Dr. Stéphane Gobeil is a researcher at the Centre de recherche du CHU de Québec-Laval University and an associate professor in the Department of Molecular Medicine at the Faculty of Medicine at Laval University. He completed a postdoctoral training in the Program of Gene Function and Expression at the University of Massachusetts. During his training under the supervision of Dr. Michael R. Green, he developed a highly efficient genome-wide RNA interference screening strategy that was critical to the publication of several high-impact papers.
Dr. Gobeil’s laboratory uses cellular and molecular biology as well as functional genomics to identify and determine the function of genes involved in different inflammatory pathologies such as obesity and cancer. Another important interest of his lab is molecular pharmacology, which he uses to determine the action mechanism of new small molecules with anti-inflammatory and anti-tumor potential. These two research interests make this laboratory an environment conducive to the discovery and development of therapeutic targets and biomarkers.
2705, boulevard Laurier
R-4720
Québec, Québec
Canada G1V 4G2
2705, boulevard Laurier
R-4772
Québec, Québec
Canada G1V 4G2
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- Boutin, JoëlDoctoral studentCHUL+1 418-525-4444, extension 42296joel.boutin.1@ulaval.cajoel.boutin@crchudequebec.ulaval.ca
2705, boulevard Laurier
R-4736
Québec, Québec
Canada G1V 4G2 - Carpentier, AntoineMaster student+1 418-525-4444, extension 42296antoine.carpentier@crchudequebec.ulaval.ca
- Fazazi, Mohamed RedaInternmohamed-reda.fazazi@crchudequebec.ulaval.ca
- Perreault, MartinDoctoral studentCHUL+1 418-525-4444, extension 46014 / 42296+1 418-654-2298martin.perreault.2@ulaval.caMartin.Perreault@crchudequebec.ulaval.ca
2705, boulevard Laurier
R-4701.1
Québec, Québec
Canada G1V 4G2
Evaluation of the time-dependent antiproliferative activity and liver microsome stability of 3 phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as promising CYP1A1-dependent antimicrotubule prodrugs.
Journal ArticleJ Pharm Pharmacol, 2019, ISSN: 0022-3573.
The polypeptide GALNT6 Displays Redundant Functions upon Suppression of its Closest Homolog GALNT3 in Mediating Aberrant O-Glycosylation, Associated with Ovarian Cancer Progression.
Journal ArticleInt J Mol Sci, 20 (9), 2019.
Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133.
Journal ArticlePharmacol Res, 128 , pp. 52-60, 2018, ISSN: 1043-6618.
Lung cancer susceptibility genetic variants modulate HOXB2 expression in the lung.
Journal ArticleInt J Dev Biol, 62 (11-12), pp. 857-864, 2018, ISSN: 0214-6282.
Hic-5 regulates epithelial to mesenchymal transition in ovarian cancer cells in a TGFβ1-independent manner.
Journal ArticleOncotarget, 8 (47), pp. 82506-82530, 2017, ISSN: 1949-2553.
Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells.
Journal ArticleJ Med Chem, 60 (12), pp. 4963-4982, 2017, ISSN: 0022-2623.
Suppression of the grainyhead transcription factor 2 gene (GRHL2) inhibits the proliferation, migration, invasion and mediates cell cycle arrest of ovarian cancer cells.
Journal ArticleCell Cycle, 16 (7), pp. 693-706, 2017, ISSN: 1538-4101.
Amplification of Adipogenic Commitment by VSTM2A.
Journal ArticleCell Rep, 18 (1), pp. 93-106, 2017.
FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells.
Journal ArticleSci Rep, 6 , pp. 34962, 2016, ISSN: 2045-2322.
Three-Dimensional Culture Assay to Explore Cancer Cell Invasiveness and Satellite Tumor Formation.
Journal ArticleJ Vis Exp, (114), 2016.
Active projects
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Substituted phenyl alkylureas as new potent antipsoriatic drugs: Mechanism of action and structure-activity relationships., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2020-06-30
- Validation of Highly Potent Substituted Phenyl Alkylureas as Antipsoriatic Agents, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2021-03-31
Recently finished projects
- Centre de recherche en endocrinologie, métabolisme et inflammation, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2018-04-30
- Les phénylimidazolidones, de nouvelles molécules pour le traitement personnalisé des cancers du sein hormono- et chimiorésistants: du laboratoire vers la clinique., Subvention, Fondation de l'Université Laval, from 2015-10-01 to 2019-07-30