Dr. Vincent Pernet has been Assistant Professor in the Department of Ophthalmology at Laval University since 2014. His research focuses on the mechanisms of plasticity and neuronal degeneration in diseases such as glaucoma and diabetic retinopathy, as well as occurring during normal and pathological aging of the visual system.
Enabling the plasticity of visual neurons
With his team, he is interested in molecules likely to alter the functioning of retinal cells, such as the Nogo-A neuronal plasticity inhibitory protein, the proteins involved in Alzheimer’s disease (amyloid and Tau) and the CNTF-Stat3 pathway that governs neuronal growth. Dr. Pernet has demonstrated the important role of the Nogo-A protein in inhibiting the regeneration of the injured optic nerve, and in the plasticity of the visual system, intact or injured. Neutralization of Nogo-A strongly increases neuronal plasticity and visual recovery in ocular disease models. Recently, his team discovered that neutralizing Nogo-A with a blocking antibody also improves vascular repair and retinal function in a proliferative retinopathy model. These results suggest that Nogo-A may be a therapeutic target to restore normal retinal vasculature, and protect the eyesight of patients suffering from diabetic retinopathy or retinopathy of prematurity. Tests are underway to determine the effects of Nogo-A in diabetic retinopathy and glaucoma.
Reducing the effects of normal and pathological aging of the retina
The aging of the visual system is characterized by a decline in retinal function, which can be followed using electroretinographic measurements. The molecular mechanisms responsible for the loss of activity in the eye’s neurons are not known. Dr. Pernet’s lab is trying to identify the factors that influence the observed reorganization of neuronal connections in the retinas of old animals. Ultimately, the results of this work could be used to stimulate functional reconnection of circuits in the aging retina.
- Canet, GeoffreyPostdoctoral fellowCHULgeoffrey.email@example.com
2705, boul. Laurier, bur. P-9703
Canada G1V 4G2
- Mdzomba, Julius BayaDoctoral studentCHUL+1 418-525-4444, extension firstname.lastname@example.org@ulaval.ca
2705, Boul. Laurier
Canada G1V 4G2
- Rodriguez, LéaDoctoral studentCHUL+1 418-525-4444, extension email@example.com@ulaval.ca
2705 boulevard Laurier
Canada G1V 4G2
Optic nerve regeneration in mammals: Regenerated or spared axons?Journal Article
Exp Neurol, 296 , pp. 83-88, 2017, ISSN: 0014-4886.
Sphingosine 1-Phosphate Receptor 1 Modulates CNTF-Induced Axonal Growth and Neuroprotection in the Mouse Visual System.Journal Article
Neural Plast, 2017 , pp. 6818970, 2017.
Reticulon 4A/Nogo-A influences the distribution of Kir4.1 but is not essential for potassium conductance in retinal Müller glia.Journal Article
Neurosci Lett, 627 , pp. 168-77, 2016, ISSN: 0304-3940.
Nogo-A deletion increases the plasticity of the optokinetic response and changes retinal projection organization in the adult mouse visual system.Journal Article
Brain Struct Funct, 221 (1), pp. 317-29, 2016, ISSN: 1863-2653.
Sphingosine 1-phosphate receptor 1 is required for retinal ganglion cell survival after optic nerve trauma.Journal Article
J Neurochem, 138 (4), pp. 571-86, 2016, ISSN: 0022-3042.
Cell type-specific Nogo-A gene ablation promotes axonal regeneration in the injured adult optic nerve.Journal Article
Cell Death Differ, 22 (2), pp. 323-35, 2015, ISSN: 1350-9047.
The Ephrin receptor EphA4 restricts axonal sprouting and enhances branching in the injured mouse optic nerve.Journal Article
Eur J Neurosci, 40 (7), pp. 3021-31, 2014, ISSN: 0953-816X.
Lost in the jungle: new hurdles for optic nerve axon regeneration.Journal Article
Trends Neurosci, 37 (7), pp. 381-7, 2014, ISSN: 0166-2236.
New mouse retinal stroke model reveals direction-selective circuit damage linked to permanent optokinetic response loss.Journal Article
Invest Ophthalmol Vis Sci, 55 (7), pp. 4476-89, 2014, ISSN: 0146-0404.
Calsyntenin-1 regulates targeting of dendritic NMDA receptors and dendritic spine maturation in CA1 hippocampal pyramidal cells during postnatal development.Journal Article
J Neurosci, 34 (26), pp. 8716-27, 2014, ISSN: 0270-6474.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2023-05-01
- Études des mécanismes de plasticité vasculaire et neuronale dans les maladies de la rétine, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2018-07-01 to 2022-06-30
- Mécanismes moléculaires contrôlant le développement des cellules de Müller de la rétine et leurs effets sur l’angiogenèse., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2015-04-01 to 2021-03-31
Recently finished projects
- The inhibition of Nogo-A by gene therapy as a new treatment for glaucoma, Subvention, Velux Stiftung, from 2016-02-01 to 2019-06-30