Dr. Hébert was born in Montréal in 1974. He studied biotechnology, and obtained his Ph.D. in Cellular and Molecular Biology at Laval University in 2003. He then completed a postdoctoral fellowship in human genetics at the Katholieke Universiteit Leuven in Belgium. In 2009, he was recruited as Assistant Professor at Laval University. Dr. Hébert is currently an Associate Professor in the Department of Psychiatry and Neuroscience at Laval University. He is also a researcher (group leader) in the Neuroscience Unit of the Research Center of the CHU de Québec – Laval University.

Dr. Hébert’s work focuses on the biological and molecular mechanisms that cause neuronal death and dementia. Specifically, his research team studies the role of micro-RNAs in the development, diagnosis, and treatment of neurodegenerative diseases such as Alzheimer’s disease, frontotemporal dementia, and Huntington’s disease. Micro-RNAs are small molecules in the body that are similar to DNA and regulate the level of proteins. Dr. Hébert’s pioneering research has shown that many micro-RNAs are deregulated in patients with Alzheimer’s disease, and other types of dementia. Curiously, a number of these molecules can reproduce the pathological and clinical symptoms of dementia in biological models on their own, such as cultured neurons and mice. Dr. Hébert also uses the postmortem human brain as an indispensable tool for his research.

Recently, his work on a potential treatment for Alzheimer’s disease was presented by Le Soleil, the FM93 radio station, and The Alzheimer’s Society of Canada’s Website.

Dr. Hébert has received various awards, including the Alzheimer’s Society of Saskatchewan’s Young Investigator Grant (2010) and the FRQS Junior Research Scholar Career Award (2011, 2014). He has been a spokesperson for the Alzheimer’s Society of Canada (2011). In addition to his commitment to teaching, he regularly participates in various evaluation committees and conferences. Finally, he helps organize events and promote basic Canadian research on Alzheimer’s disease, and related dementias.

CHUL
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Québec, Québec
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67 entries « 2 of 7 »

Liu D, Tang H, Li XY, Deng MF, Wei N, Wang X, Zhou YF, Wang DQ, Fu P, Wang JZ, Hebert SS, Chen JG, Lu Y, Zhu LQ

Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease.

Journal Article

Mol Ther, 25 (3), pp. 752-764, 2017, ISSN: 1525-0016.

Abstract | Links:

Olde Loohuis NF, Nadif Kasri N, Glennon JC, van Bokhoven H, Hebert SS, Kaplan BB, Martens GJ, Aschrafi A

The schizophrenia risk gene MIR137 acts as a hippocampal gene network node orchestrating the expression of genes relevant to nervous system development and function.

Journal Article

Prog Neuropsychopharmacol Biol Psychiatry, 73 , pp. 109-118, 2017, ISSN: 0278-5846.

Abstract | Links:

Hernandez-Rapp J, Rainone S, Hebert SS

MicroRNAs underlying memory deficits in neurodegenerative disorders.

Journal Article

Prog Neuropsychopharmacol Biol Psychiatry, 73 , pp. 79-86, 2017, ISSN: 0278-5846.

Abstract | Links:

Petry FR, Nicholls SB, Hebert SS, Planel E

A Simple Method to Avoid Nonspecific Signal When Using Monoclonal Anti-Tau Antibodies in Western Blotting of Mouse Brain Proteins.

Journal Article

Methods Mol Biol, 1523 , pp. 263-272, 2017, ISSN: 1064-3745.

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Hernandez-Rapp J, Rainone S, Goupil C, Dorval V, Smith PY, Saint-Pierre M, Vallee M, Planel E, Droit A, Calon F, Cicchetti F, Hebert SS

microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice.

Journal Article

Sci Rep, 6 , pp. 30953, 2016, ISSN: 2045-2322.

Abstract | Links:

El Khoury NB, Gratuze M, Petry F, Papon MA, Julien C, Marcouiller F, Morin F, Nicholls SB, Calon F, Hebert SS, Marette A, Planel E

Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.

Journal Article

Neurobiol Dis, 88 , pp. 55-65, 2016, ISSN: 0969-9961.

Abstract | Links:

Nicolas G, Wallon D, Goupil C, Richard AC, Pottier C, Dorval V, Sarov-Riviere M, Riant F, Herve D, Amouyel P, Guerchet M, Ndamba-Bandzouzi B, Mbelesso P, Dartigues JF, Lambert JC, Preux PM, Frebourg T, Campion D, Hannequin D, Tournier-Lasserve E, Hebert SS, Rovelet-Lecrux A

Mutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy.

Journal Article

Eur J Hum Genet, 24 (1), pp. 92-8, 2016, ISSN: 1018-4813.

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Gratuze M, Julien J, Morin F, Calon F, Hebert SS, Marette A, Planel E

High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology.

Journal Article

Neurobiol Aging, 47 , pp. 71-73, 2016, ISSN: 0197-4580.

Abstract | Links:

Smith PY, Hernandez-Rapp J, Jolivette F, Lecours C, Bisht K, Goupil C, Dorval V, Parsi S, Morin F, Planel E, Bennett DA, Fernandez-Gomez FJ, Sergeant N, Buee L, Tremblay ME, Calon F, Hebert SS

miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo.

Journal Article

Hum Mol Genet, 24 (23), pp. 6721-35, 2015, ISSN: 0964-6906.

Abstract | Links:

Parsi S, Smith PY, Goupil C, Dorval V, Hebert SS

Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease.

Journal Article

Mol Ther Nucleic Acids, 4 , pp. e256, 2015.

Abstract | Links:

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