Dr. Amélie Fradet-Turcotte, Ph.D., owns a Canada Research Chair in molecular virology and genomic instability and is an assistant professor in the Department of molecular biology, medical biochemistry and pathology of the Laval University School of Medicine. Recruited to the CHU de Québec research center in September 2015, she is a member of the St-Patrick Research Group in Fundamental Oncology and of Laval University’s Cancer Research Center (CRC).     

The main interest of Dr. Fradet-Turcotte’s laboratory is to understand how the mechanisms that safeguard genomic integrity in our cells are challenged during viral infections. Her laboratory uses a combination of molecular biology, biochemistry, and cellular biology to determine how the infection by DNA viruses such as the human papillomavirus (HPV) impacts the genomic integrity of the infected cell and to tackle how viruses usurp the DNA-damage machinery to promote the viral life cycle. Specifically, the work in her laboratory aims at elucidating the following questions: 1) What is the interplay between HPV and the DSB signaling and repair proteins, and how does it change during carcinogenesis? 2) How does HPV impact the functions of the reader of ubiquitylated chromatin in cancer cells? 3) What are the consequences of viral infection on DSB signaling and DNA repair pathway choice, and how does this affect the resistance of HPV+ cancer cells to current chemo- and radiotherapies?

Every day, many different types of DNA damage threaten the integrity of our genome. A failure to properly repair these alterations can result in the acquisition of hallmarks of cancer such as translocations and somatic mutations, or can lead to cell death. By using HPV as a model, the outcomes of these studies will not only improve our understanding of the mechanisms that safeguard genomic stability in our cells, but they will also have important implications for HPV-dependent cancer biology (cervical and oropharyngeal cancers), as well as for our understanding of the viral life cycle.

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45 entries « 1 of 5 »

Collin V, Biquand É, Tremblay V, Lavoie ÉG, Blondeau A, Gravel A, Galloy M, Lashgari A, Dessapt J, Côté J, Flamand L, Fradet-Turcotte A

The immediate-early protein 1 of human herpesvirus 6B interacts with NBS1 and inhibits ATM signaling

Journal Article

EMBO Rep, 25 (2), 2024.

Abstract | Links:

Pinedo-Carpio E, Dessapt J, Beneyton A, Sacre L, Bérubé MA, Villot R, Lavoie EG, Coulombe Y, Blondeau A, Boulais J, Malina A, Luo VM, Lazaratos AM, Côté JF, Mallette FA, Guarné A, Masson JY, Fradet-Turcotte A, Orthwein A

FIRRM cooperates with FIGNL1 to promote RAD51 disassembly during DNA repair

Journal Article

Sci Adv, 9 (32), 2023.

Abstract | Links:

Gao Y, Guitton-Sert L, Dessapt J, Coulombe Y, Rodrigue A, Milano L, Blondeau A, Larsen NB, Duxin JP, Hussein S, Fradet-Turcotte A, Masson JY

A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene

Journal Article

Nat Commun, 14 (1), 2023.

Abstract | Links:

Becht DC, Klein BJ, Kanai A, Jang SM, Cox KL, Zhou BR, Phanor SK, Zhang Y, Chen RW, Ebmeier CC, Lachance C, Galloy M, Fradet-Turcotte A, Bulyk ML, Bai Y, Poirier MG, Côté J, Yokoyama A, Kutateladze TG

MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain

Journal Article

Nat Commun, 14 (1), 2023.

Abstract | Links:

Stok C, Tsaridou S, van den Tempel N, Everts M, Wierenga E, Bakker FJ, Kok Y, Alves IT, Jae LT, Raas MWD, Huis In 't Veld PJ, de Boer HR, Bhattacharya A, Karanika E, Warner H, Chen M, van de Kooij B, Dessapt J, Ter Morsche L, Perepelkina P, Fradet-Turcotte A, Guryev V, Tromer EC, Chan KL, Fehrmann RSN, van Vugt MATM

FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics

Journal Article

Cell Rep, 42 (7), 2023.

Abstract | Links:

Binda O, Kimenyi Ishimwe AB, Galloy M, Jacquet K, Corpet A, Fradet-Turcotte A, Côté J, Lomonte P

The TUDOR domain of SMN is an H3K79me1 histone mark reader

Journal Article

Life Sci Alliance, 6 (6), 2023.

Abstract | Links:

Agbo L, Blanchet SA, Kougnassoukou Tchara PE, Fradet-Turcotte A, Lambert JP

Comprehensive Interactome Mapping of Nuclear Receptors Using Proximity Biotinylation

Journal Article

Methods Mol Biol, 2456 , 2022.

Abstract | Links:

Devoucoux M, Fort V, Khelifi G, Xu J, Alerasool N, Galloy M, Wong N, Bourriquen G, Fradet-Turcotte A, Taipale M, Hope K, Hussein SMI, Côté J

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes

Journal Article

Cell Rep, 39 (11), 2022.

Abstract | Links:

Krassowski M, Pellegrina D, Mee MW, Fradet-Turcotte A, Bhat M, Reimand J

ActiveDriverDB: Interpreting Genetic Variation in Human and Cancer Genomes Using Post-translational Modification Sites and Signaling Networks (2021 Update)

Journal Article

Front Cell Dev Biol, 9 , 2021.

Abstract | Links:

Galloy M, Lachance C, Cheng X, Distéfano-Gagné F, Côté J, Fradet-Turcotte A

Approaches to Study Native Chromatin-Modifying Complex Activities and Functions

Journal Article

Front Cell Dev Biol, 9 , 2021.

Abstract | Links:

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Active projects

  • Chaire de recherche du Canada en virologie moléculaire et instabilité génomique, from 2022-09-01 to 2027-08-31
  • Collaboration entre les laboratoires d’Amélie Fradet-Turcotte (AFT) et Louis Flamand (LF) sur l’étude des mécanismes de réponses aux dommages à l’ADN et les infections virales, from 2023-04-24 to 2025-04-23
  • Deciphering the impact of chromatin modifications on DNA repair processes., from 2016-04-01 to 2025-03-31
  • Fonds Jeanne-et-Jean-Louis-Lévesque en soutien à la Chaire de recherche en virologie moléculaire et instabilité génomique, from 2017-03-01 to 2024-04-30
  • Unraveling the molecular mechanisms that promote replication stress and resistance to chemoradiation in oropharyngeal cancer caused by human papillomavirus, from 2022-04-01 to 2027-03-31

Recently finished projects

  • Chaire de recherche du Canada en virologie moléculaire et instabilité génomique, from 2017-03-01 to 2022-08-31
  • Conférence Signalisation Québec 2022, from 2022-06-01 to 2023-05-31
Data provided by the Université Laval research projects registery