Dr. Stéphane Gobeil is a researcher at the Centre de recherche du CHU de Québec-Laval University and an associate professor in the Department of Molecular Medicine at the Faculty of Medicine at Laval University. He completed a postdoctoral training in the Program of Gene Function and Expression at the University of Massachusetts. During his training under the supervision of Dr. Michael R. Green, he developed a highly efficient genome-wide RNA interference screening strategy that was critical to the publication of several high-impact papers.

Dr. Gobeil’s laboratory uses cellular and molecular biology as well as functional genomics to identify and determine the function of genes involved in different inflammatory pathologies such as obesity and cancer. Another important interest of his lab is molecular pharmacology, which he uses to determine the action mechanism of new small molecules with anti-inflammatory and anti-tumor potential. These two research interests make this laboratory an environment conducive to the discovery and development of therapeutic targets and biomarkers.

CHUL
2705, boulevard Laurier
R-4720
Québec, Québec
Canada G1V 4G2
CHUL
2705, boulevard Laurier
R-4772
Québec, Québec
Canada G1V 4G2

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31 entries « 2 of 4 »

Pedanou VE, Gobeil S, Tabaries S, Simone TM, Zhu LJ, Siegel PM, Green MR

The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L.

Journal Article

Elife, 5 , 2016, ISSN: 2050-084X.

Abstract | Links:

Faddaoui A, Bachvarova M, Plante M, Gregoire J, Renaud MC, Sebastianelli A, Gobeil S, Morin C, Macdonald E, Vanderhyden B, Bachvarov D

The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells.

Journal Article

Oncotarget, 7 (12), pp. 14125-42, 2016, ISSN: 1949-2553.

Abstract | Links:

Mokas S, Lariviere R, Lamalice L, Gobeil S, Cornfield DN, Agharazii M, Richard DE

Hypoxia-inducible factor-1 plays a role in phosphate-induced vascular smooth muscle cell calcification.

Journal Article

Kidney Int, 90 (3), pp. 598-609, 2016, ISSN: 0085-2538.

Abstract | Links:

Renault AL, Lesueur F, Coulombe Y, Gobeil S, Soucy P, Hamdi Y, Desjardins S, Le Calvez-Kelm F, Vallee M, Voegele C, Breast Cancer Family Registry, Hopper JL, Andrulis IL, Southey MC, John EM, Masson JY, Tavtigian SV, Simard J

ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry.

Journal Article

PLoS ONE, 11 (6), pp. e0156820, 2016.

Abstract | Links:

Wang ZQ, Faddaoui A, Bachvarova M, Plante M, Gregoire J, Renaud MC, Sebastianelli A, Guillemette C, Gobeil S, Macdonald E, Vanderhyden B, Bachvarov D

BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism.

Journal Article

Oncotarget, 6 (31), pp. 31522-43, 2015, ISSN: 1949-2553.

Abstract | Links:

Suh YE, Raulf N, Gaken J, Lawler K, Urbano TG, Bullenkamp J, Gobeil S, Huot J, Odell E, Tavassoli M

MicroRNA-196a promotes an oncogenic effect in head and neck cancer cells by suppressing annexin A1 and enhancing radioresistance.

Journal Article

Int J Cancer, 137 (5), pp. 1021-34, 2015, ISSN: 0020-7136.

Abstract | Links:

Sellars M, Huh JR, Day K, Issuree PD, Galan C, Gobeil S, Absher D, Green MR, Littman DR

Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages.

Journal Article

Nat Immunol, 16 (7), pp. 746-54, 2015, ISSN: 1529-2908.

Abstract | Links:

Vézina-Dawod S, Fortin S, Perrin M, Bordeleau LJ, Gobeil S, Biron E

Towards the development of cell permeable macrocyclic scaffolds: probing the structural requirements for enhancing cellular uptake

Book Chapter

V, Srivastava; A, Yudin; M, Lebl (Ed.): Peptides 2015 : Proceedings of the twenty-fourth American peptide symposium, June 20-25, 2015, Orlando, FL, U.S.A, pp. 127-130, San Diego, CA, American Peptide Society, 2015, ISBN: 9780983974154.

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Rodrigue A, Coulombe Y, Jacquet K, Gagne JP, Roques C, Gobeil S, Poirier G, Masson JY

The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy.

Journal Article

J Cell Sci, 126 (Pt 1), pp. 348-59, 2013, ISSN: 0021-9533.

Abstract | Links:

Wang ZQ, Keita M, Bachvarova M, Gobeil S, Morin C, Plante M, Gregoire J, Renaud MC, Sebastianelli A, Trinh XB, Bachvarov D

Inhibition of RUNX2 transcriptional activity blocks the proliferation, migration and invasion of epithelial ovarian carcinoma cells.

Journal Article

PLoS ONE, 8 (10), pp. e74384, 2013.

Abstract | Links:

31 entries « 2 of 4 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Validation of Highly Potent Substituted Phenyl Alkylureas as Antipsoriatic Agents, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2021-03-31

Recently finished projects

  • Les phénylimidazolidones, de nouvelles molécules pour le traitement personnalisé des cancers du sein hormono- et chimiorésistants: du laboratoire vers la clinique., Subvention, Fondation de l'Université Laval, from 2015-10-01 to 2019-07-30
  • Substituted phenyl alkylureas as new potent antipsoriatic drugs: Mechanism of action and structure-activity relationships., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2020-06-30
Data provided by the Université Laval research projects registery