Dr. Stéphanie Proulx obtained her Ph.D. from the Université du Québec à Trois-Rivières in the Biophysics and cell biology program. She then pursued a post-doctoral internship at Laval University, where she developed an expertise in tissue engineering. Dr. Proulx is currently a researcher in the axis of regenerative medicine of the CHU de Québec-UL Research Center (St-Sacrement Hospital), an assistant Professor at the Laval University School of Medicine in the department of ophthalmology, and a researcher in the Center for research in experimental organogenesis of Laval University/LOEX. Dr. Proulx is also part of the board of directors of the Vision Health Research FRQS Network and the Cell and tissue therapy FRQS Network.

Understanding eye diseases using tissue engineering

The eye is a complex organ, and all its structures are important to have good vision. Despite advances in medicine, the causes of many eye diseases remain unclear. Using cell culture and tissue engineering, Dr. Proulx’s team developed three-dimensional models that allow to study the interactions that cells have between themselves, and with their environment. Comparing the models engineered with healthy cells with the models engineered using pathological cells, it is possible to advance our knowledge on the pathogenesis of various eye diseases. These models are also used to test different agents and for the development of new treatment strategies.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
CUO-Recherche
H2-04
Québec, Québec
Canada G1S 4L8
32 entries « 1 of 4 »

Methot SJ, Proulx S, Brunette I, Rochette PJ

Chronology of cellular events related to mitochondrial burnout leading to cell death in Fuchs endothelial corneal dystrophy.

Journal Article

Sci Rep, 10 (1), pp. 5811, 2020, ISSN: 2045-2322.

Abstract | Links:

Santerre K, Xu I, Theriault M, Proulx S

In Vitro Expansion of Corneal Endothelial Cells for Transplantation.

Journal Article

Methods Mol Biol, 2145 , pp. 17-27, 2020, ISSN: 1064-3745.

Abstract | Links:

Djigo AD, Berube J, Landreville S, Proulx S

Characterization of a tissue-engineered choroid.

Journal Article

Acta Biomater, 84 , pp. 305-316, 2019, ISSN: 1742-7061.

Abstract | Links:

Theriault M, Roy O, Brunette I, Proulx S

Physiological pressure enhances the formation of tight junctions in engineered and native corneal endothelium.

Journal Article

Exp Eye Res, 179 , pp. 102-105, 2019, ISSN: 0014-4835.

Abstract | Links:

Beaulieu Leclerc V, Roy O, Santerre K, Proulx S

TGF-β1 promotes cell barrier function upon maturation of corneal endothelial cells.

Journal Article

Sci Rep, 8 (1), pp. 4438, 2018, ISSN: 2045-2322.

Abstract | Links:

Goyer B, Theriault M, Gendron SP, Brunette I, Rochette PJ, Proulx S

Extracellular Matrix and Integrin Expression Profiles in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Model.

Journal Article

Tissue Eng Part A, 24 (7-8), pp. 607-615, 2018, ISSN: 1937-3341.

Abstract | Links:

Zhang TY, Vachon-Joannette E, Proulx S, Legare ME, Bourgault S

Delayed transient corneal edema after intravitreal injection of ocriplasmin.

Journal Article

Can J Ophthalmol, 53 (2), pp. e77-e79, 2018, ISSN: 0008-4182.

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Theriault M, Gendron SP, Brunette I, Rochette PJ, Proulx S

Function-Related Protein Expression in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Models.

Journal Article

Am J Pathol, 188 (7), pp. 1703-1712, 2018, ISSN: 0002-9440.

Abstract | Links:

Brunette I, Roberts CJ, Vidal F, Harissi-Dagher M, Lachaine J, Sheardown H, Durr GM, Proulx S, Griffith M

Alternatives to eye bank native tissue for corneal stromal replacement.

Journal Article

Prog Retin Eye Res, 59 , pp. 97-130, 2017, ISSN: 1350-9462.

Abstract | Links:

Brunette I, Proulx S

Tissue engineering of a healthy corneal endothelium for FECD patients

Book Chapter

C, Cursiefen (Ed.): Current Treatment Options for Fuchs Endothelial Dystrophy, pp. 237-255, Springer International Publishing, 2017, ISBN: 978-3-319-43019-5 (print) / 978-3-319-43021-8 (ebook).

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32 entries « 1 of 4 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en organogenèse expérimentale, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2011-05-01 to 2020-12-31
  • Fuchs endothelial corneal dystrophy and corneal transplantation: The traditional paradigm revisited, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-10-01 to 2024-09-30
  • Improving Corneal Endothelial Cell Adhesion, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2023-03-31
  • Improving Corneal Endothelial Cell Adhesion, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-07-01 to 2022-06-30
  • Influence du TFG-ß et de l’environnent physique sur la formation des jonctions intercellulaires et la transition endothélio-mésenchymateuse, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2018-04-01 to 2023-03-31
  • New Functional Polymers for Next Generation Contact Lenses - a Phase I Project, Subvention, Conseil de recherches en sciences naturelles et génie Canada, De l'idée à l'innovation (INNOV), from 2019-07-01 to 2021-06-30
  • Reformation d’un endothélium cornéen fonctionnel par injection cellulaire, Subvention, Fondation des maladies de l'oeil (Formoeil Oculus Inc.), from 2019-04-01 to 2021-03-31
  • Rôle des mélanocytes choroïdiens dans la gestion du stress oxydatif des cellules de l’épithélium pigmentaire rétinien, Subvention, Fonds de recherche du Québec - Santé, Recherches sur la dégénérescence maculaire liée à l'âge (Programme DMLA), from 2020-04-01 to 2022-03-31
  • Utilisation de modèles cellulaires et tissulaires pour l'étude de maladies de l'oeil et du développement de nouvelles thérapies, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2019-07-01 to 2021-06-30

Recently finished projects

  • Banque de tissus oculaires pour la recherche en vision., Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2015-10-14 to 2020-03-31
  • Biomarqueurs de la Dystrophie endothéliale cornéenne de Fuchs, Subvention, MITACS Inc., Bourse de formation à la recherche MITACS-UL, from 2020-06-08 to 2020-10-03
  • Implication des kinines dans la DMLA neovasculaire, Subvention, Fonds de recherche du Québec - Santé, Recherches sur la dégénérescence maculaire liée à l'âge (Programme DMLA), from 2017-04-01 to 2020-05-31
Data provided by the Université Laval research projects registery