Dr. Vincent Pernet has been Assistant Professor in the Department of Ophthalmology at Laval University since 2014. His research focuses on the mechanisms of plasticity and neuronal degeneration in diseases such as glaucoma and diabetic retinopathy, as well as occurring during normal and pathological aging of the visual system.
Enabling the plasticity of visual neurons
With his team, he is interested in molecules likely to alter the functioning of retinal cells, such as the Nogo-A neuronal plasticity inhibitory protein, the proteins involved in Alzheimer’s disease (amyloid and Tau) and the CNTF-Stat3 pathway that governs neuronal growth. Dr. Pernet has demonstrated the important role of the Nogo-A protein in inhibiting the regeneration of the injured optic nerve, and in the plasticity of the visual system, intact or injured. Neutralization of Nogo-A strongly increases neuronal plasticity and visual recovery in ocular disease models. Recently, his team discovered that neutralizing Nogo-A with a blocking antibody also improves vascular repair and retinal function in a proliferative retinopathy model. These results suggest that Nogo-A may be a therapeutic target to restore normal retinal vasculature, and protect the eyesight of patients suffering from diabetic retinopathy or retinopathy of prematurity. Tests are underway to determine the effects of Nogo-A in diabetic retinopathy and glaucoma.
Reducing the effects of normal and pathological aging of the retina
The aging of the visual system is characterized by a decline in retinal function, which can be followed using electroretinographic measurements. The molecular mechanisms responsible for the loss of activity in the eye’s neurons are not known. Dr. Pernet’s lab is trying to identify the factors that influence the observed reorganization of neuronal connections in the retinas of old animals. Ultimately, the results of this work could be used to stimulate functional reconnection of circuits in the aging retina.
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- Mdzomba, Julius BayaDoctoral studentCHUL+1 418-525-4444, extension email@example.com@ulaval.ca
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- Rodriguez, LéaDoctoral studentCHUL+1 418-525-4444, extension firstname.lastname@example.org@ulaval.ca
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- Wong Chong, ÉmilieDoctoral studentCHUL+1 418-252-4444, extension email@example.com
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Tau modulates visual plasticity in adult and old mice.Journal Article
Neurobiol Aging, 95 , pp. 214-224, 2020, ISSN: 0197-4580.
Tau Gene Deletion does not Influence Axonal Regeneration and Retinal Neuron Survival in the Injured Mouse Visual System.Journal Article
Int J Mol Sci, 21 (11), 2020.
Nogo-A-targeting antibody promotes visual recovery and inhibits neuroinflammation after retinal injury.Journal Article
Cell Death Dis, 11 (2), pp. 101, 2020.
Synthesis of Ultrastable Gold Nanoparticles as a New Drug Delivery System.Journal Article
Molecules, 24 (16), 2019.
Nogo-A inactivation improves visual plasticity and recovery after retinal injury.Journal Article
Cell Death Dis, 9 (7), pp. 727, 2018.
Nogo-A inhibits vascular regeneration in ischemic retinopathy.Journal Article
Glia, 66 (10), pp. 2079-2093, 2018, ISSN: 0894-1491.
Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons.Journal Article
Front Mol Neurosci, 11 , pp. 293, 2018.
Corrigendum: Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons.Journal Article
Front Mol Neurosci, 11 , pp. 390, 2018.
Nonamyloidogenic processing of amyloid beta precursor protein is associated with retinal function improvement in aging male APPswe/PS1ΔE9 mice.Journal Article
Neurobiol Aging, 53 , pp. 181-191, 2017, ISSN: 0197-4580.
Nogo-A in the visual system development and in ocular diseases.Journal Article
Biochim Biophys Acta, 1863 (6), pp. 1300-1311, 2017, ISSN: 0006-3002.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2023-05-01
- Études des mécanismes de plasticité vasculaire et neuronale dans les maladies de la rétine, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2018-07-01 to 2022-06-30
- Mécanismes moléculaires contrôlant le développement des cellules de Müller de la rétine et leurs effets sur l’angiogenèse., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2015-04-01 to 2021-03-31
Recently finished projects
- The inhibition of Nogo-A by gene therapy as a new treatment for glaucoma, Subvention, Velux Stiftung, from 2016-02-01 to 2019-06-30