Yves Tremblay is a full professor at Laval University in the Department of Obstetrics, Gynecology & Reproduction, and a senior scientist at the CHU de Québec-Laval University Research Center. He obtained his bachelor’s degree in 1979 and his PhD in physiology and molecular endocrinology in 1984 from Laval University’s School of Medicine. From 1985-1990, he pursued three post- doctoral training programs at the Louis-Pasteur University in Strasbourg, France on steroid receptor molecular biology, at the University of Montreal on molecular biology of the endocrine systems, and at the University of California in San Francisco in the Department of Pediatrics, on molecular biology of human steroidogenic enzymes. He is the co-founder of the eBook strategic initiative that uses the Web-based discussion forum to approach the delicate question of being born too soon. Between 2005 and 2011, he was member of the Institute Advisory Board of the Institute of Gender and Health from the Canadian Institutes of Health Research. Between 2011 and 2015, he was the Director for the Respiratory Health Network from the Fonds de Recherche Québec en Santé. Meanwhile, he was also a member, and then President of the Board of Directors of the Quebec Lung Association. Since August 2015, he has been the President of the International and Interdisciplinary Association on the Pharmaceutical Life Cycle. He has also served over the last 20 years on several provincial, national, and international committees.
For over 25 years, the development of Dr. Tremblay’s research expertise has been directly related to fetal development and gene expression of the steroidogenesis-specific enzymes involved in the metabolism of steroid hormones in gonads, adrenals, and peripheral tissues, including both placenta and fetal lungs. Androgens synthesized by the fetal lungs, estradiol synthesized by the placenta, and regulation of the fetal lungs by glucocorticoids do control key events in fetal development by means of their cell-type specific expression, temporal regulation, and regionalization in their presence and action; in all cases, a disruption in the metabolism and problems associated with the action of androgens and estrogens during pregnancy and a deregulation of glucocorticoid in the fetal lungs is directly related to developmental syndrome and pathologies, namely respiratory distress syndrome and bronchopulmonary dysplasia disease. This research presents specific aspects that hold potential for clinical applications: studying the metabolism and regulation of steroid hormones by the lungs is applicable to many sectors of physiology, including modelization, while their action on fetal development, and, more specifically, lung maturation and development, has clinical potential in human health. More recently, our research on lung development in early life has indicated a potential interest for emphysema, a disease for which we have no curative treatment.
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Essential Intracrine Androgenic Action in Lung Development for Both Sexes.Journal Article
J Steroid Biochem Mol Biol, 183 , pp. 184-191, 2018, ISSN: 0960-0760.
Prenatal exposure to an environmentally relevant mixture of Canadian Arctic contaminants decreases male reproductive function in an aging rat model.Journal Article
J Dev Orig Health Dis, 9 (5), pp. 511-518, 2018, ISSN: 2040-1744.
[Morphometry of pulmonary tissue: From manual to high throughput automation].Journal Article
Rev Mal Respir, 34 (10), pp. 1072-1084, 2017, ISSN: 0761-8425.
Personalized Medicine: Interdisciplinary Perspective, World Tidal Wave, and Potential Growth for the Emerging CountriesBook Chapter
Verma, M; Barh, D (Ed.): Progress and Challenges in Precision Medicine, pp. 301-314, London, UK, Academic Press , 2017, ISBN: 978-0-12-809411-2.
Dynamic modulation of Cyp21a1 (21-hydroxylase) expression sites in the mouse developing lung.Journal Article
J Steroid Biochem Mol Biol, 168 , pp. 102-109, 2017, ISSN: 0960-0760.
CYP21A2 expression is localized in the developing distal epithelium of the human perinatal lung and is compatible with in situ production and intracrine actions of active glucocorticoids.Journal Article
J Steroid Biochem Mol Biol, 163 , pp. 12-9, 2016, ISSN: 0960-0760.
Expression profile of androgen-modulated microRNAs in the fetal murine lung.Journal Article
Biol Sex Differ, 7 , pp. 20, 2016, ISSN: 2042-6410.
Automated High-Performance Analysis of Lung Morphometry.Journal Article
Am J Respir Cell Mol Biol, 53 (2), pp. 149-58, 2015, ISSN: 1044-1549.
C21-steroids inactivation and glucocorticoid synthesis in the developing lung.Journal Article
J Steroid Biochem Mol Biol, 147 , pp. 70-80, 2015, ISSN: 0960-0760.
A transdisciplinary approach to the decision-making process in extreme prematurity.Journal Article
BMC Res Notes, 7 , pp. 450, 2014.
- A Pre-Clinical Research for Treatment of Prematurity and BronchoPulmonary Dysplasia through Intracrinology, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-10-01 to 2021-09-30
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Centre de recherche en reproduction, développement et santé intergénérationnelle, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2021-04-30
- Steroid hormone synthesis/inactivation and action in terminal lung development., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2016-04-01 to 2021-03-31
Recently finished projects
- Effet des androgènes sur la santé pulmonaire des nouveaux-nés , Subvention, Fondation du CHU de Québec, from 2018-04-17 to 2019-03-31