Dr. Steve Bilodeau is an associate professor at Laval University (Department of Molecular Biology, Medical Biochemistry and Pathology, School of Medicine) and has been a principal investigator for the oncology axis of the Centre de recherche du CHU de Québec-Laval University, since 2012. In addition to being finalist for the Maud-Menten New Principal Investigator prize, Dr. Bilodeau holds the Canada Research Chair in transcriptional genomics.

Research interests

Since his training at the prestigious Massachusetts Institute of Technology (MIT, 2007-2012), Dr. Bilodeau has studied the molecular mechanisms controlling gene expression during normal and disease development. Indeed, despite common genetic material, each cell has a unique gene expression program that is specific to its function. An imbalance in this program changes the daily operations of the cell; instructing a new role in the process. Therapeutic approaches currently focus on the destruction of defective cells or on treating symptoms associated with the disease. The premise of Dr. Bilodeau’s lab is that, if the gene expression program can be controlled, all cells, healthy or diseased, can be controlled as well.

Research program

Dr. Bilodeau’s research is funded by the Canadian Institutes of Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada (NSERC). His work aims to integrate the multiple layers of information from the nuclear environment (chromosome structure, chromatin, regulators, etc.) in order to determine which genes are prioritized by a given cell during a transcriptional response triggered by an environmental change. More specifically, Dr. Bilodeau’s team seeks to understand the biological role of the three-dimensional organization of the genome in the communication between genes. The findings of Dr. Bilodeau’s team provide the basic information needed to understand the role of noncoding regulatory regions, which frequently harbor genetic events associated with multiple diseases, in maintaining the transcriptional program. This problem affects both developmental syndromes and cancers.

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Whyte WA, Bilodeau S, Orlando DA, Hoke HA, Frampton GM, Foster CT, Cowley SM, Young RA

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation.

Journal Article

Nature, 482 (7384), pp. 221-5, 2012, ISSN: 0028-0836.

Abstract | Links:

Mullen AC, Orlando DA, Newman JJ, Loven J, Kumar RM, Bilodeau S, Reddy J, Guenther MG, DeKoter RP, Young RA

Master transcription factors determine cell-type-specific responses to TGF-β signaling.

Journal Article

Cell, 147 (3), pp. 565-76, 2011, ISSN: 0092-8674.

Abstract | Links:

Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferre F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, Beroukhim R, Mermel CH, Loda M, Ait-Si-Ali S, Garraway LA, Young RA, Zon LI

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset.

Journal Article

Nature, 471 (7339), pp. 513-7, 2011, ISSN: 0028-0836.

Abstract | Links:

Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA

Mediator and cohesin connect gene expression and chromatin architecture.

Journal Article

Nature, 467 (7314), pp. 430-5, 2010, ISSN: 0028-0836.

Abstract | Links:

Roussel-Gervais A, Bilodeau S, Vallette S, Berthelet F, Lacroix A, Figarella-Branger D, Brue T, Drouin J

Cooperation between cyclin E and p27(Kip1) in pituitary tumorigenesis.

Journal Article

Mol Endocrinol, 24 (9), pp. 1835-45, 2010, ISSN: 0888-8809.

Abstract | Links:

Drouin J, Bilodeau S, Roussel-Gervais A

Stem cells, differentiation and cell cycle control in pituitary.

Journal Article

Front Horm Res, 38 , pp. 15-24, 2010, ISSN: 0301-3073.

Abstract | Links:

Bilodeau S, Kagey MH, Frampton GM, Rahl PB, Young RA

SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state.

Journal Article

Genes Dev, 23 (21), pp. 2484-9, 2009, ISSN: 0890-9369.

Abstract | Links:

Bilodeau S, Roussel-Gervais A, Drouin J

Distinct developmental roles of cell cycle inhibitors p57Kip2 and p27Kip1 distinguish pituitary progenitor cell cycle exit from cell cycle reentry of differentiated cells.

Journal Article

Mol Cell Biol, 29 (7), pp. 1895-908, 2009, ISSN: 0270-7306.

Abstract | Links:

Marson A, Foreman R, Chevalier B, Bilodeau S, Kahn M, Young RA, Jaenisch R

Wnt signaling promotes reprogramming of somatic cells to pluripotency.

Journal Article

Cell Stem Cell, 3 (2), pp. 132-5, 2008, ISSN: 1934-5909.

| Links:

Bilodeau S, Vallette-Kasic S, Gauthier Y, Figarella-Branger D, Brue T, Berthelet F, Lacroix A, Batista D, Stratakis C, Hanson J, Meij B, Drouin J

Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease.

Journal Article

Genes Dev, 20 (20), pp. 2871-86, 2006, ISSN: 0890-9369.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en données massives, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2016-06-07 to 2021-06-06
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
  • Chaire de recherche du Canada en génomique transcriptionnelle, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Chaires de recherche du Canada - Fonctionnement, from 2017-09-01 to 2022-08-31
  • Elucidation of bromodomain functions within SWI/SNF complexes (Prix), Subvention, Instituts de recherche en santé du Canada, Subvention Projet - Annonce de priorités : Prix : Chercheur en début de carrière dans le domaine du cancer, from 2020-03-01 to 2021-02-28
  • Elucidation of bromodomain functions within SWI/SNF complexes, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2020-04-01 to 2025-03-31
  • Toward defining the transcriptional ecosystem, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2019-04-01 to 2024-03-31
  • Toward nutritional and epigenomic interventions in prostate cancer prevention and management, Subvention, Instituts de recherche en santé du Canada, Fonctionnement: Subvention de promotion de l’impact - CCREES, from 2017-10-01 to 2020-09-30

Recently finished projects

  • Efficient and reliable shearing of chromatin for highthroughput analysis, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions d'outils et d'instruments de recherche (OIR), from 2019-03-28 to 2020-03-31
Data provided by the Université Laval research projects registery