Dr. Samer Hussein is a researcher at the CHU Research Centre of Quebec – Laval University, and is part of the St-Patrick group of research in fundamental oncology. He is also Assistant Professor in the Department of Molecular Biology, Medical Biochemistry and Pathology of the Faculty of Medicine, Laval University.

His research aims to understand the molecular mechanisms that establish and regulate pluripotent cell states, particularly the role of long non-coding RNAs in gene networks, as well as the transcriptional events responsible for cancer initiation and progression.

Defining gene networks and their interactions that govern pluripotent states

Pluripotency is defined as the ability of a cell to generate all the cell types found in an organism. The three transcription factors Oct4, Sox2, and Nanog represent the central pillars of the gene regulatory network associated with the maintenance of a pluripotent state. Through cellular models of pluripotency and reprogramming, and the use of high-throughput technologies (proteomics, RNA-seq and ChIP-seq), this project aims to understand how interactions between transcription factors of pluripotency and chromatin regulators determine cell fate and cell transition to specific lineages in embryonic development, as well as cancer development.

Defining the role of certain long non-coding RNAs in cell identity

Long non-coding RNAs (lncRNA) constitute an entire class of RNA, characterized by the fact that they do not encode any known protein and that they are composed of at least 200 base pairs. LncRNAs are implicated in gene regulation and maintenance of cellular identity, but their mechanism of action involved in the establishment of pluripotency remains unknown. The objective of this project is to understand the role of lncRNAs in the regulation of pluripotent states and the reprogramming of embryonic stem cells.

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Lee DS, Shin JY, Tonge PD, Puri MC, Lee S, Park H, Lee WC, Hussein SM, Bleazard T, Yun JY, Kim J, Li M, Cloonan N, Wood D, Clancy JL, Mosbergen R, Yi JH, Yang KS, Kim H, Rhee H, Wells CA, Preiss T, Grimmond SM, Rogers IM, Nagy A, Seo JS

An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator.

Journal Article

Nat Commun, 5 , pp. 5619, 2014, ISSN: 2041-1723.

Abstract | Links:

Michael IP, Westenskow PD, Hacibekiroglu S, Greenwald AC, Ballios BG, Kurihara T, Li Z, Warren CM, Zhang P, Aguilar E, Donaldson L, Marchetti V, Baba T, Hussein SM, Sung HK, Iruela-Arispe ML, Rini JM, van der Kooy D, Friedlander M, Nagy A

Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye.

Journal Article

EMBO Mol Med, 6 (5), pp. 604-23, 2014, ISSN: 1757-4676.

Abstract | Links:

Laurila K, Autio R, Kong L, Narva E, Hussein S, Otonkoski T, Lahesmaa R, Lahdesmaki H

Integrative genomics and transcriptomics analysis of human embryonic and induced pluripotent stem cells.

Journal Article

BioData Min, 7 (1), pp. 32, 2014.

Abstract | Links:

Hussein SM, Elbaz J, Nagy AA

Genome damage in induced pluripotent stem cells: assessing the mechanisms and their consequences.

Journal Article

Bioessays, 35 (3), pp. 152-62, 2013, ISSN: 0265-9247.

Abstract | Links:

Carlsson E, Krohn K, Ovaska K, Lindberg P, Hayry V, Maliniemi P, Lintulahti A, Korja M, Kivisaari R, Hussein S, Sarna S, Niiranen K, Hautaniemi S, Haapasalo H, Ranki A

Neuron navigator 3 alterations in nervous system tumors associate with tumor malignancy grade and prognosis.

Journal Article

Genes Chromosomes Cancer, 52 (2), pp. 191-201, 2013, ISSN: 1045-2257.

Abstract | Links:

Hussein SM, Nagy AA

Progress made in the reprogramming field: new factors, new strategies and a new outlook.

Journal Article

Curr Opin Genet Dev, 22 (5), pp. 435-43, 2012, ISSN: 0959-437X.

Abstract | Links:

Ji J, Ng SH, Sharma V, Neculai D, Hussein S, Sam M, Trinh Q, Church GM, McPherson JD, Nagy A, Batada NN

Elevated coding mutation rate during the reprogramming of human somatic cells into induced pluripotent stem cells.

Journal Article

Stem Cells, 30 (3), pp. 435-40, 2012, ISSN: 1066-5099.

Abstract | Links:

Bisson N, Ruston J, Jeansson M, Vanderlaan R, Hardy WR, Du J, Hussein SM, Coward RJ, Quaggin SE, Pawson T

The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier.

Journal Article

PLoS ONE, 7 (11), pp. e50996, 2012.

Abstract | Links:

Hussein SM, Nagy K, Nagy A

Human induced pluripotent stem cells: the past, present, and future.

Journal Article

Clin Pharmacol Ther, 89 (5), pp. 741-5, 2011, ISSN: 0009-9236.

| Links:

Hussein SM, Batada NN, Vuoristo S, Ching RW, Autio R, Narva E, Ng S, Sourour M, Hamalainen R, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M, Brustle O, Bazett-Jones DP, Alitalo K, Lahesmaa R, Nagy A, Otonkoski T

Copy number variation and selection during reprogramming to pluripotency.

Journal Article

Nature, 471 (7336), pp. 58-62, 2011, ISSN: 0028-0836.

Abstract | Links:

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