Dr. Vincent Pernet has been Assistant Professor in the Department of Ophthalmology at Laval University since 2014. His research focuses on the mechanisms of plasticity and neuronal degeneration in diseases such as glaucoma and diabetic retinopathy, as well as occurring during normal and pathological aging of the visual system.

Enabling the plasticity of visual neurons

With his team, he is interested in molecules likely to alter the functioning of retinal cells, such as the Nogo-A neuronal plasticity inhibitory protein, the proteins involved in Alzheimer’s disease (amyloid and Tau) and the CNTF-Stat3 pathway that governs neuronal growth. Dr. Pernet has demonstrated the important role of the Nogo-A protein in inhibiting the regeneration of the injured optic nerve, and in the plasticity of the visual system, intact or injured. Neutralization of Nogo-A strongly increases neuronal plasticity and visual recovery in ocular disease models. Recently, his team discovered that neutralizing Nogo-A with a blocking antibody also improves vascular repair and retinal function in a proliferative retinopathy model. These results suggest that Nogo-A may be a therapeutic target to restore normal retinal vasculature, and protect the eyesight of patients suffering from diabetic retinopathy or retinopathy of prematurity. Tests are underway to determine the effects of Nogo-A in diabetic retinopathy and glaucoma.

Reducing the effects of normal and pathological aging of the retina

The aging of the visual system is characterized by a decline in retinal function, which can be followed using electroretinographic measurements. The molecular mechanisms responsible for the loss of activity in the eye’s neurons are not known. Dr. Pernet’s lab is trying to identify the factors that influence the observed reorganization of neuronal connections in the retinas of old animals. Ultimately, the results of this work could be used to stimulate functional reconnection of circuits in the aging retina.

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Joly S, Pernet V, Chemtob S, Di Polo A, Lachapelle P

Neuroprotection in the juvenile rat model of light-induced retinopathy: evidence suggesting a role for FGF-2 and CNTF.

Journal Article

Invest Ophthalmol Vis Sci, 48 (5), pp. 2311-20, 2007, ISSN: 0146-0404.

Abstract | Links:

Joly S, Pernet V, Dorfman AL, Chemtob S, Lachapelle P

Light-induced retinopathy: comparing adult and juvenile rats.

Journal Article

Invest Ophthalmol Vis Sci, 47 (7), pp. 3202-12, 2006, ISSN: 0146-0404.

Abstract | Links:

Pernet V, Di Polo A

Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo.

Journal Article

Brain, 129 (Pt 4), pp. 1014-26, 2006, ISSN: 0006-8950.

Abstract | Links:

Gauthier R, Joly S, Pernet V, Lachapelle P, Di Polo A

Brain-derived neurotrophic factor gene delivery to muller glia preserves structure and function of light-damaged photoreceptors.

Journal Article

Invest Ophthalmol Vis Sci, 46 (9), pp. 3383-92, 2005, ISSN: 0146-0404.

Abstract | Links:

Zhou Y, Pernet V, Hauswirth WW, Di Polo A

Activation of the extracellular signal-regulated kinase 1/2 pathway by AAV gene transfer protects retinal ganglion cells in glaucoma.

Journal Article

Mol Ther, 12 (3), pp. 402-12, 2005, ISSN: 1525-0016.

Abstract | Links:

Pernet V, Hauswirth WW, Di Polo A

Extracellular signal-regulated kinase 1/2 mediates survival, but not axon regeneration, of adult injured central nervous system neurons in vivo.

Journal Article

J Neurochem, 93 (1), pp. 72-83, 2005, ISSN: 0022-3042.

Abstract | Links:

Pernet V, Anctil M, Grimmelikhuijzen CJ

Antho-RFamide-containing neurons in the primitive nervous system of the anthozoan Renilla koellikeri.

Journal Article

J Comp Neurol, 472 (2), pp. 208-20, 2004, ISSN: 0021-9967.

Abstract | Links:

Pernet V, Anctil M

Annual variations and sex-related differences of estradiol-17beta levels in the anthozoan Renilla koellikeri.

Journal Article

Gen Comp Endocrinol, 129 (1), pp. 63-8, 2002, ISSN: 0016-6480.

Abstract | Links:

Pernet V, Gavino V, Gavino G, Anctil M

Variations of lipid and fatty acid contents during the reproductive cycle of the anthozoan Renilla koellikeri.

Journal Article

J Comp Physiol [B], 172 (6), pp. 455-65, 2002, ISSN: 0174-1578.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2023-05-01
  • Études des mécanismes de plasticité vasculaire et neuronale dans les maladies de la rétine, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2018-07-01 to 2022-06-30
  • Mécanismes moléculaires contrôlant le développement des cellules de Müller de la rétine et leurs effets sur l’angiogenèse., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2015-04-01 to 2021-03-31
  • Mechanisms of neuronal and vascular impairments in ischemic retinopathies, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-04-01 to 2024-03-31

Recently finished projects

  • The inhibition of Nogo-A by gene therapy as a new treatment for glaucoma, Subvention, Velux Stiftung, from 2016-02-01 to 2019-06-30
Data provided by the Université Laval research projects registery