Dr. Bourgoin is a regular researcher at the Research Center of Quebec – Laval University and Professor in the Department of Microbiology-Infectiology and Immunology of the Faculty of Medicine at Laval University. His work focuses on lipid mediators of inflammation in systemic autoimmune diseases and dysfunction of innate immunity cells.

Dr. Bourgoin has published more than 100 articles in scientific journals (Google Scholar h-index of 39). His work has been the subject of several editorial reviews of scientific journals in 2108 (Molecular Pharmacology) and in 2011 (Journal of Leukocyte Biology). Dr. Bourgoin contributes to the influence of the CHU Research Centre and Laval University by organizing international symposia on neutrophils in immunity (2012, 2014, 2016, 2018).

Understanding early atherosclerosis in rheumatic autoimmune diseases:

Accelerated atherosclerosis, associated with systemic autoimmune diseases, such as lupus erythematosus and rheumatoid arthritis, significantly increases the risk of cardiovascular events. The lipid mediators of inflammation play an amplifying role in the development of atherosclerosis, promoting the recruitment of immune system cells and the thickening of the vessel wall. Strategies to reduce cardiovascular risks associated with lupus erythematosus and rheumatoid arthritis remain to be clarified.

A new target to treat leukemia:

Myeloid leukemias are blood cancers whose origin is an anarchic production of white blood cells, from the bone marrow. These cells are usually immature, and unable to fight infections. Their presence also tends to disrupt the production of red blood cells, and cause a decline in the production of platelets. Genetic and epigenetic modifications alter the expression or function of proteins that act as positive or negative regulators of proliferation. These molecular switches abundant in leukemic myeloid cells act as positive regulators of proliferation, while inhibiting their differentiation into functional white blood cells.

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Zhao C, Amiable N, Laflamme M, Marsolais D, Di Battista JA, Fernandes MJ, Bourgoin SG

Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion?

Journal Article

Biochem Pharmacol, 2019, ISSN: 0006-2952.

Abstract | Links:

Gendron DR, Lecours PB, Lemay AM, Beaulieu MJ, Huppe CA, Lee-Gosselin A, Flamand N, Don AS, Bissonnette E, Blanchet MR, Laplante M, Bourgoin SG, Bosse Y, Marsolais D

A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma.

Journal Article

Front Pharmacol, 8 , pp. 78, 2017.

Abstract | Links:

Hui W, Zhao C, Bourgoin SG

Differential Effects of Inhibitor Combinations on Lysophosphatidic Acid-Mediated Chemokine Secretion in Unprimed and Tumor Necrosis Factor-α-Primed Synovial Fibroblasts.

Journal Article

Front Pharmacol, 8 , pp. 848, 2017.

Abstract | Links:

Zhao C, Sardella A, Davis L, Poubelle PE, Bourgoin SG, Fernandes MJ

A transgenic mouse model for the in vivo bioluminescence imaging of the expression of the lysophosphatidic acid receptor 3: relevance for inflammation and uterine physiology research.

Journal Article

Transgenic Res, 24 (4), pp. 625-34, 2015, ISSN: 0962-8819.

Abstract | Links:

Gamara J, Chouinard F, Davis L, Aoudjit F, Bourgoin SG

Regulators and Effectors of Arf GTPases in Neutrophils.

Journal Article

J Immunol Res, 2015 , pp. 235170, 2015, ISSN: 2314-7156.

Abstract | Links:

Hui W, Zhao C, Bourgoin SG

LPA Promotes T Cell Recruitment through Synthesis of CXCL13.

Journal Article

Mediators Inflamm, 2015 , pp. 248492, 2015, ISSN: 0962-9351.

Abstract | Links:

Zhao C, Moreno-Nieves U, Di Battista JA, Fernandes MJ, Touaibia M, Bourgoin SG

Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts.

Journal Article

Mediators Inflamm, 2015 , pp. 436525, 2015, ISSN: 0962-9351.

Abstract | Links:

Bourgoin SG, Hui W

Role of mitogen- and stress-activated kinases in inflammatory arthritis

Journal Article

World Journal of Pharmacology, 4 (4), pp. 265-273, 2015.

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Zhao C, Hui W, Fernandes MJ, Poubelle PE, Bourgoin SG

Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes.

Journal Article

Biochem Pharmacol, 90 (1), pp. 62-72, 2014, ISSN: 0006-2952.

Abstract | Links:

Bourgoin SG, Zhao C, Fernandes MJ

Targeting the metabolism and receptors of sphingosine-1- phosphate for the treatment of rheumatoid arthritis

Book Chapter

A, Lemmey (Ed.): Rheumatoid Arthritis - Treatment, pp. 195-210, Rijeka, InTech, 2012, ISBN: 978-953-307-850-2 .

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Active projects

  • Centre de recherche en arthrite de l'Université Laval, Subvention, Institutionnel - BDR, BDR - Entités de recherche en émergence, from 2019-01-01 to 2020-01-31
  • Centre hospitalier universitaire de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Role of autotaxin bound to platelet-derived microparticles to development of vascular damage in arthritis., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2020-06-30

Recently finished projects

  • Neutrophil 2018, Subvention, Instituts de recherche en santé du Canada, Subvention de planification et dissémination, from 2017-11-01 to 2018-03-31
Data provided by the Université Laval research projects registery