Dr. Bourgoin is a regular researcher at the Research Center of Quebec – Laval University and Professor in the Department of Microbiology-Infectiology and Immunology of the Faculty of Medicine at Laval University. His work focuses on lipid mediators of inflammation in systemic autoimmune diseases and dysfunction of innate immunity cells.

Dr. Bourgoin has published more than 100 articles in scientific journals (Google Scholar h-index of 39). His work has been the subject of several editorial reviews of scientific journals in 2108 (Molecular Pharmacology) and in 2011 (Journal of Leukocyte Biology). Dr. Bourgoin contributes to the influence of the CHU Research Centre and Laval University by organizing international symposia on neutrophils in immunity (2012, 2014, 2016, 2018).

Understanding early atherosclerosis in rheumatic autoimmune diseases:

Accelerated atherosclerosis, associated with systemic autoimmune diseases, such as lupus erythematosus and rheumatoid arthritis, significantly increases the risk of cardiovascular events. The lipid mediators of inflammation play an amplifying role in the development of atherosclerosis, promoting the recruitment of immune system cells and the thickening of the vessel wall. Strategies to reduce cardiovascular risks associated with lupus erythematosus and rheumatoid arthritis remain to be clarified.

A new target to treat leukemia:

Myeloid leukemias are blood cancers whose origin is an anarchic production of white blood cells, from the bone marrow. These cells are usually immature, and unable to fight infections. Their presence also tends to disrupt the production of red blood cells, and cause a decline in the production of platelets. Genetic and epigenetic modifications alter the expression or function of proteins that act as positive or negative regulators of proliferation. These molecular switches abundant in leukemic myeloid cells act as positive regulators of proliferation, while inhibiting their differentiation into functional white blood cells.

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Zhao C, Hui W, Fernandes MJ, Poubelle PE, Bourgoin SG

Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes.

Journal Article

Biochem Pharmacol, 90 (1), pp. 62-72, 2014, ISSN: 0006-2952.

Abstract | Links:

Bourgoin SG, Zhao C, Fernandes MJ

Targeting the metabolism and receptors of sphingosine-1- phosphate for the treatment of rheumatoid arthritis

Book Chapter

A, Lemmey (Ed.): Rheumatoid Arthritis - Treatment, pp. 195-210, Rijeka, InTech, 2012, ISBN: 978-953-307-850-2 .

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Bourgoin SG, El Azreq MA

Small inhibitors of ADP-ribosylation factor activation and function in mammalian cells

Journal Article

World Journal of Pharmacology, 1 (4), pp. 55-64, 2012.

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El Azreq MA, Bourgoin SG

Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through β2 integrin activation.

Journal Article

Mol Immunol, 48 (12-13), pp. 1408-16, 2011, ISSN: 0161-5890.

Abstract | Links:

Zhao C, Sardella A, Chun J, Poubelle PE, Fernandes MJ, Bourgoin SG

TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines.

Journal Article

J Lipid Res, 52 (7), pp. 1307-18, 2011, ISSN: 0022-2275.

Abstract | Links:

El Azreq MA, Garceau V, Bourgoin SG

Cytohesin-1 regulates fMLF-mediated activation and functions of the β2 integrin Mac-1 in human neutrophils.

Journal Article

J Leukoc Biol, 89 (6), pp. 823-36, 2011, ISSN: 0741-5400.

Abstract | Links:

Faugaret D, Chouinard FC, Harbour D, El Azreq MA, Bourgoin SG

An essential role for phospholipase D in the recruitment of vesicle amine transport protein-1 to membranes in human neutrophils.

Journal Article

Biochem Pharmacol, 81 (1), pp. 144-56, 2011, ISSN: 0006-2952.

Abstract | Links:

Bourgoin SG, Zhao C

Autotaxin and lysophospholipids in rheumatoid arthritis.

Journal Article

Curr Opin Investig Drugs, 11 (5), pp. 515-26, 2010, ISSN: 1472-4472.

Abstract | Links:

El Azreq MA, Garceau V, Harbour D, Pivot-Pajot C, Bourgoin SG

Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion.

Journal Article

J Immunol, 184 (2), pp. 637-49, 2010, ISSN: 0022-1767.

Abstract | Links:

Pivot-Pajot C, Chouinard FC, El Azreq MA, Harbour D, Bourgoin SG

Characterisation of degranulation and phagocytic capacity of a human neutrophilic cellular model, PLB-985 cells.

Journal Article

Immunobiology, 215 (1), pp. 38-52, 2010, ISSN: 0171-2985.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Role of autotaxin bound to platelet-derived microparticles to development of vascular damage in arthritis., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2021-06-30

Recently finished projects

  • Centre de recherche en arthrite de l'Université Laval, Subvention, Institutionnel - BDR, BDR - Entités de recherche en émergence, from 2019-01-01 to 2020-01-31
Data provided by the Université Laval research projects registery