Dr. Amélie Fradet-Turcotte, Ph.D., owns a Canada Research Chair in molecular virology and genomic instability and is an assistant professor in the Department of molecular biology, medical biochemistry and pathology of the Laval University School of Medicine. Recruited to the CHU de Québec research center in September 2015, she is a member of the St-Patrick Research Group in Fundamental Oncology and of Laval University’s Cancer Research Center (CRC).     

The main interest of Dr. Fradet-Turcotte’s laboratory is to understand how the mechanisms that safeguard genomic integrity in our cells are challenged during viral infections. Her laboratory uses a combination of molecular biology, biochemistry, and cellular biology to determine how the infection by DNA viruses such as the human papillomavirus (HPV) impacts the genomic integrity of the infected cell and to tackle how viruses usurp the DNA-damage machinery to promote the viral life cycle. Specifically, the work in her laboratory aims at elucidating the following questions: 1) What is the interplay between HPV and the DSB signaling and repair proteins, and how does it change during carcinogenesis? 2) How does HPV impact the functions of the reader of ubiquitylated chromatin in cancer cells? 3) What are the consequences of viral infection on DSB signaling and DNA repair pathway choice, and how does this affect the resistance of HPV+ cancer cells to current chemo- and radiotherapies?

Every day, many different types of DNA damage threaten the integrity of our genome. A failure to properly repair these alterations can result in the acquisition of hallmarks of cancer such as translocations and somatic mutations, or can lead to cell death. By using HPV as a model, the outcomes of these studies will not only improve our understanding of the mechanisms that safeguard genomic stability in our cells, but they will also have important implications for HPV-dependent cancer biology (cervical and oropharyngeal cancers), as well as for our understanding of the viral life cycle.

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Panier S, Ichijima Y, Fradet-Turcotte A, Leung CC, Kaustov L, Arrowsmith CH, Durocher D

Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks

Journal Article

Mol Cell, 47 (3), 2012.

Abstract | Links:

Lehoux M, Fradet-Turcotte A, Lussier-Price M, Omichinski JG, Archambault J

Inhibition of human papillomavirus DNA replication by an E1-derived p80/UAF1-binding peptide

Journal Article

J Virol, 86 (7), 2012.

Abstract | Links:

Meinke G, Phelan P, Fradet-Turcotte A, Archambault J, Bullock PA

Structure-based design of a disulfide-linked oligomeric form of the simian virus 40 (SV40) large T antigen DNA-binding domain

Journal Article

Acta Crystallogr D Biol Crystallogr, 67 (Pt 6), 2011.

Abstract | Links:

Fradet-Turcotte A, Bergeron-Labrecque F, Moody CA, Lehoux M, Laimins LA, Archambault J

Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response

Journal Article

J Virol, 85 (17), 2011.

Abstract | Links:

Morin G, Fradet-Turcotte A, Di Lello P, Bergeron-Labrecque F, Omichinski JG, Archambault J

A conserved amphipathic helix in the N-terminal regulatory region of the papillomavirus E1 helicase is required for efficient viral DNA replication

Journal Article

J Virol, 85 (11), 2011.

Abstract | Links:

Meinke G, Phelan PJ, Fradet-Turcotte A, Bohm A, Archambault J, Bullock PA

Structure-based analysis of the interaction between the simian virus 40 T-antigen origin binding domain and single-stranded DNA

Journal Article

J Virol, 85 (2), 2011.

Abstract | Links:

Fradet-Turcotte A, Morin G, Lehoux M, Bullock PA, Archambault J

Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication

Journal Article

Virology, 399 (1), 2010.

Abstract | Links:

Fradet-Turcotte A, Moody C, Laimins LA, Archambault J

Nuclear export of human papillomavirus type 31 E1 is regulated by Cdk2 phosphorylation and required for viral genome maintenance

Journal Article

J Virol, 84 (22), 2010.

Abstract | Links:

Gagnon D, Joubert S, Senechal H, Fradet-Turcotte A, Torre S, Archambault J

Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4

Journal Article

J Virol, 83 (9), 2009.

Abstract | Links:

Fradet-Turcotte A, Brault K, Titolo S, Howley PM, Archambault J

Characterization of papillomavirus E1 helicase mutants defective for interaction with the SUMO-conjugating enzyme Ubc9

Journal Article

Virology, 395 (2), 2009.

Abstract | Links:

46 entries « ‹ 4 of 5 › »
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Active projects

  • Chaire de recherche du Canada en virologie moléculaire et instabilité génomique, from 2022-09-01 to 2027-08-31
  • Collaboration entre les laboratoires d’Amélie Fradet-Turcotte (AFT) et Louis Flamand (LF) sur l’étude des mécanismes de réponses aux dommages à l’ADN et les infections virales, from 2023-04-24 to 2025-04-23
  • Deciphering the impact of chromatin modifications on DNA repair processes., from 2016-04-01 to 2025-03-31
  • Unraveling the molecular mechanisms that promote replication stress and resistance to chemoradiation in oropharyngeal cancer caused by human papillomavirus, from 2022-04-01 to 2027-03-31

Recently finished projects

  • Conférence Signalisation Québec 2022, from 2022-06-01 to 2023-05-31
  • Fonds Jeanne-et-Jean-Louis-Lévesque en soutien à la Chaire de recherche en virologie moléculaire et instabilité génomique, from 2017-03-01 to 2024-04-30
Data provided by the Université Laval research projects registery