Article

Proc Natl Acad Sci U S A, 105 (1), 2008.

Abstract | Links:

Moody CA, Fradet-Turcotte A, Archambault J, Laimins LA

Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification

Journal Article

Proc Natl Acad Sci U S A, 104 (49), 2007.

Abstract | Links:

Fradet-Turcotte A, Vincent C, Joubert S, Bullock PA, Archambault J

Quantitative analysis of the binding of simian virus 40 large T antigen to DNA

Journal Article

J Virol, 81 (17), 2007.

Abstract | Links:

Kumar A, Meinke G, Reese DK, Moine S, Phelan PJ, Fradet-Turcotte A, Archambault J, Bohm A, Bullock PA

Model for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA

Journal Article

J Virol, 81 (9), 2007.

Abstract | Links:

Fradet-Turcotte A, Archambault J

Recent advances in the search for antiviral agents against human papillomaviruses

Journal Article

Antivir Ther, 12 (4), 2007.

Abstract | Links:

45 entries « 5 of 5 »
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Active projects

  • Chaire de recherche du Canada en virologie moléculaire et instabilité génomique, from 2022-09-01 to 2027-08-31
  • Collaboration entre les laboratoires d’Amélie Fradet-Turcotte (AFT) et Louis Flamand (LF) sur l’étude des mécanismes de réponses aux dommages à l’ADN et les infections virales, from 2023-04-24 to 2025-04-23
  • Deciphering the impact of chromatin modifications on DNA repair processes., from 2016-04-01 to 2025-03-31
  • Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines, from 2024-04-01 to 2030-03-31
  • Unraveling the molecular mechanisms that promote replication stress and resistance to chemoradiation in oropharyngeal cancer caused by human papillomavirus, from 2022-04-01 to 2027-03-31

Recently finished projects

  • Chaire de recherche du Canada en virologie moléculaire et instabilité génomique, from 2017-03-01 to 2022-08-31
  • Conférence Signalisation Québec 2022, from 2022-06-01 to 2023-05-31
  • Fonds Jeanne-et-Jean-Louis-Lévesque en soutien à la Chaire de recherche en virologie moléculaire et instabilité génomique, from 2017-03-01 to 2024-04-30
Data provided by the Université Laval research projects registery