Dr. Stéphanie Proulx obtained her Ph.D. from the Université du Québec à Trois-Rivières in the Biophysics and cell biology program. She then pursued a post-doctoral internship at Laval University, where she developed an expertise in tissue engineering. Dr. Proulx is currently a researcher in the axis of regenerative medicine of the CHU de Québec-UL Research Center (St-Sacrement Hospital), an assistant Professor at the Laval University School of Medicine in the department of ophthalmology, and a researcher in the Center for research in experimental organogenesis of Laval University/LOEX. Dr. Proulx is also part of the board of directors of the Vision Health Research FRQS Network and the Cell and tissue therapy FRQS Network.

Understanding eye diseases using tissue engineering

The eye is a complex organ, and all its structures are important to have good vision. Despite advances in medicine, the causes of many eye diseases remain unclear. Using cell culture and tissue engineering, Dr. Proulx’s team developed three-dimensional models that allow to study the interactions that cells have between themselves, and with their environment. Comparing the models engineered with healthy cells with the models engineered using pathological cells, it is possible to advance our knowledge on the pathogenesis of various eye diseases. These models are also used to test different agents and for the development of new treatment strategies.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
CUO-Recherche
H2-04
Québec, Québec
Canada G1S 4L8
32 entries « 3 of 4 »

Brunette I, Rosolen SG, Carrier M, Abderrahman M, Nada O, Germain L, Proulx S

Comparison of the pig and feline models for full thickness corneal transplantation.

Journal Article

Vet Ophthalmol, 14 (6), pp. 365-77, 2011, ISSN: 1463-5216.

Abstract | Links:

Landry H, Aminian A, Hoffart L, Nada O, Bensaoula T, Proulx S, Carrier P, Germain L, Brunette I

Corneal endothelial toxicity of air and SF6.

Journal Article

Invest Ophthalmol Vis Sci, 52 (5), pp. 2279-86, 2011, ISSN: 0146-0404.

Abstract | Links:

Proulx S, Fradette J, Gauvin R, Larouche D, Germain L

Stem cells of the skin and cornea: their clinical applications in regenerative medicine.

Journal Article

Curr Opin Organ Transplant, 16 (1), pp. 83-9, 2011, ISSN: 1087-2418.

Abstract | Links:

Paquet C, Larouche D, Bisson F, Proulx S, Simard-Bisson C, Gaudreault M, Robitaille H, Carrier P, Martel I, Duranceau L, Auger FA, Fradette J, Guerin SL, Germain L

Tissue engineering of skin and cornea: Development of new models for in vitro studies.

Journal Article

Ann N Y Acad Sci, 1197 , pp. 166-77, 2010, ISSN: 0077-8923.

Abstract | Links:

Proulx S, Uwamaliya J, Carrier P, Deschambeault A, Audet C, Giasson CJ, Guerin SL, Auger FA, Germain L

Reconstruction of a human cornea by the self-assembly approach of tissue engineering using the three native cell types.

Journal Article

Mol Vis, 16 , pp. 2192-201, 2010.

Abstract | Links:

Proulx S, Guillemette M, Carrier P, Auger FA, Germain L, Giasson CJ, Gaudreault M, Guérin SL

Tissue engineering of the human cornea

Book Chapter

T, Chirila; D, Harkin (Ed.): Biomaterials and regenerative medicine in ophthalmology, pp. 150-192, Cambridge (UK), Woodhead Publishing (an imprint of Elsevier), 2010, ISBN: 184569743X, 9781845697433.

Proulx S, Audet C, Uwamaliya Jd, Deschambeault A, Carrier P, Giasson CJ, Brunette I, Germain L

Tissue engineering of feline corneal endothelium using a devitalized human cornea as carrier.

Journal Article

Tissue Eng Part A, 15 (7), pp. 1709-18, 2009, ISSN: 1937-3341.

Abstract | Links:

Proulx S, Bensaoula T, Nada O, Audet C, d'Arc Uwamaliya J, Devaux A, Allaire G, Germain L, Brunette I

Transplantation of a tissue-engineered corneal endothelium reconstructed on a devitalized carrier in the feline model.

Journal Article

Invest Ophthalmol Vis Sci, 50 (6), pp. 2686-94, 2009, ISSN: 0146-0404.

Abstract | Links:

Larouche D, Lavoie A, Proulx S, Paquet C, Carrier P, Beauparlant A, Auger FA, Germain L

[Regenerative medicine: stem cells, cellular and matricial interactions in the reconstruction of skin and cornea by tissue engineering].

Journal Article

Pathol Biol (Paris), 57 (4), pp. 299-308, 2009, ISSN: 0369-8114.

Abstract | Links:

Proulx S, Bourget JM, Gagnon N, Martel S, Deschambeault A, Carrier P, Giasson CJ, Auger FA, Brunette I, Germain L

Optimization of culture conditions for porcine corneal endothelial cells.

Journal Article

Mol Vis, 13 , pp. 524-33, 2007.

Abstract | Links:

32 entries « 3 of 4 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en organogenèse expérimentale, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2011-05-01 to 2020-09-22
  • Fuchs endothelial corneal dystrophy and corneal transplantation: The traditional paradigm revisited, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-10-01 to 2024-09-30
  • Improving Corneal Endothelial Cell Adhesion, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2023-03-31
  • Improving Corneal Endothelial Cell Adhesion, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-07-01 to 2022-06-30
  • Influence du TFG-ß et de l’environnent physique sur la formation des jonctions intercellulaires et la transition endothélio-mésenchymateuse, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2018-04-01 to 2023-03-31
  • New Functional Polymers for Next Generation Contact Lenses - a Phase I Project, Subvention, Conseil de recherches en sciences naturelles et génie Canada, De l'idée à l'innovation (INNOV), from 2019-07-01 to 2021-06-30
  • Reformation d’un endothélium cornéen fonctionnel par injection cellulaire, Subvention, Fondation des maladies de l'oeil (Formoeil Oculus Inc.), from 2019-04-01 to 2021-03-31
  • Rôle des mélanocytes choroïdiens dans la gestion du stress oxydatif des cellules de l’épithélium pigmentaire rétinien, Subvention, Fonds de recherche du Québec - Santé, Recherches sur la dégénérescence maculaire liée à l'âge (Programme DMLA), from 2020-04-01 to 2022-03-31
  • Utilisation de modèles cellulaires et tissulaires pour l'étude de maladies de l'oeil et du développement de nouvelles thérapies, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2019-07-01 to 2021-06-30

Recently finished projects

  • Banque de tissus oculaires pour la recherche en vision., Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2015-10-14 to 2020-03-31
  • Implication des kinines dans la DMLA neovasculaire, Subvention, Fonds de recherche du Québec - Santé, Recherches sur la dégénérescence maculaire liée à l'âge (Programme DMLA), from 2017-04-01 to 2020-05-31
Data provided by the Université Laval research projects registery