Dr. Agharazii is a nephrologist, clinician-researcher, director of the Endocrinology and Nephrology research axis of Quebec’s CRCHU. He is Professor of Medicine in the Department of Medicine at Laval University and is the Residency Program Director for Nephrology. He holds the Amgen-U. Laval Nephrology Research Chair. His work focuses on arterial stiffness, which is a consequence of vascular aging and is particularly accelerated in patients with renal failure. Arterial stiffness is the main determinant of isolated high blood pressure commonly seen in the elderly as well as in diabetic and renally impaired patients. Although there are several medications available to treat hypertension, current medications were not designed to target arterial stiffness, sometimes leading to treatment failures and causing side effects related to polypharmacy. It is therefore important to understand the mechanisms involved in the development of arterial stiffness in order to develop specific therapeutic targets.

His research program aims to elucidate the role of inflammation, bone mineral disorder and endothelin in the pathophysiology of vascular remodeling in renal failure. His research involves patient care, the use of animal models and cell cultures, and the collaboration of several researchers.

L'Hôtel-Dieu de Québec
6 rue McMahon
1896-2
Québec, QC
Canada G1R 3S1
+1 418-525-4444, extension 15585
+1 418-691-5562
Mohsen.Agharazii@crchudeq...

Latest news

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Obeid H, Fortier C, Garneau CA, Pare M, Boutouyrie P, Bruno RM, Khettab H, Goupil R, Agharazii M

Radial-digital pulse wave velocity: a noninvasive method for assessing stiffness of small conduit arteries

Journal Article

Am J Physiol Heart Circ Physiol, 320 (4), 2021.

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Agharazii M

Coagulation anomalies, endothelial dysfunction, and aortic stiffness

Journal Article

Kidney Int, 99 (5), 2021.

Abstract | Links:

Lamarche F, Agharazii M, Madore F, Goupil R

Prediction of Cardiovascular Events by Type I Central Systolic Blood Pressure: A Prospective Study

Journal Article

Hypertension, 77 (2), 2021.

Abstract | Links:

Dupuis ME, Nadeau-Fredette AC, Madore F, Agharazii M, Goupil R

Association of Glomerular Hyperfiltration and Cardiovascular Risk in Middle-Aged Healthy Individuals

Journal Article

JAMA Netw Open, 3 (4), 2020.

Abstract | Links:

Rodriguez RA, Spence M, Hae R, Agharazii M, Burns KD

Pharmacologic Therapies for Aortic Stiffness in End-Stage Renal Disease: A Systematic Review and Meta-Analysis

Journal Article

Can J Kidney Health Dis, 7 , 2020.

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Cote G, Asselin-Thompstone L, Mac-Way F, Rene de Cotret P, Lacroix C, Desmeules S, Agharazii M

Sodium and urea excretion as determinants of urine output in autosomal dominant polycystic kidney disease patients on V2 receptor antagonists: impact of dietary intervention

Journal Article

Int Urol Nephrol, 52 (2), 2020.

Abstract | Links:

Pare M, Goupil R, Fortier C, Mac-Way F, Madore F, Marquis K, Hametner B, Wassertheurer S, Schultz MG, Sharman JE, Agharazii M

Determinants of Increased Central Excess Pressure in Dialysis: Role of Dialysis Modality and Arteriovenous Fistula

Journal Article

Am J Hypertens, 33 (2), 2020.

Abstract | Links:

Rodriguez RA, Hae R, Spence M, Shea B, Agharazii M, Burns KD

A Systematic Review and Meta-analysis of Nonpharmacologic-based Interventions for Aortic Stiffness in End-Stage Renal Disease

Journal Article

Kidney Int Rep, 4 (8), 2019.

Abstract | Links:

Fortier C, Cote G, Mac-Way F, Goupil R, Desbiens LC, Desjardins MP, Marquis K, Hametner B, Wassertheurer S, Schultz MG, Sharman JE, Agharazii M

Prognostic Value of Carotid and Radial Artery Reservoir-Wave Parameters in End-Stage Renal Disease

Journal Article

J Am Heart Assoc, 8 (13), 2019.

Abstract | Links:

Bisson SK, Ung RV, Picard S, Valade D, Agharazii M, Larivière R, Mac-Way F

High calcium, phosphate and calcitriol supplementation leads to an osteocyte-like phenotype in calcified vessels and bone mineralisation defect in uremic rats

Journal Article

J Bone Miner Metab, 37 (2), 2019.

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104 entries « ‹ 3 of 11 › »
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Active projects

  • Activités de réseautage de recherche en cardiologie, endocrinogie et néphrologie (CENNE), from 2022-05-01 to 2025-04-30
  • Arterial stiffness gradient as a new index of vascular aging: impact of blood pressure lowering medication, from 2019-10-01 to 2024-09-30
  • Characterizing Cardiovascular Outcomes in Subclinical Primary Aldosteronism, from 2021-04-01 to 2024-03-31
  • Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada, from 2021-06-01 to 2024-05-31
  • Early Prediction of preeclampsia Using arteriaL Stiffness in high-risk prEgnancies; a multinational study (PULSE), from 2020-04-01 to 2025-03-31
  • Hydrochlorothiazide and accelerated CKD-related vascular calcification, from 2023-07-01 to 2025-06-30
  • Identifying low bone turnover disease in chronic kidney disease in order to guide anti-fracture therapy, from 2020-10-01 to 2025-09-30
  • Mécanismes de la rigidité aortique en insuffisance rénale chez l'humain, from 2018-06-01 to 2025-03-31
  • Towards a virtual cardiovascular system for understanding arterial stiffness and blood flow, from 2023-04-01 to 2028-03-31
  • Transgenic rats overexpressing HDAC9 to explore the missing link between osteoporosis and vascular disease in chronic kidney disease, from 2023-06-21 to 2024-03-31

Recently finished projects

  • Accelerated CKD-related vascular calcification: Role of thiazide-type, thiazide-like and loop diuretics, from 2020-10-01 to 2023-05-31
  • CENTRAL-CKD Cibler la pression artérielle centrale : Une étude pilote randomisée-contrôlée pragmatique pour les palients avec insuffisance rénale chronique avancée , from 2021-10-01 to 2023-09-30
  • Non-invasive measurement of arterial stiffness of microcirculation in humans: an integrated approach, from 2020-01-20 to 2022-04-30
  • Traiter l’os pour prévenir l’hypertension et les maladies cardiovasculaires chez les femmes ménopausées., from 2021-05-01 to 2023-06-30
Data provided by the Université Laval research projects registery