Dr. Bourgoin is a regular researcher at the Research Center of Quebec – Laval University and Professor in the Department of Microbiology-Infectiology and Immunology of the Faculty of Medicine at Laval University. His work focuses on lipid mediators of inflammation in systemic autoimmune diseases and dysfunction of innate immunity cells.

Dr. Bourgoin has published more than 100 articles in scientific journals (Google Scholar h-index of 39). His work has been the subject of several editorial reviews of scientific journals in 2108 (Molecular Pharmacology) and in 2011 (Journal of Leukocyte Biology). Dr. Bourgoin contributes to the influence of the CHU Research Centre and Laval University by organizing international symposia on neutrophils in immunity (2012, 2014, 2016, 2018).

Understanding early atherosclerosis in rheumatic autoimmune diseases:

Accelerated atherosclerosis, associated with systemic autoimmune diseases, such as lupus erythematosus and rheumatoid arthritis, significantly increases the risk of cardiovascular events. The lipid mediators of inflammation play an amplifying role in the development of atherosclerosis, promoting the recruitment of immune system cells and the thickening of the vessel wall. Strategies to reduce cardiovascular risks associated with lupus erythematosus and rheumatoid arthritis remain to be clarified.

A new target to treat leukemia:

Myeloid leukemias are blood cancers whose origin is an anarchic production of white blood cells, from the bone marrow. These cells are usually immature, and unable to fight infections. Their presence also tends to disrupt the production of red blood cells, and cause a decline in the production of platelets. Genetic and epigenetic modifications alter the expression or function of proteins that act as positive or negative regulators of proliferation. These molecular switches abundant in leukemic myeloid cells act as positive regulators of proliferation, while inhibiting their differentiation into functional white blood cells.

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98 entries « 9 of 10 »

Richard A, Robichaud G, Lapointe R, Bourgoin S, Darveau A, Poulin L

Interference of HIV-1 Nef in the sphingomyelin transduction pathway activated by tumour necrosis factor-alpha in human glial cells.

Journal Article

AIDS, 11 (1), pp. F1-7, 1997, ISSN: 0269-9370.

Abstract | Links:

Bourgoin SG, Harbour D, Poubelle PE

Role of protein kinase C alpha, Arf, and cytoplasmic calcium transients in phospholipase D activation by sodium fluoride in osteoblast-like cells.

Journal Article

J Bone Miner Res, 11 (11), pp. 1655-65, 1996, ISSN: 0884-0431.

Abstract | Links:

Marshansky V, Fleser A, Noël J, Bourgoin S, Vinay P

Isolation of heavy endosomes from dog proximal tubules in suspension.

Journal Article

J Membr Biol, 153 (1), pp. 59-73, 1996, ISSN: 0022-2631.

Abstract | Links:

Richard A, Bourgoin S, Naccache PH, L'Heureux GP, Krump E, McColl SR, Pelletier G

C2-ceramide primes specifically for the superoxide anion production induced by N-formylmethionylleucyl phenylalanine (fMLP) in human neutrophils.

Journal Article

Biochim Biophys Acta, 1299 (2), pp. 259-66, 1996, ISSN: 0006-3002.

Abstract | Links:

Houle MG, Bourgoin S

Small GTPase-regulated phospholipase D in granulocytes.

Journal Article

Biochem Cell Biol, 74 (4), pp. 459-67, 1996, ISSN: 0829-8211.

Abstract | Links:

Houle MG, Kahn RA, Naccache PH, Bourgoin S

ADP-ribosylation factor translocation correlates with potentiation of GTP gamma S-stimulated phospholipase D activity in membrane fractions of HL-60 cells.

Journal Article

J Biol Chem, 270 (39), pp. 22795-800, 1995, ISSN: 0021-9258.

Abstract | Links:

L'Heureux GP, Bourgoin S, Jean N, McColl SR, Naccache PH

Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: interleukin-8, but not NAP-2 or GRO alpha, stimulates phospholipase D activity.

Journal Article

Blood, 85 (2), pp. 522-31, 1995, ISSN: 0006-4971.

Abstract | Links:

Bourgoin SG

Régulation de la phospholipase D par les protéines G de faible poids moléculaire : réalités et perspectives

Journal Article

Med Sci (Paris), 11 (3), pp. 476-477, 1995, ISSN: 0767-0974.

Naccache PH, Caon AC, Gilbert C, Gaudry M, Roberge CJ, Poubelle PE, Bourgoin S

Inhibition of tyrosine phosphorylation by wortmannin in human neutrophils. Dissociation from its inhibitory effects on phospholipase D.

Journal Article

Lab Invest, 69 (1), pp. 19-23, 1993, ISSN: 0023-6837.

Abstract | Links:

Naccache PH, Bourgoin S, Plante E, Roberge CJ, de Medicis R, Lussier A, Poubelle PE

Crystal-induced neutrophil activation. II. Evidence for the activation of a phosphatidylcholine-specific phospholipase D.

Journal Article

Arthritis Rheum, 36 (1), pp. 117-25, 1993, ISSN: 0004-3591.

Abstract | Links:

98 entries « 9 of 10 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Role of autotaxin bound to platelet-derived microparticles to development of vascular damage in arthritis., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2021-06-30

Recently finished projects

  • Centre de recherche en arthrite de l'Université Laval, Subvention, Institutionnel - BDR, BDR - Entités de recherche en émergence, from 2019-01-01 to 2020-01-31
Data provided by the Université Laval research projects registery