Dr. Amélie Fradet-Turcotte, Ph.D., owns a Canada Research Chair in molecular virology and genomic instability and is an assistant professor in the Department of molecular biology, medical biochemistry and pathology of the Laval University School of Medicine. Recruited to the CHU de Québec research center in September 2015, she is a member of the St-Patrick Research Group in Fundamental Oncology and of Laval University’s Cancer Research Center (CRC).     

The main interest of Dr. Fradet-Turcotte’s laboratory is to understand how the mechanisms that safeguard genomic integrity in our cells are challenged during viral infections. Her laboratory uses a combination of molecular biology, biochemistry, and cellular biology to determine how the infection by DNA viruses such as the human papillomavirus (HPV) impacts the genomic integrity of the infected cell and to tackle how viruses usurp the DNA-damage machinery to promote the viral life cycle. Specifically, the work in her laboratory aims at elucidating the following questions: 1) What is the interplay between HPV and the DSB signaling and repair proteins, and how does it change during carcinogenesis? 2) How does HPV impact the functions of the reader of ubiquitylated chromatin in cancer cells? 3) What are the consequences of viral infection on DSB signaling and DNA repair pathway choice, and how does this affect the resistance of HPV+ cancer cells to current chemo- and radiotherapies?

Every day, many different types of DNA damage threaten the integrity of our genome. A failure to properly repair these alterations can result in the acquisition of hallmarks of cancer such as translocations and somatic mutations, or can lead to cell death. By using HPV as a model, the outcomes of these studies will not only improve our understanding of the mechanisms that safeguard genomic stability in our cells, but they will also have important implications for HPV-dependent cancer biology (cervical and oropharyngeal cancers), as well as for our understanding of the viral life cycle.

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Devoucoux M, Fort V, Khelifi G, Xu J, Alerasool N, Galloy M, Wong N, Bourriquen G, Fradet-Turcotte A, Taipale M, Hope K, Hussein SMI, Côté J

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes

Journal Article

Cell Rep, 39 (11), 2022.

Abstract | Links:

Agbo L, Blanchet SA, Kougnassoukou Tchara PE, Fradet-Turcotte A, Lambert JP

Comprehensive Interactome Mapping of Nuclear Receptors Using Proximity Biotinylation

Journal Article

Methods Mol Biol, 2456 , 2022.

Abstract | Links:

Sherker A, Chaudhary N, Adam S, Heijink AM, Noordermeer SM, Fradet-Turcotte A, Durocher D

Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites

Journal Article

EMBO Rep, 22 (12), 2021.

Abstract | Links:

Luthold C, Lambert H, Guilbert SM, Rodrigue MA, Fuchs M, Varlet AA, Fradet-Turcotte A, Lavoie JN

CDK1-Mediated Phosphorylation of BAG3 Promotes Mitotic Cell Shape Remodeling and the Molecular Assembly of Mitotic p62 Bodies

Journal Article

Cells, 10 (10), 2021.

Abstract | Links:

Galloy M, Lachance C, Cheng X, Distéfano-Gagné F, Côté J, Fradet-Turcotte A

Approaches to Study Native Chromatin-Modifying Complex Activities and Functions

Journal Article

Front Cell Dev Biol, 9 , 2021.

Abstract | Links:

Krassowski M, Pellegrina D, Mee MW, Fradet-Turcotte A, Bhat M, Reimand J

ActiveDriverDB: Interpreting Genetic Variation in Human and Cancer Genomes Using Post-translational Modification Sites and Signaling Networks (2021 Update)

Journal Article

Front Cell Dev Biol, 9 , 2021.

Abstract | Links:

Sitz J, Blanchet SA, Gameiro SF, Biquand E, Morgan TM, Galloy M, Dessapt J, Lavoie EG, Blondeau A, Smith BC, Mymryk JS, Moody CA, Fradet-Turcotte A

Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response

Journal Article

Proc Natl Acad Sci U S A, 116 (39), 2019.

Abstract | Links:

Salamun SG, Sitz J, De La Cruz-Herrera CF, Yockteng-Melgar J, Marcon E, Greenblatt J, Fradet-Turcotte A, Frappier L

The Epstein-Barr Virus BMRF1 Protein Activates Transcription and Inhibits the DNA Damage Response by Binding NuRD

Journal Article

J Virol, 93 (22), 2019.

Abstract | Links:

Weitzman MD, Fradet-Turcotte A

Virus DNA Replication and the Host DNA Damage Response

Journal Article

Annu Rev Virol, 5 (1), 2018.

Abstract | Links:

Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency

Journal Article

Nat Biotechnol, 36 (1), 2018.

Abstract | Links:

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Active projects

  • Chaire de recherche du Canada en virologie moléculaire et instabilité génomique, from 2017-03-01 to 2022-08-31
  • Deciphering the impact of chromatin modifications on DNA repair processes., from 2016-04-01 to 2023-03-31
  • Fonds Jeanne-et-Jean-Louis-Lévesque en soutien à la Chaire de recherche en virologie moléculaire et instabilité génomique, from 2017-03-01 to 2024-04-30
  • Unraveling the molecular mechanisms that promote replication stress and resistance to chemoradiation in oropharyngeal cancer caused by human papillomavirus, from 2022-04-01 to 2027-03-31

Recently finished projects

  • Characterisation of PTM-associated mutations that alter signaling network in breast and ovarian cancers, from 2019-09-01 to 2021-08-31
  • Defining the molecular basis of chemoradiation sensitivity in HPV+ head and neck cancers, from 2017-04-01 to 2022-03-31
  • Engineering HPV oncoprotein E6 for inhibitors of cancer progression, from 2019-08-01 to 2021-07-31
Data provided by the Université Laval research projects registery