Dr. Amélie Fradet-Turcotte, Ph.D., owns a Canada Research Chair in molecular virology and genomic instability and is an assistant professor in the Department of molecular biology, medical biochemistry and pathology of the Laval University School of Medicine. Recruited to the CHU de Québec research center in September 2015, she is a member of the St-Patrick Research Group in Fundamental Oncology and of Laval University’s Cancer Research Center (CRC).     

The main interest of Dr. Fradet-Turcotte’s laboratory is to understand how the mechanisms that safeguard genomic integrity in our cells are challenged during viral infections. Her laboratory uses a combination of molecular biology, biochemistry, and cellular biology to determine how the infection by DNA viruses such as the human papillomavirus (HPV) impacts the genomic integrity of the infected cell and to tackle how viruses usurp the DNA-damage machinery to promote the viral life cycle. Specifically, the work in her laboratory aims at elucidating the following questions: 1) What is the interplay between HPV and the DSB signaling and repair proteins, and how does it change during carcinogenesis? 2) How does HPV impact the functions of the reader of ubiquitylated chromatin in cancer cells? 3) What are the consequences of viral infection on DSB signaling and DNA repair pathway choice, and how does this affect the resistance of HPV+ cancer cells to current chemo- and radiotherapies?

Every day, many different types of DNA damage threaten the integrity of our genome. A failure to properly repair these alterations can result in the acquisition of hallmarks of cancer such as translocations and somatic mutations, or can lead to cell death. By using HPV as a model, the outcomes of these studies will not only improve our understanding of the mechanisms that safeguard genomic stability in our cells, but they will also have important implications for HPV-dependent cancer biology (cervical and oropharyngeal cancers), as well as for our understanding of the viral life cycle.

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Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, Cote J

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation

Journal Article

Mol Cell, 62 (3), 2016.

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Fradet-Turcotte A, Sitz J, Grapton D, Orthwein A

BRCA2 functions: from DNA repair to replication fork stabilization

Journal Article

Endocr Relat Cancer, 23 (10), 2016.

Abstract | Links:

Wilson MD, Benlekbir S, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, Durocher D

The structural basis of modified nucleosome recognition by 53BP1

Journal Article

Nature, 536 (7614), 2016.

Abstract | Links:

Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

Journal Article

Cell, 163 (6), 2015.

Abstract | Links:

Gagnon D, Fradet-Turcotte A, Archambault J

A quantitative and high-throughput assay of human papillomavirus DNA replication

Journal Article

Methods Mol Biol, 1249 , 2015.

Abstract | Links:

Lehoux M, Fradet-Turcotte A, Archambault J

Methods to assess the nucleocytoplasmic shuttling of the HPV E1 helicase and its effects on cellular proliferation and induction of a DNA damage response

Journal Article

Methods Mol Biol, 1249 , 2015.

Abstract | Links:

Orthwein A, Fradet-Turcotte A, Noordermeer SM, Canny MD, Brun CM, Strecker J, Escribano-Diaz C, Durocher D

Mitosis inhibits DNA double-strand break repair to guard against telomere fusions

Journal Article

Science, 344 (6180), 2014.

Abstract | Links:

Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks

Journal Article

Proc Natl Acad Sci U S A, 110 (52), 2013.

Abstract | Links:

Fradet-Turcotte A, Canny MD, Escribano-Diaz C, Orthwein A, Leung CC, Huang H, Landry MC, Kitevski-LeBlanc J, Noordermeer SM, Sicheri F, Durocher D

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

Journal Article

Nature, 499 (7456), 2013.

Abstract | Links:

Escribano-Diaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, Tkac J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D, Durocher D

A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

Journal Article

Mol Cell, 49 (5), 2013.

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Active projects

  • Chaire de recherche du Canada en virologie moléculaire et instabilité génomique, from 2022-09-01 to 2027-08-31
  • Collaboration entre les laboratoires d’Amélie Fradet-Turcotte (AFT) et Louis Flamand (LF) sur l’étude des mécanismes de réponses aux dommages à l’ADN et les infections virales, from 2023-04-24 to 2025-04-23
  • Deciphering the impact of chromatin modifications on DNA repair processes., from 2016-04-01 to 2025-03-31
  • Unraveling the molecular mechanisms that promote replication stress and resistance to chemoradiation in oropharyngeal cancer caused by human papillomavirus, from 2022-04-01 to 2027-03-31

Recently finished projects

  • Conférence Signalisation Québec 2022, from 2022-06-01 to 2023-05-31
  • Fonds Jeanne-et-Jean-Louis-Lévesque en soutien à la Chaire de recherche en virologie moléculaire et instabilité génomique, from 2017-03-01 to 2024-04-30
Data provided by the Université Laval research projects registery