Dr. Steve Bilodeau is an associate professor at Laval University (Department of Molecular Biology, Medical Biochemistry and Pathology, School of Medicine) and has been a principal investigator for the oncology axis of the Centre de recherche du CHU de Québec-Laval University, since 2012. In addition to being finalist for the Maud-Menten New Principal Investigator prize, Dr. Bilodeau holds the Canada Research Chair in transcriptional genomics.
Since his training at the prestigious Massachusetts Institute of Technology (MIT, 2007-2012), Dr. Bilodeau has studied the molecular mechanisms controlling gene expression during normal and disease development. Indeed, despite common genetic material, each cell has a unique gene expression program that is specific to its function. An imbalance in this program changes the daily operations of the cell; instructing a new role in the process. Therapeutic approaches currently focus on the destruction of defective cells or on treating symptoms associated with the disease. The premise of Dr. Bilodeau’s lab is that, if the gene expression program can be controlled, all cells, healthy or diseased, can be controlled as well.
Dr. Bilodeau’s research is funded by the Canadian Institutes of Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada (NSERC). His work aims to integrate the multiple layers of information from the nuclear environment (chromosome structure, chromatin, regulators, etc.) in order to determine which genes are prioritized by a given cell during a transcriptional response triggered by an environmental change. More specifically, Dr. Bilodeau’s team seeks to understand the biological role of the three-dimensional organization of the genome in the communication between genes. The findings of Dr. Bilodeau’s team provide the basic information needed to understand the role of noncoding regulatory regions, which frequently harbor genetic events associated with multiple diseases, in maintaining the transcriptional program. This problem affects both developmental syndromes and cancers.
9, rue McMahon
Canada G1R 2J6
Defining the Transcriptional Ecosystem.Journal Article
Mol Cell, 72 (6), pp. 920-924, 2018, ISSN: 1097-2765.
Author Correction: Enhancer decommissioning by LSD1 during embryonic stem cell differentiation.Journal Article
Nature, 562 (7728), pp. E24, 2018, ISSN: 0028-0836.
Connected Gene Communities Underlie Transcriptional Changes in Cornelia de Lange Syndrome.Journal Article
Genetics, 207 (1), pp. 139-151, 2017, ISSN: 0016-6731.
FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells.Journal Article
Sci Rep, 6 , pp. 34962, 2016, ISSN: 2045-2322.
metagene Profiles Analyses Reveal Regulatory Element's Factor-Specific Recruitment Patterns.Journal Article
PLoS Comput Biol, 12 (8), pp. e1004751, 2016, ISSN: 1553-734X.
Mutant cohesin affects RNA polymerase II regulation in Cornelia de Lange syndrome.Journal Article
Sci Rep, 5 , pp. 16803, 2015, ISSN: 2045-2322.
ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.Journal Article
Cell Rep, 6 (2), pp. 313-24, 2014.
Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements.Journal Article
Stem Cell Reports, 1 (5), pp. 371-8, 2013, ISSN: 2213-6711.
A chromatin switch for chromosome condensation.Journal Article
Dev Cell, 23 (6), pp. 1127-8, 2012, ISSN: 1534-5807.
X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner.Journal Article
Proc Natl Acad Sci U S A, 109 (32), pp. 13004-9, 2012, ISSN: 0027-8424.
- Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2023-04-30
- Centre hospitalier universitaire de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Chaire de recherche du Canada en génomique transcriptionnelle, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Chaires de recherche du Canada - Fonctionnement, from 2017-09-01 to 2022-08-31
- Toward nutritional and epigenomic interventions in prostate cancer prevention and management, Subvention, Instituts de recherche en santé du Canada, Fonctionnement: Subvention de promotion de l’impact - CCREES, from 2017-10-01 to 2020-09-30
Recently finished projects
- Chaire de recherche du Canada en génomique transcriptionnelle, Subvention, Secrétariat des Chaires de recherche du Canada, Chaires de recherche du Canada - Fonctionnement, from 2012-09-01 to 2017-08-31
- Connecting the Cell-Type Specific Chromosome Architecture to Gene Regulation, Development and Diseases, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2013-01-01 to 2018-03-31
- Coordinated chromosome domains enforce the gene expression program of cancer cells., Subvention, L'Institut de recherche de la Société canadienne du cancer, Subventions pour l'innovation, from 2015-08-01 to 2018-07-31
- Development of new technologies to study the connection between chromosome architecture and regulation of the gene expression program., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2013-04-01 to 2019-03-31