Following her training in Paris, France, Dr. Moulin was recruited in 1998 to better understand the complex process of healing. Since 1998, she has been a professor at the Laval University School of Medicine, Department of Surgery, but also a researcher at the LOEX Center at Laval University, and at the Research Center of the CHU de Quebec. Her work focuses on the normal and pathological mechanisms of skin healing. To perform this, she uses different cell culture models reconstituted by tissue engineering to reproduce in vitro fibrotic skin diseases (hypertrophic scars, scleroderma). Concurrently, she also uses the tissue engineering method to reconstruct cutaneous substitutes to treat skin deficient patients, for example, after burns.

Myofibroblasts in normal or pathological scars
These cells appear during wound healing and play an important role in the contraction of the edges of the wound. Dr. Moulin’s team has shown that these cells also play a central role in the production of extracellular matrix, as well as in angiogenesis. They also have a role in the formation of disabling scars such as hypertrophic scars. Dr. Moulin’s team analyzes the different functions of myofibroblasts in normal or pathological scarring; investigates existing interactions between endothelial cells, keratinocytes, fibroblasts and myofibroblasts, and analyzes the role of extracellular matrix secreted by cells in various cellular functions such as apoptosis, angiogenesis or cell differentiation.

Systemic scleroderma
This pathology is a fibrotic disease that stiffens all organs, including the skin, and is eventually fatal. Dr. Moulin uses a tissue-engineering method to understand this pathology, but especially to determine new treatments to reduce fibrosis.

Clinical application of tissue engineering
Tissue engineering skin production is carried out from patients’ cells and then grafted onto them to allow wound closure in patients who are unable to heal after extensive burns or other pathologies. The properties of skin reconstructed by our method are being evaluated in a clinical trial accepted by Health Canada to cover burn victims.

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Arif S, Larochelle S, Moulin VJ

PLGF-1 contained in normal wound myofibroblast-derived microvesicles stimulated collagen production by dermal fibroblasts.

Journal Article

J Cell Commun Signal, 2020, ISSN: 1873-9601.

Abstract | Links:

Molina Martins R, Alves G, Martins S, de Freitas LA, Rochette P, Moulin V, Fonseca M

Apple Extract (Malus sp.) and Rutin as Photochemopreventive Agents: Evaluation of Ultraviolet B-Induced Alterations on Skin Biopsies and Tissue-Engineered Skin.

Journal Article

Rejuvenation Res, 2020, ISSN: 1549-1684.

Abstract | Links:

Roy V, Magne B, Vaillancourt-Audet M, Blais M, Chabaud S, Grammond E, Piquet L, Fradette J, Laverdiere I, Moulin VJ, Landreville S, Germain L, Auger FA, Gros-Louis F, Bolduc S

Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors.

Journal Article

Biomed Res Int, 2020 , pp. 6051210, 2020.

Abstract | Links:

Laberge A, Ayoub A, Arif S, Larochelle S, Garnier A, Moulin VJ

α-2-Macroglobulin induces the shedding of microvesicles from cutaneous wound myofibroblasts.

Journal Article

J Cell Physiol, 234 (7), pp. 11369-11379, 2019, ISSN: 0021-9541.

Abstract | Links:

Bourland J, Mayrand D, Tremblay N, Moulin VJ, Fradette J, Auger FA

Isolation and Culture of Human Dermal Microvascular Endothelial Cells.

Journal Article

Methods Mol Biol, 1993 , pp. 79-90, 2019, ISSN: 1064-3745.

Abstract | Links:

Germain L, Larouche D, Nedelec B, Perreault I, Duranceau L, Bortoluzzi P, Beaudoin Cloutier C, Genest H, Caouette-Laberge L, Dumas A, Bussiere A, Boghossian E, Kanevsky J, Leclerc Y, Lee J, Nguyen MT, Bernier V, Knoppers BM, Moulin VJ, Auger FA

Autologous bilayered self-assembled skin substitutes (SASSs) as permanent grafts: a case series of 14 severely burned patients indicating clinical effectiveness.

Journal Article

Eur Cell Mater, 36 , pp. 128-141, 2018.

Abstract | Links:

Dakiw Piaceski A, Larouche D, Ghani K, Bisson F, Cortez Ghio S, Larochelle S, Moulin MJ, Caruso M, Germain L

Translating the combination of gene therapy and tissue engineering for treating recessive dystrophic epidermolysis bullosa.

Journal Article

Eur Cell Mater, 35 , pp. 73-86, 2018.

Abstract | Links:

Laberge A, Arif S, Moulin VJ

Microvesicles: Intercellular messengers in cutaneous wound healing.

Journal Article

J Cell Physiol, 233 (8), pp. 5550-5563, 2018, ISSN: 0021-9541.

Abstract | Links:

Simard-Bisson C, Parent LA, Moulin VJ, Fruteau de Laclos B

Characterization of Epidermal Lipoxygenase Expression in Normal Human Skin and Tissue-Engineered Skin Substitutes.

Journal Article

J Histochem Cytochem, 66 (11), pp. 813-824, 2018, ISSN: 0022-1554.

Abstract | Links:

Laberge A, Moulin VJ

The role of microvesicles in cutaneous wound healing (Chapter 4)

Book Chapter

K, Turksen (Ed.): Wound Healing: Stem Cells Repair and Restorations, Basic and Clinical Aspects, pp. 43-66, Hoboken, NJ, John Wiley & Sons, Inc, 2018, ISBN: 978-1-119-28248-8.

| Links:

55 entries « 1 of 6 »
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Active projects

  • Action des microvésicules dans les tissus solides, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2019-04-01 to 2024-03-31
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en organogenèse expérimentale, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2011-05-01 to 2020-09-22
  • Mise au point par génie tissulaire d'un modèle de cicatrisation cutanée contenant des cellules immunitaires, Partenariat, MITACS Inc., Accélération Québec (MITACS et gouvernement provincial), from 2019-01-27 to 2021-09-30
  • Self-Assembly Skin Substitutes (SASS) for the treatment of acute wounds of Canadian burn patients, Subvention, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Réseau de centres d'excellence (RCE), from 2020-01-01 to 2022-01-31
  • The Canadian National Transplant Research Program : Increasing Donation and Improving Transplantation Outcomes, Subvention, Instituts de recherche en santé du Canada, Autre : Recherche sur la transplantation, from 2013-04-01 to 2022-03-31

Recently finished projects

  • Bourses-Desjardins et Axe Médecine régénératrice, Subvention, Fondation du CHU de Québec, from 2019-01-17 to 2020-01-16
  • Centre de recherche en arthrite de l'Université Laval, Subvention, Institutionnel - BDR, BDR - Entités de recherche en émergence, from 2019-01-01 to 2020-01-31
  • Développement de procédures d’opération standard pour l’expédition de matériel biologique à température de la pièce, Subvention, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Réseau de centres d'excellence (RCE), from 2017-09-15 to 2020-03-31
  • Extracellular vesicles secreted by uveal melanoma cells: role and clinical value, Subvention, Fonds de recherche du Québec - Santé, Programme Réseautage national et international, from 2018-04-01 to 2020-03-31
Data provided by the Université Laval research projects registery