Dr. Vincent Fradet (MD, PhD, FRCSC) is an uro-oncologist with a focused clinical practice at CHU de Québec-Laval University. He completed his medical training at Université de Montréal with an MD and residency in urology. He pursued with 5 years of subspecialty and research training. He obtained his uro-oncology accreditation from the Society of Urologic Oncology at the University of California, in San Francisco (UCSF) and completed a PhD in Clinical Research/Epidemiolgy (University de Montréal). Dr. Fradet has been an Associate Professor at Laval University since 2009, and is a regular researcher at the Laval University Cancer Research Center and at INAF (Institute for Nutrition and functional Food).

Dr. Fradet’s research goal is to improve our understanding of the links between lifestyle factors, including dietary omega-3 fatty acids and exercise, quality of life parameters, inflammation, and oncogenic pathways in prostate cancer, to progressively develop personalized preventive and treatment strategies. To that end, Dr. Fradet has built a unique biobank of bio-samples, developed pre-clinical models (mouse and primary cells in culture) and is running some clinical studies. All the epidemiological, clinical, and molecular (translational) projects led by his team are focused on improving our understanding of the biological mechanisms and the impact on quality of life of prostate cancer, as well as on developing biomarkers (urinary, blood, epigenetics, molecular and/or cellular) to be used in future intervention studies to stratify or select and monitor patients.

L'Hôtel-Dieu de Québec
6, rue McMahon
0622
Québec, Québec
Canada G1R 2J6
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Gevariya N, Lachance G, Robitaille K, Joly Beauparlant C, Beaudoin L, Fournier E, Fradet Y, Droit A, Julien P, Marette A, Bergeron A, Fradet V

Omega-3 Eicosapentaenoic Acid Reduces Prostate Tumor Vascularity.

Journal Article

Mol Cancer Res, 19 (3), pp. 516-527, 2021, ISSN: 1541-7786.

Abstract | Links:

Bilodeau JF, Gevariya N, Larose J, Robitaille K, Roy J, Oger C, Galano JM, Bergeron A, Durand T, Fradet Y, Julien P, Fradet V

Long chain omega-3 fatty acids and their oxidized metabolites are associated with reduced prostate tumor growth.

Journal Article

Prostaglandins Leukot Essent Fatty Acids, 164 , pp. 102215, 2021, ISSN: 0952-3278.

Abstract | Links:

Gotto G, Drachenberg DE, Chin J, Casey R, Fradet V, Sabbagh R, Shayegan B, Rendon RA, Danielson B, Camacho F, Zardan A, Plante R, Hew H, Chan K, Feifer A

Real-world evidence in patient-reported outcomes (PROs) of metastatic castrate-resistant prostate cancer (mCRPC) patients treated with abiraterone acetate + prednisone (AA+P) across Canada: Final results of COSMiC.

Journal Article

Can Urol Assoc J, 14 (12), pp. E616-E620, 2020, ISSN: 1911-6470.

Abstract | Links:

Fervaha G, Izard JP, Tripp DA, Aghel N, Shayegan B, Klotz L, Niazi T, Fradet V, Taussky D, Lavallee LT, Hamilton RJ, Brown I, Chin J, Gopaul D, Violette PD, Davis MK, Karampatos S, Pinthus JH, Leong DP, Biostat M, Siemens DR, RADICAL PC Investigators

Psychological morbidity associated with prostate cancer: Rates and predictors of depression in the RADICAL PC study.

Journal Article

Can Urol Assoc J, 2020, ISSN: 1911-6470.

Abstract | Links:

Koti M, Berman DM, Siemens DR, Lange D, Wang E, Toren P, Eigl BJ, Hardy C, Purves R, Fradet V, Fradet Y, Mansure J, Kassouf W, Black PC, Canadian Bladder Cancer Research Network

Building a Canadian Translational Bladder Cancer Research Network.

Journal Article

Can Urol Assoc J, 14 (10), pp. E475-E481, 2020, ISSN: 1911-6470.

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Loubersac T, Nguile-Makao M, Pouliot F, Fradet V, Toren P

Neutrophil-to-lymphocyte Ratio as a Predictive Marker of Response to Abiraterone Acetate: A Retrospective Analysis of the COU302 Study.

Journal Article

Eur Urol Oncol, 3 (3), pp. 298-305, 2020, ISSN: 2588-9311.

Abstract | Links:

Leong DP, Fradet V, Shayegan B, Duceppe E, Siemens R, Niazi T, Klotz L, Brown I, Chin J, Lavallee L, Mousavi N, Luke P, Lukka H, Gopaul D, Violette P, Hamilton RJ, Davis MK, Karampatos S, Mian R, Delouya G, Fradet Y, Mukherjee S, Conen D, Chen-Tournoux A, Johnson C, Bessissow A, Dresser G, Hameed AK, Abdel-Qadir H, Sener A, Pal R, Devereaux PJ, Pinthus J, RADICAL PC Investigators

Cardiovascular Risk in Men with Prostate Cancer: Insights from the RADICAL PC Study.

Journal Article

J Urol, 203 (6), pp. 1109-1116, 2020, ISSN: 0022-5347.

Abstract | Links:

Moussa H, Nguile-Makao M, Robitaille K, Guertin MH, Allaire J, Pelletier JF, Moreel X, Gevariya N, Diorio C, Desmeules P, Tetu B, Lamarche B, Julien P, Fradet V

Omega-3 Fatty Acids Survey in Men under Active Surveillance for Prostate Cancer: from Intake to Prostate Tissue Level.

Journal Article

Nutrients, 11 (7), 2019, ISSN: 2072-6643.

Abstract | Links:

Lavallee E, Bergeron M, Buteau FA, Blouin AC, Duchesnay N, Dujardin T, Tiguert R, Lacombe L, Fradet V, Makao-Nguile M, Fradet Y, Beauregard JM, Pouliot F

Increased Prostate Cancer Glucose Metabolism Detected by 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Localised Gleason 8-10 Prostate Cancers Identifies Very High-risk Patients for Early Recurrence and Resistance to Castration.

Journal Article

Eur Urol Focus, 5 (6), pp. 998-1006, 2019.

Abstract | Links:

Gevariya N, Besancon M, Robitaille K, Picard V, Diabate L, Alesawi A, Julien P, Fradet Y, Bergeron A, Fradet V

Omega-3 fatty acids decrease prostate cancer progression associated with an anti-tumor immune response in eugonadal and castrated mice.

Journal Article

Prostate, 79 (1), pp. 9-20, 2019, ISSN: 0270-4137.

Abstract | Links:

39 entries « 1 of 4 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
  • En route towards prebiotic clinical trials for enhancement of immunotherapies in bladder and prostate cancers, Subvention, The W. Garfield Weston Foundation, Transformational Research, from 2020-06-01 to 2023-05-31
  • Institut sur la nutrition et les aliments fonctionnels (INAF), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2017-04-01 to 2024-03-31
  • Interaction between environment, diet, physical activities, and sexual habits, in the risk of prostate cancer. Validation of biomarkers to personnalize preventive interventions., Subvention, Société de recherche sur le cancer, Compétition GRePEC (SRC/FRSQ/MDEIE), from 2012-10-01 to 2021-12-31
  • Nutrition, santé et société (NUTRISS), Subvention, Fonds de recherche du Québec - Santé, Nouveaux Centres et Instituts de recherche - Subventions régulières, from 2019-04-01 to 2024-03-31
  • Territorialiser les systèmes alimentaires : une révolution pour la planète et la santé durable, Subvention, Alliance santé Québec (AsQ), from 2020-04-01 to 2021-03-31

Recently finished projects

  • (FRSQ 85605) Plateforme méthodologique du CRCEO (statistiques uro-oncologie) , Subvention, Fondation du CHU de Québec, from 2019-05-30 to 2020-05-29
  • Détresse et satisfactions face au processus informationnel et décisionnel lors d'un cancer de la prostate localisé, Subvention, Fondation de l'Université Laval, from 2017-02-01 to 2020-03-31
  • Impact of microbiota on prostate cancer: from gut to tumor microenvironment., Subvention, Centre hospitalier universitaire de Montréal, from 2018-12-01 to 2019-12-31
  • Plateforme méthodologique du Centre de Recherche Clinique et Evaluative en Oncoloie (CRCEO) uro-oncologie, Subvention, Fondation du CHU de Québec, from 2019-03-05 to 2020-03-04
  • Prebiotics to enhance immunotherapy response in bladder cancer, Subvention, The W. Garfield Weston Foundation, 2018 Proof-of-Principle Grant Call, from 2019-01-01 to 2020-12-31
  • Projet de recherche CaptoMD : Cancer de la prostate, Subvention, Fondation du CHU de Québec, from 2019-03-22 to 2020-03-21
  • Rôle du microbiote intestinal dans le cancer de la prostate, Subvention, Université Laval - Soutien à la recherche, from 2018-05-01 to 2019-04-30
  • Toward nutritional and epigenomic interventions in prostate cancer prevention and management, Subvention, Instituts de recherche en santé du Canada, Fonctionnement: Subvention de promotion de l’impact - CCREES, from 2017-10-01 to 2020-09-30
Data provided by the Université Laval research projects registery