Yves Tremblay is a full professor at Laval University in the Department of Obstetrics, Gynecology & Reproduction, and a senior scientist at the CHU de Québec-Laval University Research Center. He obtained his bachelor’s degree in 1979 and his PhD in physiology and molecular endocrinology in 1984 from Laval University’s School of Medicine. From 1985-1990, he pursued three post- doctoral training programs at the Louis-Pasteur University in Strasbourg, France on steroid receptor molecular biology, at the University of Montreal on molecular biology of the endocrine systems, and at the University of California in San Francisco in the Department of Pediatrics, on molecular biology of human steroidogenic enzymes. He is the co-founder of the eBook strategic initiative that uses the Web-based discussion forum to approach the delicate question of being born too soon. Between 2005 and 2011, he was member of the Institute Advisory Board of the Institute of Gender and Health from the Canadian Institutes of Health Research. Between 2011 and 2015, he was the Director for the Respiratory Health Network from the Fonds de Recherche Québec en Santé. Meanwhile, he was also a member, and then President of the Board of Directors of the Quebec Lung Association. Since August 2015, he has been the President of the International and Interdisciplinary Association on the Pharmaceutical Life Cycle. He has also served over the last 20 years on several provincial, national, and international committees.
For over 25 years, the development of Dr. Tremblay’s research expertise has been directly related to fetal development and gene expression of the steroidogenesis-specific enzymes involved in the metabolism of steroid hormones in gonads, adrenals, and peripheral tissues, including both placenta and fetal lungs. Androgens synthesized by the fetal lungs, estradiol synthesized by the placenta, and regulation of the fetal lungs by glucocorticoids do control key events in fetal development by means of their cell-type specific expression, temporal regulation, and regionalization in their presence and action; in all cases, a disruption in the metabolism and problems associated with the action of androgens and estrogens during pregnancy and a deregulation of glucocorticoid in the fetal lungs is directly related to developmental syndrome and pathologies, namely respiratory distress syndrome and bronchopulmonary dysplasia disease. This research presents specific aspects that hold potential for clinical applications: studying the metabolism and regulation of steroid hormones by the lungs is applicable to many sectors of physiology, including modelization, while their action on fetal development, and, more specifically, lung maturation and development, has clinical potential in human health. More recently, our research on lung development in early life has indicated a potential interest for emphysema, a disease for which we have no curative treatment.
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Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20α-hydroxysteroid dehydrogenase in the mouse lung.Journal Article
BMC Res Notes, 7 , pp. 119, 2014.
Identification of most stable endogenous control genes for microRNA quantification in the developing mouse lung.Journal Article
PLoS ONE, 9 (11), pp. e111855, 2014.
Glucocorticoid metabolism in the developing lung: adrenal-like synthesis pathway.Journal Article
J Steroid Biochem Mol Biol, 138 , pp. 72-80, 2013, ISSN: 0960-0760.
Major enzymes controlling the androgenic pressure in the developing lung.Journal Article
J Steroid Biochem Mol Biol, 137 , pp. 93-8, 2013, ISSN: 0960-0760.
Androgens in the maternal and fetal circulation: association with insulin resistance.Journal Article
J Matern Fetal Neonatal Med, 26 (5), pp. 513-9, 2013, ISSN: 1476-7058.
Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs.Journal Article
J Allergy Clin Immunol, 130 (5), pp. 1049-62, 2012, ISSN: 0091-6749.
Sex-specific perinatal expression of glutathione peroxidases during mouse lung development.Journal Article
Mol Cell Endocrinol, 355 (1), pp. 87-95, 2012, ISSN: 0303-7207.
Role of gender in morbidity and mortality of extremely premature neonates.Journal Article
Am J Perinatol, 29 (3), pp. 159-66, 2012, ISSN: 0735-1631.
L’influence de Mars et Vénus sur le développement pulmonaire : implications en recherche biomédicale et au-delàBook Chapter
de la santé des femmes et des hommes. de recherche en santé du Canada, Institut Instituts (Ed.): L'influence du genre et du sexe, un recueil de cas sur la recherche liée au genre, au sexe et à la santé, pp. 9-18, Vancouver, BC, Instituts de recherche en santé du Canada, 2012, ISBN: 9781100979212 (français) / 9781100192505 (anglais).
The influence of Mars and Venus on lung development: implications for biomedical research and beyondBook Chapter
of Gender, Institute; of Research, Health. Canadian Institutes Health (Ed.): What a difference sex and gender make a gender, sex and health research casebook, pp. 8-16, Vancouver, BC, Institute of Gender and Health of the Canadian Institutes of Health Research, 2012, ISBN: 9781100192505 (anglais) / 9781100979212 (français).
- A Pre-Clinical Research for Treatment of Prematurity and BronchoPulmonary Dysplasia through Intracrinology, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-10-01 to 2021-09-30
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Centre de recherche en reproduction, développement et santé intergénérationnelle, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2021-04-30
- Steroid hormone synthesis/inactivation and action in terminal lung development., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2016-04-01 to 2021-03-31
Recently finished projects
- Effet des androgènes sur la santé pulmonaire des nouveaux-nés , Subvention, Fondation du CHU de Québec, from 2018-04-17 to 2019-03-31