In addition to being a regular researcher at the CHU Research Center of Québec-Laval University (Regenerative Medicine Axis) and Assistant Professor in the Department of Ophthalmology and Otolaryngology-Head and Neck Surgery at the Faculty of Medicine of Laval University, Dr. Solange Landreville is a regular researcher at the Center for Research in Experimental Organogenesis at Laval University / LOEX. Her work focuses on the development of treatment for the metastatic stage of ocular melanoma, and the improvement of cell culture and tissue engineering models in ophthalmology.
Dr. Landreville is a Junior 1 Research Fellow with the Fonds de recherche du Québec – Santé (FRQS) and was the recipient of the Bernard-Belleau Award from the Association Francophone pour le savoir (ACFAS) in 2005.
Develop a treatment for metastatic uveal melanoma
Uveal melanoma is the most common primary intraocular tumor in adults, and the second most common type of melanoma after the skin. It is a sporadic cancer, and familial cases are very rare. It is therefore difficult to prevent or justify large-scale screening tests. Metastases to the liver occur in half of the cases, despite the success of the eye’s treatment. Translational research on uveal melanoma has progressed rapidly in the last decade, with the development of prognostic genetic tools, but the main obstacle to improving patient survival remains the notorious resistance of this cancer to treatment. We must therefore focus our efforts on the characterization of the tumor / metastatic microenvironment (hypoxia, stromal cells, extracellular matrix, epigenetic). This research is important because it will provide crucial information on the molecular mechanisms of resistance to cancer and stromal cell treatment. Any innovative treatment that will stop the growth of uveal melanoma cells in the liver could turn the deadly metastatic stage into a chronic disease, impacting the overall patient survival rate.
Study of oxygen’s effects on the physiology of different eye cell types
Cell culture is essential to better understand the physiology of normal and pathological cells, as well as tissue reconstruction. It is traditionally carried out in incubators with 21% oxygen (atmospheric rate), which does not represent physiological conditions. In fact, oxygen is transported by the blood and delivered to the tissues at rates lower than 14%. This physiological oxygen level varies from one tissue to another, as well as within the tissue depending on the vascularization and metabolic activity. There is also a significant decrease in oxygen supply (hypoxia) in tumors. Several ocular pathologies affecting Canadians involve oxygen deficiency in their progression, such as uveal melanoma (ocular cancer) and diabetic retinopathy (complication of diabetes). Transfer of results obtained through research to the clinic depends strongly on their physiological validity, and thus on the maintenance of biological functions in the cells in culture, which are close to those found in the tissues of origin. It is therefore essential to modulate oxygen levels for the improvement of cell culture and tissue engineering models in ophthalmology.
1050, chemin Sainte-Foy
CUO-Recherche, Bureau H2-02
Canada G1S 4L8
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1050 Chemin Sainte-Foy
Canada G1S 4L8
- Gros-Louis, PhilippeMaster email@example.com
- Marcoux, SylvieEmployeeSylvie.Marcoux@crchudequebec.ulaval.ca
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Effects of Long-term Serial Passaging on the Characteristics and Properties of Cell Lines Derived From Uveal Melanoma Primary Tumors.Journal Article
Invest Ophthalmol Vis Sci, 57 (13), pp. 5288-5301, 2016, ISSN: 0146-0404.
Contribution of Sp1 to Telomerase Expression and Activity in Skin Keratinocytes Cultured With a Feeder Layer.Journal Article
J Cell Physiol, 230 (2), pp. 308-17, 2015, ISSN: 0021-9541.
Mechanisms of resistance to imatinib mesylate in KIT-positive metastatic uveal melanoma.Journal Article
Clin Exp Metastasis, 31 (5), pp. 553-64, 2014, ISSN: 0262-0898.
Increased HIF-1α expression correlates with cell proliferation and vascular markers CD31 and VEGF-A in uveal melanoma.Journal Article
Invest Ophthalmol Vis Sci, 55 (3), pp. 1277-83, 2014, ISSN: 0146-0404.
Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction.Journal Article
J Clin Invest, 123 (12), pp. 5152-64, 2013, ISSN: 0021-9738.
Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.Journal Article
Clin Cancer Res, 18 (2), pp. 408-16, 2012, ISSN: 1078-0432.
Repression of genes involved in melanocyte differentiation in uveal melanoma.Journal Article
Mol Vis, 18 , pp. 1813-22, 2012.
Suppression of α5 gene expression is closely related to the tumorigenic properties of uveal melanoma cell lines.Journal Article
Pigment Cell Melanoma Res, 24 (4), pp. 643-55, 2011, ISSN: 1755-1471.
ABCB1 identifies a subpopulation of uveal melanoma cells with high metastatic propensity.Journal Article
Pigment Cell Melanoma Res, 24 (3), pp. 430-7, 2011, ISSN: 1755-1471.
Identification of differentially expressed genes in uveal melanoma using suppressive subtractive hybridization.Journal Article
Mol Vis, 17 , pp. 1324-33, 2011.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Centre de recherche en organogenèse expérimentale, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2011-05-01 to 2020-09-22
- Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
- Generation of a humanized immunodeficient mouse model with both human immune system and hepatic stellate cells to study the degree of immune cell infiltration in metastatic uveal melanoma lesions, Subvention, Fonds de recherche du Québec - Santé, Programme Réseautage national et international, from 2018-04-01 to 2020-09-30
- Rôle des mélanocytes choroïdiens dans la gestion du stress oxydatif des cellules de l’épithélium pigmentaire rétinien, Subvention, Fonds de recherche du Québec - Santé, Recherches sur la dégénérescence maculaire liée à l'âge (Programme DMLA), from 2020-04-01 to 2022-03-31
- Roles of melanocytes in choroid homeostasis, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2020-04-01 to 2025-03-31
Recently finished projects
- Banque québécoise pour la recherche sur le mélanome uvéal, Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2017-04-01 to 2020-03-31
- Banque québécoise pour la recherche sur le mélanome uvéal, Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2014-12-09 to 2020-03-31
- Extracellular vesicles secreted by uveal melanoma cells: role and clinical value, Subvention, Fonds de recherche du Québec - Santé, Programme Réseautage national et international, from 2018-04-01 to 2020-03-31
- Rôle du microenvironnement tumoral et métastatique dans la progression du mélanome uvéal., Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2015-07-01 to 2019-06-30