Dr. Bourgoin is a regular researcher at the Research Center of Quebec – Laval University and Professor in the Department of Microbiology-Infectiology and Immunology of the Faculty of Medicine at Laval University. His work focuses on lipid mediators of inflammation in systemic autoimmune diseases and dysfunction of innate immunity cells.

Dr. Bourgoin has published more than 100 articles in scientific journals (Google Scholar h-index of 39). His work has been the subject of several editorial reviews of scientific journals in 2108 (Molecular Pharmacology) and in 2011 (Journal of Leukocyte Biology). Dr. Bourgoin contributes to the influence of the CHU Research Centre and Laval University by organizing international symposia on neutrophils in immunity (2012, 2014, 2016, 2018).

Understanding early atherosclerosis in rheumatic autoimmune diseases:

Accelerated atherosclerosis, associated with systemic autoimmune diseases, such as lupus erythematosus and rheumatoid arthritis, significantly increases the risk of cardiovascular events. The lipid mediators of inflammation play an amplifying role in the development of atherosclerosis, promoting the recruitment of immune system cells and the thickening of the vessel wall. Strategies to reduce cardiovascular risks associated with lupus erythematosus and rheumatoid arthritis remain to be clarified.

A new target to treat leukemia:

Myeloid leukemias are blood cancers whose origin is an anarchic production of white blood cells, from the bone marrow. These cells are usually immature, and unable to fight infections. Their presence also tends to disrupt the production of red blood cells, and cause a decline in the production of platelets. Genetic and epigenetic modifications alter the expression or function of proteins that act as positive or negative regulators of proliferation. These molecular switches abundant in leukemic myeloid cells act as positive regulators of proliferation, while inhibiting their differentiation into functional white blood cells.

CHUL
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T1-58
Québec, Québec
Canada G1V 4G2
103 entries « 1 of 11 »

Hasse S, Duchez AC, Fortin P, Boilard E, Bourgoin SG

Interplay between LPA2 and LPA3 in LPA-mediated phosphatidylserine cell surface exposure and extracellular vesicles release by erythrocytes.

Journal Article

Biochem Pharmacol, 192 , 2021.

Abstract | Links:

Gamara J, Davis L, Leong AZ, Pagé N, Rollet-Labelle E, Zhao C, Hongu T, Funakoshi Y, Kanaho Y, Aoudji F, Pelletier M, Bourgoin SG

Arf6 regulates energy metabolism in neutrophils.

Journal Article

Free Radic Biol Med, 172 , 2021.

Abstract | Links:

Marcoux G, Laroche A, Hasse S, Bellio M, Mbarik M, Tamagne M, Allaeys I, Zufferey A, Lévesque T, Rebetz J, Karakeussian-Rimbaud A, Turgeon J, Bourgoin SG, Hamzeh-Cognasse H, Cognasse F, Kapur R, Semple JW, Hebert MJ, Pirenne F, Overkleeft H, Florea B, Dieude M, Vingert B, Boilard E

Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules.

Journal Article

Blood, 2021.

Abstract | Links:

Zhao Y, Hasse S, Bourgoin SG

Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise.

Journal Article

Prog Lipid Res, 83 , 2021.

Abstract | Links:

Allaeys I, Ribeiro de Vargas F, Bourgoin SG, Poubelle PE

Human Inflammatory Neutrophils Express Genes Encoding Peptidase Inhibitors: Production of Elafin Mediated by NF-κB and CCAAT/Enhancer-Binding Protein β.

Journal Article

J Immunol, 206 (8), 2021.

Abstract | Links:

Gamara J, Davis L, Rollet-Labelle E, Hongu T, Funakoshi Y, Kanaho Y, Aoudjit F, Bourgoin SG

Assessment of Arf6 Deletion in PLB-985 Differentiated in Neutrophil-Like Cells and in Mouse Neutrophils: Impact on Adhesion and Migration.

Journal Article

Mediators Inflamm, 2020 , 2020.

Abstract | Links:

Zhao Y, Hasse S, Zhao C, Bourgoin SG

Targeting the autotaxin - Lysophosphatidic acid receptor axis in cardiovascular diseases.

Journal Article

Biochem Pharmacol, 164 , 2019.

Abstract | Links:

Zhao C, Amiable N, Laflamme M, Marsolais D, Di Battista JA, Fernandes MJ, Bourgoin SG

Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion?

Journal Article

Biochem Pharmacol, 165 , 2019.

Abstract | Links:

Hui W, Zhao C, Bourgoin SG

Differential Effects of Inhibitor Combinations on Lysophosphatidic Acid-Mediated Chemokine Secretion in Unprimed and Tumor Necrosis Factor-α-Primed Synovial Fibroblasts.

Journal Article

Front Pharmacol, 8 , 2017.

Abstract | Links:

Gendron DR, Lecours PB, Lemay AM, Beaulieu MJ, Huppe CA, Lee-Gosselin A, Flamand N, Don AS, Bissonnette E, Blanchet MR, Laplante M, Bourgoin SG, Bosse Y, Marsolais D

A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma.

Journal Article

Front Pharmacol, 8 , 2017.

Abstract | Links:

103 entries « 1 of 11 »
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Active projects

  • Centre de recherche en arthrite (ARThrite), from 2020-11-03 to 2026-04-30

Recently finished projects

  • Centre de recherche en arthrite de l'Université Laval, from 2019-01-01 to 2020-01-31
  • Role of autotaxin bound to platelet-derived microparticles to development of vascular damage in arthritis., from 2015-07-01 to 2021-06-30
Data provided by the Université Laval research projects registery