Dr. Agharazii is a nephrologist, clinician-researcher, director of the Endocrinology and Nephrology research axis of Quebec’s CRCHU. He is Professor of Medicine in the Department of Medicine at Laval University and is the Residency Program Director for Nephrology. He holds the Amgen-U. Laval Nephrology Research Chair. His work focuses on arterial stiffness, which is a consequence of vascular aging and is particularly accelerated in patients with renal failure. Arterial stiffness is the main determinant of isolated high blood pressure commonly seen in the elderly as well as in diabetic and renally impaired patients. Although there are several medications available to treat hypertension, current medications were not designed to target arterial stiffness, sometimes leading to treatment failures and causing side effects related to polypharmacy. It is therefore important to understand the mechanisms involved in the development of arterial stiffness in order to develop specific therapeutic targets.

His research program aims to elucidate the role of inflammation, bone mineral disorder and endothelin in the pathophysiology of vascular remodeling in renal failure. His research involves patient care, the use of animal models and cell cultures, and the collaboration of several researchers.

L'Hôtel-Dieu de Québec
10, rue McMahon
0886
Québec, Québec
Canada G1R 2J6
+1 418-525-4444, extension 15585
+1 418-691-5562
Mohsen.Agharazii@crchudeq...

Latest news

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Paré M, Goupil R, Fortier C, Mac-Way F, Madore F, Hametner B, Wassertheurer S, Schultz MG, Sharman JE, Agharazii M

Increased Excess Pressure After Creation of an Arteriovenous Fistula in End-Stage Renal Disease

Journal Article

Am J Hypertens, 35 (2), 2022.

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Hundemer GL, Imsirovic H, Vaidya A, Yozamp N, Goupil R, Madore F, Agharazii M, Knoll G, Sood MM

Screening Rates for Primary Aldosteronism Among Individuals With Hypertension Plus Hypokalemia: A Population-Based Retrospective Cohort Study

Journal Article

Hypertension, 79 (1), 2022.

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Fortier C, Garneau CA, Paré M, Obeid H, Côté N, Duval K, Goupil R, Agharazii M

Modulation of Arterial Stiffness Gradient by Acute Administration of Nitroglycerin

Journal Article

Front Physiol, 12 , 2021.

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Rodriguez RA, Trentin Sonoda M, Agharazii M, Shorr R, Burns KD

Effects of living kidney donation on arterial stiffness: a systematic review protocol

Journal Article

BMJ Open, 11 (3), 2021.

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Fortier C, Obeid H, Paré M, Garneau CA, Sidibé A, Boutouyrie P, Agharazii M

Changes in arterial stiffness indices during a single haemodialysis session in end-stage renal disease population: a systematic review and meta-analysis protocol

Journal Article

BMJ Open, 11 (9), 2021.

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Boyer A, Begin Y, Dupont J, Rousseau-Gagnon M, Fernandez N, Demian M, Simonyan D, Agharazii M, Mac-Way F

Health literacy level in a various nephrology population from Québec: predialysis clinic, in-centre hemodialysis and home dialysis; a transversal monocentric observational study

Journal Article

BMC Nephrol, 22 (1), 2021.

Abstract | Links:

Kowalski C, Yang K, Charron T, Doucet M, Hatem R, Kouz R, Palisaitis D, Schampaert E, Terriault P, Tessier P, Agharazii M, Goupil R

Inaccuracy of brachial blood pressure and its potential impact on treatment and aortic blood pressure estimation

Journal Article

J Hypertens, 39 (12), 2021.

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Parent-Roberge H, Deshayes TA, Fortier C, Marquis K, Lacharité-Lemieux C, Rodrigue C, Dionne IJ, Agharazii M, Godin M, Riesco E

Feasibility of an Intradialytic Combined Exercise Program Targeting Older Adults With End-Stage Renal Disease

Journal Article

J Aging Phys Act, 29 (6), 2021.

Abstract | Links:

Obeid H, Fortier C, Garneau CA, Pare M, Boutouyrie P, Bruno RM, Khettab H, Goupil R, Agharazii M

Radial-digital pulse wave velocity: a noninvasive method for assessing stiffness of small conduit arteries

Journal Article

Am J Physiol Heart Circ Physiol, 320 (4), 2021.

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Agharazii M

Coagulation anomalies, endothelial dysfunction, and aortic stiffness

Journal Article

Kidney Int, 99 (5), 2021.

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102 entries « ‹ 2 of 11 › »
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Active projects

  • Activités de réseautage de recherche en cardiologie, endocrinogie et néphrologie (CENNE), from 2022-05-01 to 2025-04-30
  • Arterial stiffness gradient as a new index of vascular aging: impact of blood pressure lowering medication, from 2019-10-01 to 2024-09-30
  • CENTRAL-CKD Cibler la pression artérielle centrale : Une étude pilote randomisée-contrôlée pragmatique pour les palients avec insuffisance rénale chronique avancée , from 2021-10-01 to 2023-09-30
  • Characterizing Cardiovascular Outcomes in Subclinical Primary Aldosteronism, from 2021-04-01 to 2024-03-31
  • Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada, from 2021-06-01 to 2024-05-31
  • Early Prediction of preeclampsia Using arteriaL Stiffness in high-risk prEgnancies; a multinational study (PULSE), from 2020-04-01 to 2025-03-31
  • Identifying low bone turnover disease in chronic kidney disease in order to guide anti-fracture therapy, from 2020-10-01 to 2025-09-30
  • Mécanismes de la rigidité aortique en insuffisance rénale chez l'humain, from 2018-06-01 to 2025-03-31
  • Towards a virtual cardiovascular system for understanding arterial stiffness and blood flow, from 2023-04-01 to 2028-03-31
  • Traiter l’os pour prévenir l’hypertension et les maladies cardiovasculaires chez les femmes ménopausées., from 2021-05-01 to 2023-06-30

Recently finished projects

  • Accelerated CKD-related vascular calcification: Role of thiazide-type, thiazide-like and loop diuretics, from 2020-10-01 to 2023-05-31
  • Non-invasive measurement of arterial stiffness of microcirculation in humans: an integrated approach, from 2020-01-20 to 2022-04-30
Data provided by the Université Laval research projects registery