Dr. Luc Vallières is a Professor in the Department of Molecular Medicine at Laval University and a neuroimmunology researcher in the Neuroscience Unit at the CHU de Québec.

He began his career in 2002 after a postdoctoral training at the Salk Institute in California in the field of postnatal neurogenesis (1998-2001). This training was preceded by a doctorate in physiology at Laval University (1993-1998) and a bachelor’s degree in biology at the Université du Québec à Chicoutimi (1990-1993).

He is studying two diseases that afflict the central nervous system: multiple sclerosis and brain cancer. His research program aims to better understand how immune cells are regulated in these diseases in the hope of finding a way to neutralize or stimulate them for therapeutic purposes. This program is well funded by the CIHR, NSERC and Multiple Sclerosis Society of Canada.

He has made a significant contribution to the field of neuroimmunology by discovering a population of immune cells that constantly patrols the blood vessels of the nervous system and by elucidating mechanisms that govern their recruitment and functions under inflammatory conditions.

His research led to an international patent claiming the first ever drug that would specifically calm the neutrophil, an immune cell normally beneficial, but that can be involved in many inflammatory diseases.

His technical background includes single cell-RNA sequencing, STED super-resolution microscopy, flow cytometry, CRISPR-Cas9 gene editing and RNA interference, as well as bone marrow transplantation. Strong of this expertise, he directs the super-resolution microscopy and irradiation platforms at the CHU de Québec.

He is responsible of two courses, namely Principles of Neuroimmunology (MMO-7010) and Current Techniques in Molecular Medicine (MMO-7019).

Among his external activities, he is chairing the organizing committee of the 16th Congress of the International Society of Neuroimmunology, which will take place in Quebec City in August 2022. He is associate editor of the journal Mediators of Inflammation. He also serves on neuroscience committees at the CIHR.

CHUL
2705, boulevard Laurier
T2-41
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46233
luc.vallieres@crchudequeb...

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El Hajj H, Savage JC, Bisht K, Parent M, Vallières L, Rivest S, Tremblay MÈ

Ultrastructural evidence of microglial heterogeneity in Alzheimer's disease amyloid pathology

Journal Article

J Neuroinflammation, 16 (1), 2019.

Abstract | Links:

Whittaker Hawkins RF, Patenaude A, Dumas A, Jain R, Tesfagiorgis Y, Kerfoot S, Matsui T, Gunzer M, Poubelle PE, Larochelle C, Pelletier M, Vallieres L

ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell-dependent autoimmune encephalomyelitis

Journal Article

JCI Insight, 2 (23), 2017.

Abstract | Links:

Casserly CS, Nantes JC, Whittaker Hawkins RF, Vallieres L

Neutrophil perversion in demyelinating autoimmune diseases: Mechanisms to medicine

Journal Article

Autoimmun Rev, 16 (3), 2017.

Abstract | Links:

Bisht K, Sharma KP, Lecours C, Sánchez MG, El Hajj H, Milior G, Olmos-Alonso A, Gomez-Nicola D, Luheshi G, Vallieres L, Branchi I, Maggi L, Limatola C, Butovsky O, Tremblay ME

Dark microglia: A new phenotype predominantly associated with pathological states

Journal Article

Glia, 64 (5), 2016.

Abstract | Links:

Skrzeczynska-Moncznik J, Bzowska M, Nogiec A, Sroka A, Zarebski M, Vallieres L, Guzik K

Rapid externalization of 27-kDa heat shock protein (HSP27) and atypical cell death in neutrophils treated with the sphingolipid analog drug FTY720

Journal Article

J Leukoc Biol, 98 (4), 2015.

Abstract | Links:

Bozoyan L, Dumas A, Patenaude A, Vallieres L

Interleukin-36γ is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis

Journal Article

J Neuroinflammation, 12 , 2015.

Abstract | Links:

Clarner T, Janssen K, Nellessen L, Stangel M, Skripuletz T, Krauspe B, Hess FM, Denecke B, Beutner C, Linnartz-Gerlach B, Neumann H, Vallieres L, Amor S, Ohl K, Tenbrock K, Beyer C, Kipp M

CXCL10 triggers early microglial activation in the cuprizone model

Journal Article

J Immunol, 194 (7), 2015.

Abstract | Links:

Audoy-Remus J, Bozoyan L, Dumas A, Filali M, Lecours C, Lacroix S, Rivest S, Tremblay ME, Vallieres L

GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease

Journal Article

Brain Behav Immun, 46 , 2015.

Abstract | Links:

Dumas A, Amiable N, de Rivero Vaccari JP, Chae JJ, Keane RW, Lacroix S, Vallieres L

The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis

Journal Article

PLoS Pathog, 10 (5), 2014.

Abstract | Links:

Perez CJ, Dumas A, Vallieres L, Guenet JL, Benavides F

Several classical mouse inbred strains, including DBA/2, NOD/Lt, FVB/N, and SJL/J, carry a putative loss-of-function allele of Gpr84

Journal Article

J Hered, 104 (4), 2013.

Abstract | Links:

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Active projects

  • Autoantibodies and antibody-producing cells in neurological autoimmune diseases: from biology to therapeutic targeting, from 2023-10-01 to 2028-09-30
  • endMS National Education and Training Program: Summer School and SPRINT, from 2023-06-15 to 2026-06-14
  • Mécanisme d’action d’ASPRV1 dans l’inflammation, from 2021-04-01 to 2026-03-31

Recently finished projects

  • 16th Congress of the International Society of Neuroimmunology (ISNI 2023), from 2022-06-01 to 2023-05-31
  • Dual function of autoantibodies in a model of multiple sclerosis, from 2023-03-01 to 2024-02-29
  • Plate-forme de production de nanoparticules lipidiques pour le développement de thérapies à base d'acides nucléiques, from 2022-03-22 to 2023-09-28
  • Suppression of regulatory B cells by neutrophils in a model of multiple sclerosis, from 2018-10-01 to 2023-03-31
Data provided by the Université Laval research projects registery