Regular scientist at the CHU de Québec-Université Laval Research Center and full professor in the Department of Molecular Medicine at the Laval University Medical School. He is a renowned Canadian scientist who has contributed to the advancement and acceptance of major new scientific concepts. This work has demonstrated that the CNS is a highly immunologically active organ, with complex immune responses, mostly based on innate immune processes. Such responses implicate a continuum of heterogeneous cell types, both inside the CNS, in the periphery, and at their interface, the blood brain barrier (BBB). The goal here is to manipulate such a system to prevent and cure brain diseases. Canadian Research Chair in Neuroimmunology, Twice named Quebec laureate, Radio Canada and Le Soleil (2007 et 2013). Over 21 000 citations and H factor 81.

The immune system at the rescue of brain diseases

The inflammatory response in neurodegenerative diseases has often been linked to progressive neuronal damage. However, mounting evidence now suggests that CNS-resident microglia and circulating monocytes that differentiate into macrophages upon infiltrating the cerebral tissue may exert more beneficial effects on neurons than previously thought. The innate immune system in the brain exhibits a dual nature, as best exemplified by multiple sclerosis (MS) and Alzheimer’s disease (AD), which are often treated as being brain diseases with similar immune etiologies. In reality, they are rather “Yin and Yang” in that regard.

Thus, the role of the inflammatory response seems highly divergent between MS and AD. On the one hand, the marked and sustained activation of proinflammatory monocytic cells promotes demyelination and axonal loss in MS, but on the other hand, it is the anti-inflammatory (or inactivated) phenotype of these cells that allows CNS amyloid accumulation, neuronal dysfunction and memory decline in AD. This research program is focused on thoroughly unraveling the mechanistic details of the role of the innate immune system in the CNS, and how it can be tackled to exert neuroprotective actions.

Vision: A multidisciplinary approach, integrating innovative discoveries and technologies, to validate the concept of the neuroprotective properties of the innate immune system, to improve brain disease diagnosis and treatment.

Goals: Our main goals are to provide new biomarkers for diagnosis and to obtain proofs-of-concept that will lead to new treatments of brain diseases based on the neuroprotective functions of innate immunity.

Objectives: 1) To decipher the molecular and cellular mechanisms involved in the intimate control of different compartments of the brain innate immune system. 2) To identify new biomarkers from the analysis of subsets of circulating monocytes in preclinical models of MS and AD. 3) To use and develop complementary models and methods to understand how myeloid cells can be harnessed in exerting neuroprotective actions. 4) To validate new biomarkers and concepts of the beneficial role of the innate immune system in humans.

CHUL
2705, boulevard Laurier
T-2-50
Québec, Québec
Canada G1V 4G2
CHUL
2705, boulevard Laurier
T-4-50
Québec, Québec
Canada G1V 4G2
239 entries « 1 of 24 »

Uyar O, Laflamme N, Piret J, Venable MC, Carbonneau J, Zarrouk K, Rivest S, Boivin G

An Early Microglial Response Is Needed To Efficiently Control Herpes Simplex Virus Encephalitis.

Journal Article

J Virol, 94 (23), 2020, ISSN: 0022-538X.

Abstract | Links:

Fani Maleki A, Cisbani G, Plante MM, Prefontaine P, Laflamme N, Gosselin J, Rivest S

Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer's disease.

Journal Article

J Neuroinflammation, 17 (1), pp. 218, 2020.

Abstract | Links:

Auger JP, Rivest S, Benoit-Biancamano MO, Segura M, Gottschalk M

Inflammatory Monocytes and Neutrophils Regulate Streptococcus suis-Induced Systemic Inflammation and Disease but Are Not Critical for the Development of Central Nervous System Disease in a Mouse Model of Infection.

Journal Article

Infect Immun, 88 (3), 2020, ISSN: 0019-9567.

Abstract | Links:

Picher-Martel V, Labrie Y, Rivest S, Lace B, Chrestian N

Whole-exome sequencing identifies homozygous mutation in TTI2 in a child with primary microcephaly: a case report.

Journal Article

BMC Neurol, 20 (1), pp. 58, 2020, ISSN: 1471-2377.

Abstract | Links:

Pons V, Laflamme N, Prefontaine P, Rivest S

Role of Macrophage Colony-Stimulating Factor Receptor on the Proliferation and Survival of Microglia Following Systemic Nerve and Cuprizone-Induced Injuries.

Journal Article

Front Immunol, 11 , pp. 47, 2020, ISSN: 1664-3224.

Abstract | Links:

Anwar S, Rivest S

Alzheimer's disease: microglia targets and their modulation to promote amyloid phagocytosis and mitigate neuroinflammation.

Journal Article

Expert Opin Ther Targets, 24 (4), pp. 331-344, 2020, ISSN: 1472-8222.

Abstract | Links:

Pons V, Rivest S

Beneficial Roles of Microglia and Growth Factors in MS, a Brief Review.

Journal Article

Front Cell Neurosci, 14 , pp. 284, 2020.

Abstract | Links:

El Hajj H, Savage JC, Bisht K, Parent M, Vallieres L, Rivest S, Tremblay ME

Ultrastructural evidence of microglial heterogeneity in Alzheimer's disease amyloid pathology.

Journal Article

J Neuroinflammation, 16 (1), pp. 87, 2019.

Abstract | Links:

Fani Maleki A, Rivest S

Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer's Disease and Multiple Sclerosis.

Journal Article

Front Cell Neurosci, 13 , pp. 355, 2019.

Abstract | Links:

Gosselin D, Rivest S

Getting Too Old Too Quickly for Their Job: Senescent Glial Cells Promote Neurodegeneration.

Journal Article

Neuron, 100 (4), pp. 777-779, 2018, ISSN: 0896-6273.

Abstract | Links:

239 entries « 1 of 24 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2023-05-01
  • Centres de recherche du CHU de Québec - UL, Subvention, Fonds de recherche du Québec - Santé, Centres de recherche situés dans des centres hospitaliers universitaires (CHU), instituts universitaires (IU) et centres affiliés universitaires (CAU) - Subvention régulière, from 2014-04-01 to 2025-03-31
  • Chaire de recherche du Canada en neuroimmunologie, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Chaires de recherche du Canada - Fonctionnement, from 2016-07-01 to 2023-06-30
  • Soutenir les établissements dans l'augmentation de leur capacité en recherche - agir sur la phase de démarrage des projets , Partenariat, Ministère de l'Économie et de l'Innovation, Programme de soutien aux organismes de recherche et d’innovation (PSO) - Recherche-innovation - Volet 2a, from 2019-04-01 to 2021-03-31
  • Therapeutic properties of innate immune cells and system for brain diseases., Subvention, Instituts de recherche en santé du Canada, Subventions Fondation, from 2015-07-01 to 2022-06-30

Recently finished projects

  • Aménagement du secteur préclinique du centre de recherche , Partenariat, Ministère de l'Économie et de l'Innovation, Programme de soutien aux organismes de recherche et d'innovation (PSO) - Volet 4: Soutien au financement d'infrastructures de recherche et d'innovation, from 2018-12-01 to 2020-03-31
  • Appui au développement de la capacité en études cliniques précoces, Partenariat, Ministère de l'Économie, de la Science et de l'Innovation, Programme de soutien à la recherche (PSR) Soutien à des organismes ou des projets de recherche volet 1, from 2018-04-01 to 2020-03-31
  • Développement de marqueurs génétiques de maladies rares., Subvention, Fondation du CHU de Québec, from 2016-02-11 to 2020-02-10
  • Neurophotonics Initiative, phase II, Partenariat, Fondation Canadienne pour l'innovation (La), Fonds d'innovation (FI), from 2015-10-01 to 2020-09-30
Data provided by the Université Laval research projects registery