Dr. Vincent Fradet (MD, PhD, FRCSC) is an uro-oncologist with a focused clinical practice at CHU de Québec-Laval University. He completed his medical training at Université de Montréal with an MD and residency in urology. He pursued with 5 years of subspecialty and research training. He obtained his uro-oncology accreditation from the Society of Urologic Oncology at the University of California, in San Francisco (UCSF) and completed a PhD in Clinical Research/Epidemiolgy (University de Montréal). Dr. Fradet has been an Associate Professor at Laval University since 2009, and is a regular researcher at the Laval University Cancer Research Center and at INAF (Institute for Nutrition and functional Food).

Dr. Fradet’s research goal is to improve our understanding of the links between lifestyle factors, including dietary omega-3 fatty acids and exercise, quality of life parameters, inflammation, and oncogenic pathways in prostate cancer, to progressively develop personalized preventive and treatment strategies. To that end, Dr. Fradet has built a unique biobank of bio-samples, developed pre-clinical models (mouse and primary cells in culture) and is running some clinical studies. All the epidemiological, clinical, and molecular (translational) projects led by his team are focused on improving our understanding of the biological mechanisms and the impact on quality of life of prostate cancer, as well as on developing biomarkers (urinary, blood, epigenetics, molecular and/or cellular) to be used in future intervention studies to stratify or select and monitor patients.

L'Hôtel-Dieu de Québec
6, rue McMahon
0622
Québec, Québec
Canada G1R 2J6
+1 418-525-4444, extension 15568
+1 418-691-5562

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Haider M, Ladurner C, Mayr R, Tandogdu Z, Fritsche HM, Fradet V, Comploj E, Pycha A, Lemire F, Lacombe L, Fradet Y, Toren P, Lodde M

Use and duration of antibiotic prophylaxis and the rate of urinary tract infection after radical cystectomy for bladder cancer: Results of a multicentric series.

Journal Article

Urol Oncol, 2019, ISSN: 1078-1439.

Abstract | Links:

Gevariya N, Besancon M, Robitaille K, Picard V, Diabate L, Alesawi A, Julien P, Fradet Y, Bergeron A, Fradet V

Omega-3 fatty acids decrease prostate cancer progression associated with an anti-tumor immune response in eugonadal and castrated mice.

Journal Article

Prostate, 79 (1), pp. 9-20, 2019, ISSN: 0270-4137.

Abstract | Links:

Lavallee E, Bergeron M, Buteau FA, Blouin AC, Duchesnay N, Dujardin T, Tiguert R, Lacombe L, Fradet V, Makao-Nguile M, Fradet Y, Beauregard JM, Pouliot F

Increased Prostate Cancer Glucose Metabolism Detected by 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Localised Gleason 8-10 Prostate Cancers Identifies Very High-risk Patients for Early Recurrence and Resistance to Castration.

Journal Article

Eur Urol Focus, 2018.

Abstract | Links:

Theriault B, Marceau-Grimard M, Blais AS, Fradet V, Moore K, Cloutier J

Urology residents on call: Investigating the workload and relevance of calls.

Journal Article

Can Urol Assoc J, 12 (2), pp. E71-E75, 2018, ISSN: 1911-6470.

Abstract | Links:

Guertin MH, Robitaille K, Pelletier JF, Duchesne T, Julien P, Savard J, Bairati I, Fradet V

Effects of concentrated long-chain omega-3 polyunsaturated fatty acid supplementation before radical prostatectomy on prostate cancer proliferation, inflammation, and quality of life: study protocol for a phase IIb, randomized, double-blind, placebo-controlled trial.

Journal Article

BMC Cancer, 18 (1), pp. 64, 2018.

Abstract | Links:

Fradet V, Toren P, Nguile-Makao M, Lodde M, Levesque J, Leger C, Caron A, Bergeron A, Ben-Zvi T, Lacombe L, Pouliot F, Tiguert R, Dujardin T, Fradet Y

Prognostic value of urinary prostate cancer antigen 3 (PCA3) during active surveillance of patients with low-risk prostate cancer receiving 5α-reductase inhibitors.

Journal Article

BJU Int, 121 (3), pp. 399-404, 2018, ISSN: 1464-4096.

Abstract | Links:

Vigneault E, Savard J, Savard MH, Ivers H, Despres P, Foster W, Martin AG, Fradet V

Validation of the French-Canadian version of the Expanded Prostate Cancer Index Composite (EPIC) in a French-Canadian population.

Journal Article

Can Urol Assoc J, 11 (12), pp. 404-410, 2017, ISSN: 1911-6470.

Abstract | Links:

Allaire J, Ben-Zvi T, Lamarche B, Robitaille K, Fradet Y, Lacombe L, Fradet V

Preoperative nutritional factors and outcomes after radical cystectomy: A narrative review.

Journal Article

Can Urol Assoc J, 11 (12), pp. 419-424, 2017, ISSN: 1911-6470.

Abstract | Links:

Allaire J, Leger C, Ben-Zvi T, Nguile-Makao M, Fradet Y, Lacombe L, Fradet V

Prospective Evaluation of Nutritional Factors to Predict the Risk of Complications for Patients Undergoing Radical Cystectomy: A Cohort Study.

Journal Article

Nutr Cancer, 69 (8), pp. 1196-1204, 2017, ISSN: 0163-5581.

Abstract | Links:

Morin F, Beauregard JM, Bergeron M, Nguile Makao M, Lacombe L, Fradet V, Fradet Y, Pouliot F

Metabolic Imaging of Prostate Cancer Reveals Intrapatient Intermetastasis Response Heterogeneity to Systemic Therapy.

Journal Article

Eur Urol Focus, 3 (6), pp. 639-642, 2017.

Abstract | Links:

29 entries « ‹ 1 of 3 › »
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Active projects

  • (FRSQ 82584)Soutien du projet de recherche pour le cancer de la prostate, Subvention, Fondation du CHU de Québec, from 2018-09-13 to 2019-03-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2023-04-30
  • Centre hospitalier universitaire de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Détresse et satisfactions face au processus informationnel et décisionnel lors d'un cancer de la prostate localisé, Subvention, Fondation de l'Université Laval, from 2017-02-01 to 2020-03-31
  • Impact of microbiota on prostate cancer: from gut to tumor microenvironment., Subvention, Centre hospitalier universitaire de Montréal, from 2018-12-01 to 2019-12-31
  • Institut sur la nutrition et les aliments fonctionnels (INAF), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2017-04-01 to 2023-03-31
  • Interaction between environment, diet, physical activities, and sexual habits, in the risk of prostate cancer. Validation of biomarkers to personnalize preventive interventions., Subvention, Société de recherche sur le cancer, Compétition GRePEC (SRC/FRSQ/MDEIE), from 2012-10-01 to 2019-08-31
  • Prebiotics to enhance immunotherapy response in bladder cancer, Subvention, The W. Garfield Weston Foundation, 2018 Proof-of-Principle Grant Call, from 2019-01-01 to 2020-07-31
  • Rôle du microbiote intestinal dans le cancer de la prostate, Subvention, Université Laval - Soutien à la recherche, from 2018-05-01 to 2019-04-30
  • Role of Gut Microbiota on anti-Inflammatory effect of Omega-3 in Prostate Cancer, Subvention, Cancer de la prostate Canada, Subventions d'équipe Movember (Movember Discovery Grants), from 2016-04-01 to 2019-03-31
  • Toward nutritional and epigenomic interventions in prostate cancer prevention and management, Subvention, Instituts de recherche en santé du Canada, Fonctionnement: Subvention de promotion de l’impact - CCREES, from 2017-10-01 to 2020-09-30

Recently finished projects

  • (FRQS 74055) Instaurer une plateforme de saisie de données médicales des patients atteints d'un cancer de la prostate hormonorésistant. Cancer prostate avance - soutient patients - HDQ, Subvention, Fondation du CHU de Québec, from 2016-08-03 to 2017-08-02
  • (FRSQ 73897) Fonctionnement de la plateforme méthodologique du CRCEO (analyses statistiques euro-oncologie), Subvention, CHU de Qc–UL- Hôpital Hôtel-Dieu-de-Québec, from 2016-04-07 to 2017-04-06
  • (FRSQ 74055-2)Instaurer une plateforme de saisie de données médicales des patients atteints d'un cancer de la prostate hormonorésistant - phase 2(suite octroi 2713_sirul 115144), Subvention, Fondation du CHU de Québec, from 2017-09-14 to 2018-09-13
  • (FRSQ 76081)Recherche pour le développement d'un pronostic de suivi pour les patients atteints d'un cancer avancé de la prostate, Subvention, Fondation du CHU de Québec, from 2017-01-31 to 2018-01-30
  • (frsq 76128)Plateforme méthodologique du CRCEO en recherche en uro-oncologie (bio-statisticien)Demande d'octroi # 2852, Subvention, Fondation du CHU de Québec, from 2016-12-07 to 2017-12-06
  • (FRSQ 78572)Soutien d'activités d'éducation des étudiants en recherche, Subvention, Fondation du CHU de Québec, from 2017-08-04 to 2018-08-03
  • (FRSQ 78855) recherche clinique pour le cancer de la prostate (acides gras omega 3), Subvention, Fondation du CHU de Québec, from 2017-02-10 to 2018-03-31
  • (FRSQ 80129) Plateforme méthodologique du CRCEO pour supporter les besoins d'analyses statistiques du groupe d'uro-oncologie , Subvention, Fondation du CHU de Québec, from 2017-12-07 to 2018-03-31
  • Carbohydrate antigens-functionalized silver nanoparticles-Toward a fast and sensitive assay for clinical diagnostic of prostate cancer, Subvention, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Réseau de centres d'excellence (RCE), from 2018-01-01 to 2018-12-31
  • Carbohydrate antigens-functionalized silver nanoparticles-Toward a fast and sensitive assay for clinical diagnostic of prostate cancer, Subvention, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Réseau de centres d'excellence (RCE), from 2018-01-01 to 2018-12-31
  • Carbohydrate antigens-functionalized silver nanoparticles-Toward a fast and sensitive assay for clinical diagnostic of prostate cander, Subvention, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Réseau de centres d'excellence (RCE), from 2018-01-01 to 2018-12-31
  • Coordinated chromosome domains enforce the gene expression program of cancer cells., Subvention, L'Institut de recherche de la Société canadienne du cancer, Subventions pour l'innovation, from 2015-08-01 to 2018-07-31
  • Le rôle de la nutrition et de l'inflammation dans la prévention et le traitement du cancer de la prostate., Subvention, Fonds de recherche du Québec - Santé, Chercheurs-boursiers cliniciens - Juniors 1 et 2, Seniors, from 2014-10-01 to 2018-09-30
  • Phase II double-blind randomised controlled trial of concentrated omega-3 (mainly EPA) before prostatectomy evaluating the effects on prostate cancer proliferation, inflammation and quality of life., Subvention, L'Institut de recherche de la Société canadienne du cancer, Subventions pour l'innovation, from 2014-02-01 to 2018-01-31
  • Registre dynamique canadien du cancer de la prostate avancé, Subvention, Fondation du CHU de Québec, from 2013-04-01 to 2018-03-31
  • Tranexamic acid during cystectomy trial (TACT), Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2018-06-30
Data provided by the Université Laval research projects registery