Dr. Ze Zhang received his B.Eng. and M.Eng. in 1982 and 1984 from Chengdu University of Science & Technology (now Sichuan University) and then his PhD degree in Experimental Medicine from Laval University in 1993. After a postdoctoral training in Japan, he returned to Laval University in 1995 and later became a professor in the Department of Surgery of the School of Medicine, and a researcher at the CHU de Québec-Laval University Research Center Division of Regenerative Medicine. Dr. Zhang’s research has been funded by the Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council of Canada (NSERC), Fonds de la recherche en santé du Québec (FRSQ), and industrial partners. He has more than one hundred journal publications, has edited one book, and authored several book chapters.
Dr. Zhang is interested in biomaterials, wound healing, and cardiovascular devices.
Electrical stimulation for wound healing
Electrical interactions are ubiquitous in biological systems and play pivotal roles in molecular recognition and signal transduction. In collaboration with Dr. Mahmoud Rouabhia, Dr. Zhang develops electrically conductive biomaterials and uses them as scaffold or substrate to mediate electrical stimulation to cells. The electrically activated cells are studied for their behaviors, activation mechanisms, and potential in wound healing. Research approaches include material preparation, cell culture, biological analysis, and animal experiments.
Electrically conductive polymers are useful as semi-conductors and in the energy harvesting and storage sectors. However, such polymers are usually poor in mechanical properties, processability and functionality. Dr. Zhang’s lab focusses on the nano-structured conductive polymers with improved properties and functionalities. Research approaches include polymer synthesis, surface modification, and material analysis.
Cardiovascular devices, implants, and materials
The safety and quality of cardiovascular implants such as vascular prostheses and heart valves are critical to patients. In collaboration with Drs. Yvan Douville and Robert Guidoin, Dr. Zhang has a long-term research interest in the development of new cardiovascular devices, the analysis of clinically retrieved medical explants, and the study of new materials for medical applications. Research approaches include in vitro tests, animal experiments, material analysis, and polymer synthesis.
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Electrical stimulation promotes the proliferation of human keratinocytes, increases the production of keratin 5 and 14, and increases the phosphorylation of ERK1/2 and p38 MAP kinases.Journal Article
J Tissue Eng Regen Med, 14 (7), pp. 909-919, 2020, ISSN: 1932-6254.
Limb salvage after aneurysmal degeneration of a cryopreserved vein allograft: Searching the autologous veins of the arm is worth the effort.Journal Article
Morphologie, 2020, ISSN: 1286-0115.
Comparison of tensile properties of xenopericardium from three animal species and finite element analysis for bioprosthetic heart valve tissue.Journal Article
Artif Organs, 44 (3), pp. 278-287, 2020, ISSN: 0160-564X.
Long-term anticoagulation and selective cells adhesion surface via combination of covalent grafting and layer by layer assembly.Journal Article
Biomed Mater, 14 (6), pp. 065012, 2019, ISSN: 1748-6041.
Donkey pericardium compares favorably with commercial xenopericardia used in the manufacture of transcatheter heart valves.Journal Article
Artif Organs, 43 (10), pp. 976-987, 2019, ISSN: 0160-564X.
Antimicrobial peptides Pep19-2.5 and Pep19-4LF inhibit Streptococcus mutans growth and biofilm formation.Journal Article
Microb Pathog, 133 , pp. 103546, 2019, ISSN: 0882-4010.
The Red Kangaroo pericardium as a material source for the manufacture of percutaneous heart valves.Journal Article
Morphologie, 103 (341), pp. 37-47, 2019, ISSN: 1286-0115.
Toward endothelialization via vascular endothelial growth factor immobilization on cell-repelling functional polyurethanes.Journal Article
J Biomed Mater Res B Appl Biomater, 107 (4), pp. 965-977, 2019, ISSN: 1552-4973.
Surface modification by assembling: a modular approach based on the match in nanostructuresJournal Article
J Mater Chem B Mater Biol Med, 7 (5), pp. 755-762, 2019, ISSN: 2050-750X.
Laser Fenestration of Aortic Stent-Grafts Followed by Noncompliant vs Cutting Balloon Dilation: A Scanning Electron Microscopy Study.Journal Article
J Endovasc Ther, 25 (3), pp. 397-407, 2018, ISSN: 1526-6028.
- Cell Response and Wound Healing Through Electrical Stimulation Mediated by Conductive Scaffold, Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-07-01 to 2021-06-30
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Centre de recherche sur les systèmes polymères et composites à haute performance (CREPEC), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2015-04-01 to 2021-03-31
- Flexible conductive polymer membranes, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2017-04-01 to 2022-03-31