Dr. De Serres received his MD from University of Montreal and FRCPC in Internal Medicine and Nephrology following residency at Laval University in Canada. He then completed a 3-year Research Fellowship in transplant immunology at the Brigham and Women’s Hospital and received a Master of Epidemiology from Harvard School of Public Health. He is currently Associate Professor of Medicine at Laval University and Clinician-Scientist Junior II FRQS scholar.

At the national level, he has served as Chair of the 2018 Canadian Society of Transplantation Scientific Committee, in charge of organizing the Canadian Transplant Summit. At the international level, he has been elected as Executive Member of American Society of Transplantation Transplant Diagnostic Committee for a 2-year term, from 2016 to 2018. He also served as a member of the AST Transplantation and Immunology Research Network Scientific Committee from 2015 to 2018.

His research program focuses on cell-based assays to identify over-immunosuppression and on the mechanisms of antibody-mediated rejection. Since 2011, he has received continuous funding from different agencies including Kidney Foundation of Canada, CIHR, CFI and FRQS. His lab is currently funded by a CIHR Project Scheme grant and he is co-investigator and collaborator on several multicenter projects, including the CIHR-funded TMCT-04 trial and the Genome Canada-funded Can PREVENT AMR study.

L'Hôtel-Dieu de Québec
9, rue McMahon
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Québec, Québec
Canada G1R 2J6
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McRae M, Bouchard-Boivin F, Beland S, Noel R, Cote I, Lapointe I, Lesage J, Latulippe E, Riopel J, Santoriello D, Husain SA, Desy O, Houde I, Batal I, De Serres SA

Impact of the Current Versus the Previous Diagnostic Threshold on the Outcome of Patients With Borderline Changes Suspicious for T Cell-mediated Rejection Diagnosed on Indication Biopsies.

Journal Article

Transplantation, 102 (12), pp. 2120-2125, 2018, ISSN: 0041-1337.

Abstract | Links:

Santoriello D, Husain SA, De Serres SA, Bomback AS, Crew RJ, Vasilescu ER, Serban G, Campenot ES, Kiryluk K, Mohan S, Hawkins GA, Hicks PJ, Cohen DJ, Radhakrishnan J, Stokes MB, Markowitz GS, Freedman BI, D'Agati VD, Batal I

Donor APOL1 high-risk genotypes are associated with increased risk and inferior prognosis of de novo collapsing glomerulopathy in renal allografts.

Journal Article

Kidney Int, 94 (6), pp. 1189-1198, 2018, ISSN: 0085-2538.

Abstract | Links:

Sidibe A, Fortier C, Desjardins MP, Zomahoun HTV, Boutin A, Mac-Way F, De Serres S, Agharazii M

Reduction of Arterial Stiffness After Kidney Transplantation: A Systematic Review and Meta-Analysis.

Journal Article

J Am Heart Assoc, 6 (12), 2017, ISSN: 2047-9980.

Abstract | Links:

Jardine MJ, Mahaffey KW, Neal B, Agarwal R, Bakris GL, Brenner BM, Bull S, Cannon CP, Charytan DM, de Zeeuw D, Edwards R, Greene T, Heerspink HJL, Levin A, Pollock C, Wheeler DC, Xie J, Zhang H, Zinman B, Desai M, Perkovic V, CREDENCE study investigators

The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics.

Journal Article

Am J Nephrol, 46 (6), pp. 462-472, 2017, ISSN: 0250-8095.

Abstract | Links:

Beland MA, Lapointe I, Noel R, Cote I, Wagner E, Riopel J, Latulippe E, Desy O, Beland S, Magee CN, Houde I, De Serres SA

Higher calcineurin inhibitor levels predict better kidney graft survival in patients with de novo donor-specific anti-HLA antibodies: a cohort study.

Journal Article

Transpl Int, 30 (5), pp. 502-509, 2017, ISSN: 0934-0874.

Abstract | Links:

Desjardins MP, Thorin-Trescases N, Sidibe A, Fortier C, De Serres SA, Lariviere R, Thorin E, Agharazii M

Levels of Angiopoietin-Like-2 Are Positively Associated With Aortic Stiffness and Mortality After Kidney Transplantation.

Journal Article

Am J Hypertens, 30 (4), pp. 409-416, 2017, ISSN: 0895-7061.

Abstract | Links:

Fortier C, Sidibe A, Desjardins MP, Marquis K, De Serres SA, Mac-Way F, Agharazii M

Aortic-Brachial Pulse Wave Velocity Ratio: A Blood Pressure-Independent Index of Vascular Aging.

Journal Article

Hypertension, 69 (1), pp. 96-101, 2017, ISSN: 0194-911X.

Abstract | Links:

Beland S, Vallin P, Desy O, Levesque E, De Serres SA

Effects of alloantibodies to human leukocyte antigen on endothelial expression and serum levels of thrombomodulin.

Journal Article

J Thromb Haemost, 15 (5), pp. 1020-1031, 2017, ISSN: 1538-7933.

Abstract | Links:

Iliuta IA, Lachance P, Ghannoum M, Begin Y, Mac-Way F, Desmeules S, De Serres SA, Julien AS, Douville P, Agharazii M

Prediction and validation of the duration of hemodialysis sessions for the treatment of acute ethylene glycol poisoning.

Journal Article

Kidney Int, 92 (2), pp. 453-460, 2017, ISSN: 0085-2538.

Abstract | Links:

Vallin P, Desy O, Beland S, Wagner E, De Serres SA

Clinical relevance of circulating antibodies and B lymphocyte markers in allograft rejection.

Journal Article

Clin Biochem, 49 (4-5), pp. 385-93, 2016, ISSN: 0009-9120.

Abstract | Links:

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Active projects

  • A randomized controlled effectiveness trial of urine CXCL10 chemokine monitoring post-renal transplant, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2016-07-01 to 2021-06-30
  • Aldosterone antagonism and enhanced Clearance for Health Improvement EValuation in End-stage renal disease (ACHIEVE) Trial, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2016-07-01 to 2022-06-30
  • Arterial stiffness gradient as a new index of vascular aging: impact of blood pressure lowering medication, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-10-01 to 2024-09-30
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Development and validation of a cell-based assay to identify over-immunosuppression in kidney transplant recipients, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-10-01 to 2023-09-30
  • Development and validation of a cellular assay to identify over-immunosupression in kidney transplants recipients, Subvention, Fondation canadienne du rein, Subvention de soutien à la recherche biomédicale, from 2019-07-01 to 2021-06-30
  • Mieux comprendre les mécanismes immunologiques du rejet chronique chez le greffé rénal afin d'améliorer le diagnostic et la prise en charge thérapeutique, Subvention, Fonds de recherche du Québec - Santé, Chercheurs-boursiers cliniciens - Juniors 1 et 2, Seniors, from 2018-07-01 to 2020-06-30
  • Precision Medicine CanPREVENT AMR: Applying Precision Medicine Technologies in Canada to Prevent Antibody Mediated Rejection and Premature Kidney Transplant Loss, Subvention, Génome Canada, Projets de recherche appliquée à grande échelle, from 2018-04-01 to 2022-03-31
  • Rôle des cellules dendritiques dans l'immunologie de la transplantation., Subvention, Fondation de l'Université Laval, from 2015-01-01 to 2024-05-31

Recently finished projects

  • (FRSQ 78509)Perfectionnement de l'outil de surveillance immunitaire chez les patients greffés rénaux(validation des observations), Subvention, Fondation du CHU de Québec, from 2017-06-12 to 2018-06-11
  • Centre de recherche en endocrinologie, métabolisme et inflammation, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2018-04-30
  • Évaluation du rôle de l’inflammation et des monocytes dans le développement du dommage de l’allogreffon en transplantation, Subvention, Fondation de l'Université Laval, from 2016-04-01 to 2018-04-30
  • The Role of Dendritic Cells and Follicular Helper T cells in Antibody-Mediated Rejection of the Kidney Graft, Subvention, Fondation canadienne du rein, Subvention de soutien à la recherche biomédicale, from 2017-07-01 to 2019-06-30
Data provided by the Université Laval research projects registery